"Celecoxib": ntuziaka maka ojiji, reviews. ọgwụ analogues

Ọgwụgwọ ọrịa metụtara na mmebi nke nweekwa usoro, choro site na ọgwụ ahịa ike ọhụrụ ọgwụ ọjọọ eme ihe ole na ole mmetụta na ukwuu arụmọrụ. Ọkà mmụta sayensị achọpụtawo na synthesized a ọgbọ ọhụrụ nke na-abụghị steroidal mgbochi mkpali ọgwụ ọjọọ na ndabere nke celecoxib. Ọgwụ a belata toxicity na mma anabata ahu.

Description of "Celecoxib" ọgwụ

Umi celecoxib nwere a acha odo agba na-ezo aka otu coxibs nke igosipụta nhọrọ mgbochi nke cyclooxygenase abụọ ụdị. Ọgwụgwọ dabeere na ogige nke ugbu nwere akpọ mgbochi mkpali na analgesic Njirimara. The mbụ ọgwụ na ndabere nke celecoxib na-atụle ga-mepụtara site American ụlọ ọrụ "Pfizer" ọgwụ "Celebrex". ọ bụ na-amụ ma nyochaa pharmacodynamic e ji mara nke toxicity na ahụ mmadụ.

The ọzọ ọgwụgwọ nwere n'ọrụ umi celecoxib bụ ọnyà, gụnyere iji ọgwụ "celecoxib".

onunu ogwu forms

Dị ọgwụ ike gelatin capsules na a onunu ogwu nke nọ n'ọrụ mgwa, 100 mg na 200 mg. N'adịghị ka ndị ọzọ na-abụghị steroid mgbochi mkpali mmadụ, ọ dịghị onunu ogwu ụdị dị ka ude, jel, injectable ngwọta ma ọ bụ suspensions. Mụ na ụfọdụ ndị ọrịa na-ezighị a na-akpọ ntọhapụ ụdị "Celecoxib" ọgwụ - mbadamba, ọ bụ ezie na anyị na-ekwu okwu banyere capsules.

Ọdịdị

The n'ọrụ mgwa ihe bụ celecoxib umi ke ichekwa 100 mg na 200 mg. The mejupụtara nke capsules gụnyere inyeaka mmiri na-enye ohere ndochi, na flowability na nkwụsi ike nke granulated ngwakọta. Ndị a gụnyere lactose, sodium lauryl sulfate, polyvinylpyrrolidone (K30), sodium croscarmellose, magnesium stearate.

Mmasị ka ọgwụ ọjọọ, "celecoxib" ntụziaka ntuziaka mejupụtara ihe ndị mejupụtara na e ji mara n'ile a gelatin Capsule shei. Dị ka nkọwa, ya anya dull, nwere fọrọ nke nta na-acha ọcha na agba na-akara na ihe ịrịba ama "100" ma ọ bụ "200", emi odude ke-acha anụnụ anụnụ ma ọ bụ odo gbalaga, karị. Nke a na-enye ohere ịmata capsules na dị iche iche Dosages. Mejupụtara nke odo odo na-acha anụnụ anụnụ ink na-ese zuru ezu na-egosi e ji esiji ákwà na-adịghị njọ ka organism.

yiri ọgwụ ọjọọ

Medicinal ngwaahịa "Celecoxib", analogues nke nke e tinyere n'ọrụ umi celecoxib, nwere ike igosipụta otu ọgwụgwọ utịp ke osteoarthritis nke mmadụ ọkpụkpụ.

The mbụ ọgwụ "Celebrex" na ya ọnyà "Celecoxib", "Artoksib", "Zitsel", "Revmoksib", "Ranseleks" na-atụle kennyeghari ọgwụ. Otú ọ dị, na mbụ price Atiya ga-eri ihe iji nke ịdị ukwuu oké ọnụ karịa ndị ogbo ha.

Na nkwadebe "Celebrex" nwere celecoxib na a onunu ogwu nke 100 na 200 mg dị ka a agwọ ọrịa "celecoxib". Inyeaka mmiri nke Capsule na ya envelopu nwere ike iche ma na qualitative na quantitative mejupụtara nke na-adịghị emetụta ha Njirimara. Banyere ụdị ntọhapụ nke ọnyà "Celecoxib" ọgwụ analogues na-emepụta naanị na ike gelatin capsules maka esịtidem were.

