"Azathioprine": ntụziaka ntuziaka, reviews, nkọwa, analogs

Nke na-akpọ maka ọgwụ "Azathioprine"? Ntuziaka na ngwa osụk site elekọta mmadụ ga-a kọwara n'isiokwu a. Anyị na-agwa gị ma ị na e nwere contraindications na analogues nwere a ọgwụ, ihe ọ na-efu, ihe ga-eme banyere ihe ovadozu, na na. D.

Mejupụtara, nkwakọ, udi, nkọwa agwọ ọrịa

Na ihe n'ụdị dị ọgwụ "Azathioprine"? Ntuziaka maka ojiji na-egosi na nke a na nkà mmụta ọgwụ dị na mbadamba ụdị. Ha n'ọrụ mgwa eme dị ka azathioprine. Na-na ọgwụ ọjọọ na-agụnye ndị ọzọ Efrata na ụdị nduku starch, gelatin, lactose, na calcium stearate.

Na a ngwugwu ere ọgwụ "Azathioprine"? Ntuziaka maka ojiji nke ọgwụ na-nchọ na a kaadiboodu igbe, nke enịm acha odo Valium ọgwụ na ọnya Ukwu nke 50 iberibe.

Pharmacological e ji mara agwọ ọrịa

Gịnị bụ nke a na nkà mmụta ọgwụ dị ka "Azathioprine"? Ntuziaka maka ojiji, n'ezie na ahụmahụ ndị ọkachamara haa na ọgwụ na ajụjụ bụ ihe analọg "hypoxanthine", "ebe adenin" na "Gwanine", gụnyere ke Ọdịdị nke nucleic asịd na igosipụta a igbochi mmetụta na ikwu na anụ ahụ proliferation na cell nkewa.

"Azathioprine" - immunosuppressive n'ụlọnga. Ya edinam iji na cellular cytotoxicity.

Weere a ọgwụ ike inhibit mmeghachi omume nke anụ ahụ incompatibility na-emetụta replication nke-alụso ọrịa ọgụ, kama ọ bụ naanị na a obere ókè. Tụnyere "mercaptopurine" ifịk ifịk ọgwụ na-egosipụta a ọzọ akpọ.

Pharmacokinetic ọgwụ

Mgbe onu ọgwụ na-ọma etinye obi gị dum na eriri afọ tract. Ọ nwere a ala nkekọ na plasma-edozi (odika 30%).

The biotransformation nke ọgwụ ntọhapụ emee na tioinozinovoy acid na mercaptopurine (i.e., ifịk ifịk metabolite). The obere ego nke ọgwụ n'ime anụ ahụ. Na nke a, a obere ịta nke ọgwụ hụrụ na ụbụrụ.

The ọkara ndụ nke azathioprine, na ya nọ n'ọrụ metabolites bụ banyere 6 awa. The kasị elu ịta nke ọgwụ na ọbara hụrụ mgbe 70-110 nkeji.

The ọgwụ na-fọrọ nke nta kpamkpam atara ọnụ na bile, na naanị 1-2% - site na akụrụ ya.

egosi mbadamba

Gịnị prescribers "Azathioprine" (ntuziaka maka ojiji nke ọgwụ ọjọọ, analogs, reviews ga-ọkọnọ e mesịrị)? Nke a nkwadebe-egosipụta onwe ya n'ụzọ dị irè mgbe ndị na-esonụ abnormalities:

• psoriasis;
• ọrịa ogbu ogbu na nkwonkwo;
• red systemic lupus erythematosus ;
• ọnyá afọ;
• dermatomyositis;
• myasthenia gravis;
• Pemphigus rụrụ arụ;
• periarteritis nodosa;
• Crohn ọrịa ;
• glomerulonephritis, autoimmune;
• adịghị ala ala ifịk ịba ọcha n'anya;
• Reiter si syndrome ;
• purpura mgbawa thrombocytopenic.

Ọ kwesịkwara kwuru na nke a usọbọ na-kenyere mgbochi nke transplant jụrụ. Ma na nke a na e were ya na Nchikota na ndị ọzọ ọgwụ.

