Cachexia - ihe ọ bụ? Cachexia na cancer

Cachexia - ihe ọ bụ? Cachexia, ndị ọzọ okwu, depletion nke ahu - a mgbagwoju usoro e ji a ịrịba ọnwụ nke ahu aro na izugbe adịghị ike nakwa dị ka mgbanwe n'uche. Nke a n'ụzọ dị ịrịba ama depleted abụba na carbohydrate mee, belata protein njikọ, mgbe na-amụba ya catabolism (mmebi). Cachexia nwekwara ike ime na oncological ọrịa.

Primary na sekọndrị gwụrụ

Abụọ iche nke cachexia ọrịa - isi na sekọndrị. Primary depletion a na-akpọ ndị pituitary, na nke abụọ - symptomatic.

● Primary ma ọ bụ exogenous cachexia emee n'ihi erighị ihe na-edozi ahụ, nakwa dị ka a N'ihi ya nke ndị na-esonụ na-anaghị ekwe: ọrịa ụbụrụ trauma, akpụ ma ọ bụ systemic lesion pituitary, autoimmune hypophysitis, inwe nchekasị, hemorrhage (na-agba ọbara n'oge thinning arịa), anorexia, embolism ( ingress nke ndị mba ọzọ ahụ na ọbara ugbu a, na-eme vaskụla occlusion), kpọmkwem adịghị ala ala ọrịa.

● Secondary ma ọ bụ endogenous cachexia bu ihe nke ọrịa na-kpatara ihe ndị dị ka gipoinsulinizm (insulin erughi), mụbara njikọ nke glucagon, malabsorption (malabsorption nke nri), glucocorticoid erughi, neoplastic ibu, ngafe somatostatin.

akpata

Cachexia ọrịa emee ka a N'ihi nke a ọtụtụ ihe na ihe:
1. dịtere aka erighị na ndị agụụ na.
2. Diseases nke eriri afọ tract, karịsịa ndị na nkọlọ, nakwa dị ka celiac ọrịa, enterocolitis.
3. ruo ogologo oge na mmenaanya na brucellosis, ụkwara nta na ndị ọzọ ọrịa na-adịghị ala ala suppuration Filiks.
4. Psychogenic anorexia.
5. Disorders nke thyroid gland, adrenal insufficiency.
6. Endocrine ọrịa metụtara na metabolic ọrịa.
7. Heart ọdịda.
8. ịza aza akpụ.
9. Imefusị Oge na ụmụ.

Gịnị na-mgbaàmà nke cachexia e ji? Gịnị bụ ihe ndị a mgbaàmà?

symptomatology

E nwere ọnụ ọgụgụ nke mgbaàmà, nke e ji cachexia. Nke a na ọrịa na-eme ka anyị na ozu:
1. mberede arọ ọnwụ nke ruo 50% nke ahu aro, na n'oké ikpe karịa 50%.
2. akpịrị ịkpọ nkụ.
3. Akwara adịghị ike.
4. Disability.
5. Ụra ọrịa.
6. Mmụba meriri-efe efe.
7. ọnụ ke ọbara mgbali (ọbara mgbali).
8. Icha mmirimmiri na flabby akpụkpọ.
9. Pụrụ vitamin erughi, na eze ọnwụ.
10. trophic mgbanwe ntutu ma mbọ.
11. The mmepe nke stomatitis.
12. The omume nke afọ ntachi ruru nsia motility ọrịa.
13. The ala protein ọdịnaya nke ọbara, albumin, ígwè, B12.
14. Women nwere ike ime amenorrhea (cessation nke ịhụ nsọ).
15. Mental ọrịa.

Cachexia na psyche

Ga-amasị m na-eche banyere ọrịa uche na cachexia. Ha nwere ike na-egosipụta onwe na ogwe, ịda mbà n'obi na tearfulness na were were igba n'ime enweghị mmasị, a zuru ezu mmebi. N'oge exacerbation nke ọrịa nke kpatara cachexia pụrụ hụrụ amentia / amential syndrome (dizziness, ji enweghị ike na-elekwasị anya, jupụtara ije na ndọpụ uche, na incoherence nke echiche na-ekwu okwu) ma ọ bụ delirium (ara na nke a mmadụ bụ na a mgbe nile na-ala nke nchegbu na obi ụtọ na-ahụ ịmụ anya arọ nrọ), psevdoparalich.

Cachexia na oncology

Kansa cachexia - a syndrome na nke nọgidere mbelata skeletal muscle uka na adipose anụ ahụ na mmepe nke akpụ formations, onwe ha nke nri. Mbelata na-karịsịa akpọ ndị ọrịa nwere cancer nke eriri afọ tract ma ọ bụ n'akpa ume na akụkụ. Ndị dị otú ahụ nwere ike ida dị ukwuu dị ka 80% nke ahu aro, na-eduga ịnọrọ.

Cancer dị ka a na-akpata cachexia

Cachexia na cancer omume. The akpata cachexia nwere ike ịbụ a ngwọta. N'ihi etuto ahụ metabolism na-aghọ gbara gharịị, ime mgbanwe iji ya. The akpụ kwesịrị substrates, bụ ndị nwere ike iji hụ na ya na mmepe. Ọ bụ mba na nzuzo na cancer cachexia ọṅụṅụ na-egbu mmetụta ike anụ ahụ na akụkụ, ndị mejupụtara ha mebere atumatu ma na-eme malfunctions.