E nwere ndị na-abụghị steroidal mgbochi mkpali mmadụ, cyclooxygenase dokwara ọdabara nke abụọ ụdị ma na-enwe dị iche iche na ihe ndị mejupụtara nke nọ n'ọrụ akụrụngwa, ndị pharmacokinetic na pharmacodynamic e ji mara. A na-agụnye sulfonamide compound nimesulide nke na a kwa ụbọchị onunu ogwu nke 200 mg irè emeso mgbaàmà nke osteoarthritis na ọrịa ogbu ogbu na nkwonkwo. Formulations dabere na ya mgbochi mkpali na analgesic mmetụta site inhibiting na cyclooxygenase abụọ na a nta ruo n'ókè - nke mbụ ụdị, na-emetụta a dịgasị iche iche nke ndị ogbugbo nke mgbu na mbufụt.

Ka nimesulide, celecoxib bụ nnọchiteanya nke sulfonamide klas nke bekee, na-na a kwa ụbọchị onunu ogwu nke 200 mg eliminates mgbaàmà nke osteoarthritis. Ọ na-adịghị inhibit cyclooxygenase mbụ ụdị na omume na a ole na ole nke ndị ogbugbo nke mgbu na mbufụt.

Otu ọzọ ọgwụgwọ coxibs onu ochichi bụ injectable forms of NSAIDs. Otu n'ime ndị isi na uru nke "Celecoxib" ngwaahịa - na price. Ọgwụ (ampoules maka ọgwụ) ọzọ na-abụghị steroidal mgbochi mkpali ọgwụ ọjọọ na-eri ihe dị oké ọnụ, ma ndị dị otú injection arụmọrụ karịrị nnọọ n'ihi si eji ọgwụ ọjọọ eme ihe na ihe siri ike iche-iche.

usoro nke ihe

Drug "Celecoxib" - a ọgwụ na-anọchite anya a ọgbọ ọhụrụ nke ndị so ná ndị mgbochi mkpali mmadụ, mgbochi mkpali, analgesic, antipyretic ọrụ. Ya usoro nke edinam jikọtara igbochi guzobe mkpali prostaglandins site na mbenata ọrụ nke Cox-2.

Mkpali Jeremaya mere ịkpalite itinye n'ọkwa nke cyclooxygenase abụọ ụdị, n'aka accelerates ìgwè prostaglandin njikọ na bekee welie mbufụt. State amalite ọkọ na ihe mgbu.

Cyclooxygenase mbụ ụdị adịghị emetụta ọgwụgwọ dose "celecoxib" nkwadebe. Ntuziaka maka ojiji na-akọwa inertia nke ọgwụ na-akwanyere a enzyme jikọtara ya na-eme nke n'ahụ Filiks aa na mkpụrụ ndụ nke eriri afọ tract na platelet owuwu.

Ọzọkwa, na ntuziaka nyere data na mmetụta nke ọgwụ ọjọọ na akụrụ ya. N'okpuru ihe nke celecoxib bụ ihe na-erughị egosipụta na mmamịrị mejupụtara prostaglandin E2 na F1 nke 6-keto-prostaglandin, ma ọ dịghị agbanwe oke nke B2 11-dehydro-thromboxane, nke na-egosi nhọrọ mmetụta ọgwụ.

Iji ọgwụ ọjọọ, "Celecoxib" adịghị eduga a ọnụ na filtration ọnụego na akụrụ glomeruli agadi na na ọrịa na gbasara akụrụ insufficiency.

Egosi maka ojiji

Dị pharmacodynamic e ji mara nke nkwadebe "celecoxib" ngwa ọ ga-adị irè maka ọgwụgwọ nke ọrịa ogbu na psoriatic ogbu na nkwonkwo, na-adịghị ala mbufụt na mgbu nke ọkpụkpụ azụ na sacroiliac nkwonkwo na osteoarthritis.

Ruru ya analgesic Njirimara na-eji maka na-egbu mgbu ọnọdụ na nweekwa ihe mgbu mgbe ịwa ahụ ọgwụgwọ, dysmenorrhea, nke na-esonyere na-egbu mgbu nanso. The mgbochi mkpali mmetụta nke ọgwụ na-iji na mbenata outgrowths na polyps na colon na ikensi na nchoputa nke "adenomatous polyposis".

