Antidiuretic hormone (ADH). The secretion nke antidiuretic hormone

Vasopressin - antidiuretic hormone - emepụta site na hypothalamus, bụ nke dị na posterior pituitary (neurohypophysis). Nke a hormone ana achi achi homeostasis na ahụ mmadụ, ịnọgide na-enwe mmiri itule. Ya mere, ihe atụ, akpịrị ịkpọ nkụ ma ọ bụ oke ọbara ọgbụgba n'okpuru nduzi nke vasopressin agụnye usoro iji hụ na cessation nke ọmụmụ na ọnwụ. N'ihi ya, antidiuretic hormone (ADH) nanị adịghị ekwe ka anyị nkụ.

Ebe ADH na-synthesized?

Antidiuretic hormone-emepụta nnukwu cell akwara ozi nke supraoptic ntọala nke hypothalamus na-ejikọ na neyrofizinom (ụgbọelu-protein). Ọzọkwa, ọ na-eduzi kwupụta n'azụ n'ọnụ ọnụ nke hypophysis na e imubanye na hypothalamic akwara ozi. Dị ka mkpa si n'ebe ọ abatakwa ọbara. ADH secretion na-emetụta:

1. Ọbara mgbali (BP).
2. na plasma osmolarity.
3. Olu nke ọbara ekesa ke idem.

Ndu mmetụta nke mgbochi mamịrị hormone

Mgbe elu ọbara mgbali secretion nke antidiuretic hormone ewute na ọzọ, ọdịda na ọbara mgbali site 40% of nkịtị vasopressin njikọ nwere ike mụbara site na mbụ mkpa kwa ụbọchị 100 ugboro.

na plasma osmolarity na-na metụtara electrolyte mejupụtara ọbara. Ozugbo osmolarity ọbara dara n'okpuru kacha nta na-anabata ụkpụrụ, amalite ubara oke nke vasopressin n'ime ọbara. Na-abawanye na plasma osmolality n'elu ime norms nwoke mmiri na-agụ. A ojiji nke nnukwu quantities nke mmiri mmiri suppresses na ọdịda nke hormone. N'ihi ya, nchedo a rụrụ site akpịrị ịkpọ nkụ.

Olee antidiuretic hormone na-emetụta mgbanwe na olu nke na-ekesa ọbara? Ọ bụrụ na ọbara gwụrụ pụrụ iche na-anabata ya dị na ekpe atrium na-akpọ volyumoretseptorami zaghachi a ọnụ ke ọbara olu na ọbara mgbali dobe. Nke a mgbaàmà abatakwa neurohypophysis na-agbake vasopressin abawanye. The hormone na-akpa ihe na ọbara arịa na ha na-anabata ya asụchikwa na lumen. Nke a na-eme ka cessation nke ọbara ọgbụgba na n'ihu na-egbochi dobe ke ọbara mgbali.

Imebi nke njikọ na secretion nke ADH

Ndị a na-anaghị ekwe nwere ike ejikọta ya na ihe ezughi oke ọnụ ọgụgụ nke vasopressin ma ọ bụ ya ngafe. Ka ihe atụ, na-arịa ọrịa shuga insipidus e nwere onye na-ezughi oke ozo nke ADH, mgbe syndrome Constantin Ion Parhon ya overabundance.

arịa ọrịa shuga insipidus

Na ọrịa a, gbasara akụrụ reabsorption mmiri mbelata n'ike n'ike. Nke a nwere ike facilitated site abụọ ọnọdụ:

1. Na-ekwesịghị ekwesị secretion nke vasopressin - mgbe ọ na-abịa ọrịa shuga insipidus of Central malite.
2. Belata akụrụ omume ADH - a na-eme mgbe a neurogenic ụdị ọrịa shuga insipidus.

Ọrịa na-ata ahụhụ site na nke a daa ọrịa kwa diuresis pụrụ iru 20 lita. Mmamịrị mgbe ala-ịta. Ọrịa na-mgbe niile mmiri na-agụ na ha na-aṅụ a otutu ọmụmụ. Iji chọpụta ihe ụdị a ụdị ọrịa shuga insipidus ndidi na-ata ahụhụ, na-eji ihe analogue nke hormone vasopressin - a ọgwụ ọjọọ, "desmopressin". The ọgwụgwọ mmetụta nke ọgwụ na-egosi na na Central ụdị ọrịa ahụ.

syndrome nke na-ekwesịghị ekwesị antidiuretic hormone secretion

Ọ na-akpọ syndrome nke na-ekwesịghị ekwesị secretion nke ADH. The ọrịa na-esonyere oké secretion nke vasopressin, mgbe e nwere a belatara osmotic mgbali nke ọbara plasma. N'ihi ya, ọ na-esonụ mgbaàmà:

• Akwara twitching na cramps.
• Ọgbụgbọ, enweghị agụụ, na o kwere omume vomiting.
• Ekwe Omume lethargy, amaghị onwe ya.