Ke kpụworo etuto ahụ na nnukwu ego nke lactic acid bụ mebiri emebi imeju. Iji normalize ịta nke lactic acid, na-amalite iji ọbara sugar, mgbe ike ka elu maka losses.

Mgbe cancer cachexia kwuru, sị:
- a kpata ajọ ọnụ ke arọ na adịghị ike;
- mebiri ịchịkwa onwe Filiks;
- Mbelata plasma cholesterol;
- mmepe nke na-efe efe ruru ka mebiri nke cellular na humoral ọgụ;
- dysphagia (ike ilo);
- vomiting, afọ ọsịsa;
- na-abawanye na ike ina;
- antidiuresis na, mmọdo, hyponatremia;
- hypercalcemia;
- ọkọ;
- abawanye na ọbara glucocorticoids;
- ụfọdụ, delirium na ọbụna amaghị onwe ya.

The esi nke cancer cachexia

Cancer cachexia dị nnọọ ize ndụ. Mụbara glucocorticoid ọbara activates Filiks gluconeogenesis (glucose njikọ) na imeju na-na muscle anụ ahụ, enwekwu mmebi nke na-edozi na abụba. N'ihi na glucose uptake site cancer mkpụrụ ndụ na-amalite hypoglycemia (ala ọbara glucose). On a ndabere (nke nwere ike kwukwara na ndị nchegbu), endocrine glands ifịk ifịk na-emepụta homonụ ngafe ego nke na-eduga igbu egbu na hemic hypoxia (belata ihe dị iche arteriovenous oxygen grajentị). Homeostatic abnormalities ime. All nke a pụrụ iduga ọnwụ.

cachexia ọgwụgwọ

Kasị nke ọgwụgwọ nke ọrịa na cachexia rụrụ ke ọgwụ ma ọ bụ clinics. Isi ọgwụgwọ na-agụnye ọgwụ ndị mkpofu neoplasms. Wires na mgbake ike, nke na-enweta site ọgaranya ahụ na vitamin, Chọpụta ọcha, abụba na-edozi. N'ihi nke a ga-eji na-adị mfe digestible oriri. Eji dị otú ahụ ọgwụ ọjọọ eme ihe: a multivitamin maka ọgwụgwọ nke hypovitaminosis, enzyme ka mma mgbaze. Food na ẹkenam na ụzọ abụọ: enteral (mgbe ọ na-abatakwa digestive tract) na parenteral (nri eleghara digestive tract). Parenteral usoro a na-eji wepụ ọrịa a ike ala (amaghị onwe) na ọgwụgwọ nke ọrịa cancer, mgbe ha, idiọk malnourished, oké na-efe efe, ilo ọrịa. N'ihi ya ndinọ glucose, vitamin, amino acid mixtures, electrolytes, protein hydrolysates (ndinọ parenterally). Ọzọkwa, na omume iji ngwá ọrụ na-amụba agụụ. Ọ bụrụ na onye ọrịa na-ata ahụhụ site na mkpọchị mgbaze nri na ya absorption, na-eji na ọgwụgwọ nke polyenzyme ọgwụ (ọgwụ ọjọọ, "Pancreatin", "ememme" ọgwụ ọjọọ).
Iji gbochie vomiting, nye iwu ka a n'aka "Delta-9-tetrahydrocannabinol". Ọ bụ irè mgbe ọgwụ. Cannabinoids dị na a nkwadebe, na-akpali agụụ, na, karị, na ibu ibu. Arọ ọnwụ nwere ike kwụsịrị iji iyak mmanụ, ya mere, ọ bụ na-a akụkụ nke ọgwụgwọ nke ọrịa ndị dị, dị ka cachexia.

Ọgwụgwọ na ọgwụ.
Iji kwụsị ịkpọ cachexia dị otú ahụ ọgwụ ọjọọ:
1) "carboxylase" - enyere normalize arọ, na-ebelata ihe mgbu ma na-akwado ahụ na usoro. Mmetụta - anabata. Ọ nwere ike ọ gaghị eji, ma ọ bụrụ na organism bụ susceptible ka ọ dịkarịa ala otu akụrụngwa.
2) "Megeys" ma ọ bụ "megestrol acetate" - akwalite na-abawanye na muscle uka na abụba. Ọ nwere ike ọ gaghị eji ma ọ bụrụ na e nwere uche na mmiri nke ọgwụ, n'ihi ndị na-n'okpuru afọ 18, n'oge ime na ara.
Na ọnụnọ nke na-efe efe na-agụnye ọgwụgwọ nke antibacterial ọgwụ. Ọ bụrụ na ọ dị mkpa, tinye anaboliticheskie homonụ. N'ọnọdụ psychogenic ọrịa aka ọgwụgwọ nke a ọrịa uche.
Anyị na-atụ na anyị zara ajụjụ gị "Cachexia - ihe ọ bụ, otú kọwaa na otú alụ agha."