Olee na-

Were na nkà mmụta ọgwụ "Celecoxib" ntuziaka maka ojiji n'ime aro bụghị ejikọta na oriri nke nri. The capsules anaghị emeghe na bụghị-ata ata, ma loo dum site na-aṅụ ọtụtụ mmiri.

Karịa ego nke celecoxib, nke nwere ike iwere kwa ụbọchị bụ 0.4 g Nke a nkwadebe na-eji na ngafe naanị na obere okwu.

Obi nsogbu nwere ike ime ka elu doses na ruo ogologo oge ọgwụgwọ na ọgwụ "Celecoxib". Guide nwere ozi na obere Dosages maka symptomatic omume nke ọ bụla na-agụ. Na-enye na-atụ aro na obere were.

Iji kpochapụ ihe mgbaàmà jikọtara osteoarthritis, na ankylosing spondylitis, kwa ụbọchị iri otu ma ọ bụ ugboro abụọ na 200 mg nke ọgwụ.

Iji kpochapụ ihe mgbaàmà nke ọrịa ogbu ogbu na nkwonkwo eji a kwa ụbọchị dose nke 200 ma ọ bụ 400 mg, nke e weere dị ka ugboro abụọ.

Mgbu na isi dysmenorrhea na-emeso ke akpa usen ndị dị elu dose of 400 mg, na o kwere omume n'ikuku nke a n'ihu 200 mg, kwa ụbọchị iji 200 mg 2 ugboro n'ụbọchị.

Ndị agadi, na ndị ọrịa na-enwe nwayọọ ogo ezughi oke imeju ma ọ bụ nwayọọ na agafeghị oke gbasara akụrụ insufficiency, ọ dịghị recalculation nke dose a rụrụ.

Low arọ (erughị 50 n'arọ), nkezi ogo mmebi imeju - data ige maka ọrịa emeso ya na ala doses nke ọgwụ ọgwụ.

A, maka ọgwụgwọ nke mkpali Filiks ke nkwonkwo eji ọgwụgwọ usoro dabere na ojiji nke ọtụtụ ọgwụ ọjọọ dị iche iche onunu ogwu iche-iche. Ikpokọta "celecoxib" Capsule, ude, ma ọ bụ jel-ụdị okpomọkụ "Apizatrona" ma ọ bụ "finalgon. Nde eji na-akpata a nwa oge mmetụta, n'ihi ya, ha na-eji ọnụ na ọgwụ ọjọọ maka ime ụlọ n'ikuku.

Nke a machibidoro ojiji nke

Ọ bụghị ihe niile ọrịa na ọrịa nke nkwonkwo, i nwere ike na-ọgwụ ọjọọ, "Celecoxib". Ntuziaka maka ojiji nwere a ndepụta nke ọrịa na ọnọdụ nke na ngwá ọrụ ga nsogbu karịa mma. Ndị a gụnyere:

• aṅụ, ụkwara ume ọkụ, nfụkasị ọnọdụ site n'oru nke aspirin na ndị ọzọ na ndị so ná ndị mgbochi mkpali ọgwụ ọjọọ;
• mgbake ọrụ metụtara na akwara akwara uzo grafting ;
• exacerbation nke peptic ọnyá afọ;
• afo na nsia ọbara ọgbụgba;
• mbufụt nke mucosa na eriri afọ;
• obi odida;
• ischemic ọrịa obi muscle;
• ọnwụ nke elu akwara ndị gara na-arịa ọrịa arịa na mkpọchị ụbụrụ ọbara;
• hepatic nedostatochnosttyazheloy udi;
• oké gbasara akụrụ odida;
• ịmụ nwa, nwa;
• ara nwa;
• n'okpuru afọ iri na asatọ afọ;
• hypersensitivity ka excipients;
• ụba susceptibility na sulfonamide akụrụngwa.