Ndidi ọnọdụ ga-adị njọ mgbe ahụ ọmụmụ (intravenously ma ọ bụ n'ime ihe ọṅụṅụ). Mgbe oké mmachi nke ọmụmụ oriri na kagbuo igba ogwu n'akwara infusion na ọrịa kwụsịtụkwara.

Gịnị mgbaàmà na-egosi ihe ezughi oke ozo nke vasopressin?

Ọ bụrụ na antidiuretic hormone na-synthesized ụkọ, ndị mmadụ nwere ike inweta:

• Nnọọ mmiri na-agụ.
• Ugboro urination.
• Nkụ nke anụ, nke na-aga n'ihu mgbe nile.
• Enweghị agụụ.
• Nsogbu na eriri afọ tract (mgbu, afọ, afọ ntachi).
• Nsogbu na mmekọahụ okirikiri. The ndị ikom - belata potency na ndị inyom - menstrual ọrịa.
• -Adịghị ala ala ike ọgwụgwụ.
• Mụbara intracranial nsogbu.
• Belata ọhụụ.

Dị ka e gosiri site a ọnụ nke ADH?

Mbelata ke ọbara vasopressin nwere ike ime ndị na-esonụ ọnọdụ:

• Central-arịa ọrịa shuga insipidus.
• Nephrotic syndrome.
• Psychogenic polydipsia.

Gịnị bụ ihe mgbaàmà Point na ụba secretion nke ADH?

• Belata kwa diuresis (mmamịrị mmepụta).
• Ibu ibu na a belatara agụụ.
• Lethargy na dizziness.
• Isi ọwụwa.
• Ọgbụgbọ na vomiting.
• Akwara cramps.
• Dị iche iche na ọnya nke ụjọ usoro.
• ụra disturbances.

N'okpuru ihe ọnọdụ kwuru, na-abawanye na larịị nke ADH?

The abawanye nke vasopressin nwere ike hụrụ pathologies ji oké secretion nke hormone, ha na-agụnye:

• Julien-Barre syndrome.
• Intermittent nnukwu porphyria.

Ke adianade do, ọ bụ ike n'okpuru ndị na-esonụ ọnọdụ:

• akpụ ụbụrụ (isi ma ọ bụ metastases).
• Ọrịa nke ụbụrụ.
• Vaskụla ọrịa nke ụbụrụ.
• Tuberculous meningitis.
• Oyi baa.

Antidiuretic hormone - ebe ọ chịlie aka elu?

Otu n'ime ndị kasị dị irè maka mkpebi siri ike nke ADH na ọbara bụ a radioimmunoassay (Ria). Ẹbiet chọpụta osmolarity ọbara plasma. The analysis nwere ike mere ọ bụla Endocrinology center. Ọtụtụ onwe clinics na-eme dị otú ahụ chọpụtara. Blood si mesoo si a akwara n'ime akpa enweghị ihe ọ bụla nchekwa.

Tupu nnyefe nke ọbara na antidiuretic hormone kwesịrị 10-12 hour ezumike na nri. Anụ ahụ na uche nchegbu na eve ọbara onyinye nwere ike agbanwe analysis. Nke a pụtara na ụbọchị tupu nnyefe nke analysis ọ bụ ihe amamihe na-na-arụ dị arọ na-arụ ọrụ, ọ bụghị iji na-ekere òkè n'egwuregwu asọmpi, bụ ka ha ghara iji ule, wdg

Ọgwụ ndị na ike dịkwuo larịị nke ADH, a ga-ekpochapụ. Ọ bụrụ na nke a agaghị ekwe omume n'ihi na ihe ọ bụla mere, arịrịọ forms dị mkpa ezipụta ihe ọgwụ e ji, mgbe na ihe dose. Ịgwagbu ata larịị nke ADH nwere ike ndị na-esonụ ọgwụ ọjọọ:

• estrogens;
• ọgwụ ụra;
• ọgwụ na-akụnwụ;
• tranquilizers;
• "Morphine";
• "Oxytocin";
• "Cyclophosphamide";
• "Carbamazepine";
• "Vincristine";
• "Hlorpropamid";
• "Chlorothiazide";
• "Lithium carbonate".

Analysis nke antidiuretic hormone nwere ike iwere dịghị tupu otu izu mgbe radioisotope ma ọ bụ radiological nnyocha.

Nke a na-amụ na-enye ohere ka anyị na-ọdịiche dị nephrogenic ọrịa shuga insipidus na pituitary ọrịa shuga insipidus na ọrịamkpokọta ji oké secretion nke ADH.