Na-akpachara anya na ojiji nke ọgwụ ọjọọ, "Celecoxib" ga-abụ ndị na ọrịa nke eriri afọ tract metụtara na peptic ọnyá afọ ọbara ọgbụgba na n'oge gara aga, ọrịa nke mucous bacteria nke genus Helicobacter pylori.

mmiri njigide na ahu na nro na nsụkọrọ edema, ọrịa imeju nke abụọ ogbo, obi na vaskụla ọrịa, na ahụ, nke na-abawanye na cholesterol larịị ke ọbara plasma hụrụ lipid metabolism, ọrịa shuga, sugar, somatic ọrịa na oké, na-a na-akpata nke kacha imefusi ọgwụ "celecoxib" n'okpuru nlekọta nke a dibịa.

mmetụta

N'agbanyeghị na otutu rụzuru na e kere eke nke a ọgbọ ọhụrụ nke coxibs, ndị a bekee na ọgwụ ọjọọ dabeere na ha na-adịghị nke na-enweghị mmetụta.

Soro ọgwụ "Celecoxib" ntuziaka maka ojiji, ndidi testimonials na ọkachamara - ndị a nwere ozi banyere omume oghom mmetụta ahụ nwere ike ime na dị oké mkpa akụkụ.

The kwere omume na-ezighị ezi mmetụta na digestive usoro ji NSAID-gastropathy, ihe mgbu ke afo, ọgbụgbọ, vomiting, nrekasi obi, ibelata mkpa maka nri oriri na afọ ọsịsa. Ogologo oge eji nke elu doses nwere ike ime ka mmerụ ahụ na ọbara na-agba na mucous akpụkpọ ahụ nke afo na eriri afọ ya, na-agba ọbara goms, oké ebighị nke transferase imeju.

Ụjọ ọrịa na-egosipụta obi ụtọ, isi ọwụwa, dizziness, somnolence, ehighi ura, dara ya mbà na-ekwu.

Mmetụta na obi usoro ruru ka ịmanye na akwara, na tachycardia.

Nkwadebe "celecoxib" ebelata iguzogide ọrịa na nke akụkụ okuku ume usoro, nke nwere ike owụt ke mmepe nke Sinusitis, rhinitis, pharyngitis, ihe mgbu na imi na akpịrị, ụkwara, dyspnea, bronchospasm.

Mmetụta nke ọgwụ na uche ziri ezi na-akpata a gụnyere ya ná auditory nghọta na ọdịdị tinnitus.

Na urinary usoro emetụta ọgwụ "Celecoxib" ka unu wee na-enweta gbasara akụrụ odida na mmepe nke edema syndrome.

Banyere na-akpụ ọbara akụkụ, ọgwụ nwere ike ime ka mpụta ìhè nke agranulocytosis, anaemia, leucopenia, thrombocytopenia.

Skin rashes nwere ike ime na ọdịdị anabata pruritus, urticaria, photosensitivity, angioedema na ọdịdị ihu na mpaghara, na nsọtụ, genitalia.

atụmatụ n'ikuku

Drug "Celecoxib" pụta ụwa mwepu metụtara na ihe ize ndụ nke oghom mmetụta na obi usoro eduga thrombosis, infarction nke myocardial pụtara na muscle na ọrịa strok. Karịsịa ihe ize ndụ na-abawanye n'oge na-adịghị ala ochichi nke ọgwụ site ọrịa na onye na-ọrịa obi.

Iji belata ihe ize ndụ nke dị otú ahụ nsogbu na ọrịa na-ewere ọgwụ ọjọọ, "Celecoxib" nye iwu kasị ala dose na kasị mkpirikpi ọgwụgwọ. Onye ọrịa ga-atụle na dọkịta gị pụrụ ịrịba ama nke ọrịa na-enweta ndụmọdụ banyere otú meghachi omume mgbe ha emee.

iji a Nchikota acetylsalicylic acid na ntakiri doses ọgwụ "celecoxib" Iji belata obi mgbaàmà. Nyocha nke dọkịta na-egosi na antiplatelet mmetụta nke aspirin ka mkpa ọbara mgbe ewere coxibs, nke na-adịghị dị otú ahụ na-emegide thrombotic Njirimara. A, ndị dị otú ahụ a Nchikota gosiri na agadi ọrịa na-anaghị ekwe nke nweekwa usoro na obi usoro, eriri afọ toxicity na-ụba mgbe ndị na-abụghị nhọrọ ndị na-abụghị steroidal mgbochi mkpali ọgwụ ọjọọ. Ma were nke a umi celecoxib na ndị ọzọ NSAIDs adịghị atụ aro.

Maka ọrịa na-ata ahụhụ site na ọbara mgbali elu, na-aga n'ihu nlekota nke a oke mgbe inweta "Celecoxib" ọgwụ ọjọọ.

Akpan akpan ntị ga-enye nlekota ọnọdụ nke organism na Nchikota na anticoagulant (warfarin) na antiplatelet bekee (acetylsalicylic acid, clopidogrel) iji nhọrọ inhibitors (citalopram, sertraline), inhibiting serotonin reuptake inhibitors nke CYP2C9 isozyme, mbadamba forms glucocorticosteroids.

Ọgwụ "celecoxib" na-akwalite mmepụta nke prostaglandin bekee, nke ghara mmiri mmiri na ahụ na-akwalite mmepe nke edema. Karịsịa ịkpachara anya na ọgwụgwọ nke ọgwụ ndị a dị mkpa ka ndị mmadụ na-ata ahụhụ si na obi muscle odida na ọbara mgbali elu. kwesịrị ịkwụsị ewere "Celecoxib" ọgwụ ọjọọ ma ọ bụrụ na e nwere ihe ịrịba ama nke ọzịza nke arọ.

Ọrịa na akụrụ ọrịa ọgwụgwọ coxibs ga-esonyere elekọta ya mgbe nile nke ha isi na-egosi.

Mgbe akpịrị ịkpọ nkụ na-ewere ọgwụ bụ omume nanị mgbe rehydration N'ezie rehydration.

N'ikuku "celecoxib" antipyretic ọgwụ n'ihi edinam na-eduga ná sikwuoro nke na-achọpụta ọrịa index, dị ka elu okpomọkụ n'oge mmepe nke na-efe efe na ọnọdụ.

The edinam nke ọgwụ nwere ike ime ka abnormalities na imeju ọrụ, karịsịa ndị na-tupu ẹdude ọrịa nke imeju. Siri ike mgbaàmà jikọtara fulminant ịba ọcha n'anya, imeju nekrozomtkaney. Ndị dị otú ahụ ọnọdụ ime ozugbo, ma nanị mgbe 30 ụbọchị mgbe ngwa "celecoxib" nkwadebe. Mgbe ahụ ị chọrọ nyochaa arụmọrụ na ọgwụgwọ nke imeju nke a owuwu, na na ikpe nke na arọ wee merie gị ga ozugbo kagbuo oru.

Nyocha maka ọgwụgwọ nke "Celecoxib"

Ndị so ná ndị mgbochi mkpali ọgwụ ọjọọ na-rụrụ naanị na ndenye ọgwụ. The results nke eji "Celecoxib" ọgwụ reviews nke ya edinam bụ mbuaha. Otu ọgwụ na-enyere aka ịnagide mkpali Filiks ke nkwonkwo, maka ndị ọzọ, ọ bụ adighi ike na-akpata a ọnụ ọgụgụ nke oghom ihe.

Dị ka ndị ọrịa inwale ọgwụ "Celecoxib"? Nyocha na-egosi a ọnụ ọgụgụ nke nsogbu: mgbu na afo, akụrụ, ịhụ nsọ ọrịa. Ndị dị otú ahụ ọrịa dibịa enịmde kagbuo agwọ ọrịa na nyere ọzọ ọgwụgwọ.

Dabere na echiche nke ọrịa na mmetụta nke ọgwụ ọjọọ na nkwonkwo, ọ nwere ike kwubiri na ọ bụ irè na-alụ megide ogbu na nkwonkwo. Iji kpochapụ ihe mgbu mgbaàmà, ọzịza nke anụ ahụ nọ n'ógbè nke a adịghị ala ala uwa, ndị ọrịa bụ ndị na ụbịa na mmiri ọnụego nke usoro ọgwụ "Celecoxib". Ọ na-eji na-eme egwuregwu na trauma na nkwonkwo.

Karịsịa agwọ ọrịa eme ihe n'ụzọ dị irè na Nchikota na Okpomoku ointments na gels maka Nde ngwa. Otú ọ dị, dị ka na-atụ aro ndị dị na ntuziaka maka ojiji nyere NSAID iji obere ọmụmụ, iji zere nchegbu na akụrụ, imeju, obi na afo. Ma ọ bụghị bụghị iji zere emeghị nke ọma na-arụ ọrụ nke ndị a na ozu.