Contraindications iji ọgwụ ọjọọ eme

Ntuziaka maka ojiji nke ọgwụ ọjọọ, "Azathioprine" na-agwa ndị ọrịa banyere ndị na-esonụ contraindications:

• hepatic ọdịda ;
• hypersensitivity-arụsi ọrụ ike ma ọ bụ nke inyeaka mmiri ọgwụ;
• n'oge ime;
• ọnọdụ nke ndị na-emegbu emegbu hematopoiesis;
• ụmụ afọ;
• ara.

Agwọ ọrịa "Azathioprine": Ọnụọgụ ọgwụ na ochichi

Were "azathioprine" mbadamba kwesịrị na ndinọ ọnụ. Na nke ọ bụla, ndị dose nke ọgwụ kpebisiri ike n'otu n'otu, dabere na àmà ndị e nwere, nakwa dị ka ogo nke ọrịa na concomitant ọgwụ.

N'ihi mgbochi nke aka ịjụ ọgwụ kenyere na Nchikota na "cyclosporin" na corticosteroids. Ná mmalite nke na-ewere ọgwụ ọgwụ na a loading dose na bụ 5 mg kwa n'arọ (ihe karịrị ọnwa abụọ). Ekemende aṅụ ọgwụ na mmezi dose (1-4 mg kwa n'arọ na 3 doses). A, ndị dị otú ahụ na-aga n'ihu n'ihi na a ogologo oge. Ọ bụrụ na ị kagburu ọgwụ dose ọgwụ na-lowered nwayọọ nwayọọ.

Na omume nke mbụ ihe ịrịba ama nke jụrụ dọgharịala ngwa a chọrọ dịkwuo kwa onunu ogwu nke agwọ ọrịa ọzọ na 4 mg kwa n'arọ.

Maka ọgwụgwọ nke ọrịa ndị ọzọ agwọ ọrịa na-ejikarị ndinọ na a kwa ụbọchị dose nke 1.5-2 mg kwa n'arọ 4 kewara doses. Ọ bụrụ na ọ dị mkpa, kpọmkwem ego nke ọgwụ nwere ike mụbara ka 200-250 mg (kewara 4 doses). Na oge nke ọgwụgwọ na ngwá ọrụ a na-emekwa n'otu n'otu, ahụmahụ ọkachamara.

Olee otú iji "Azathioprine" (mbadamba) na ọrịa ogbu ogbu na nkwonkwo? Ntuziaka maka ojiji, ratings (kọwara nkwadebe e gosiri n'elu) na-ekwu na maka ọgwụgwọ nke ọrịa ndị dị kenyere 1-2.5 mg kwa n'arọ kwa ụbọchị (kewara 2 doses). Duration nke ọgwụ kwesịrị dịkarịa ala ọnwa 3. Dị ka na-akwado ndị ọrịa e nyere a dose of 0,5 mg kwa n'arọ (otu dose).

Maka ọgwụgwọ nke ala ala ịba ọcha n'anya B (ifịk) nye iwu a kwa ụbọchị dose nke 1-1.5 mg kwa n'arọ.

Ikpe nke ọgwụ ovadozu

Gịnị bụ ihe mgbaàmà nke ovadozu ime na-ezighị ezi n'ikuku "Azathioprine" ọgwụ ọjọọ? Ntuziaka maka ojiji, n'ezie na ahụmahụ dọkịta ikwu na elu dose nke ọgwụ nwere ike ime ka dị iche iche dyspeptic ala, pancytopenia, ọrịa nke imeju ọrụ na ime ndị ọzọ mmetụta nke ọgwụ.

Dị ka ọgwụgwọ nke ndị dị otú ahụ phenomena iji symptomatic ọgwụ. Ọ bụrụ na ọ dị mkpa, hemodialysis. Otú ọ dị, mara na a usoro anaghị ekwe nkwa ido zuru mkpochapu ifịk umi site n'ahụ mmadụ.

ọgwụ interactions

Dị ka ndị ọzọ ọgwụ ọjọọ na-emetụta ọgwụ "Azathioprine"? Ntuziaka maka ojiji na-ekwu na-ngalaba-ochichi nke gị n'ụlọnga na "Allopurinol" nwere ike welie nsí mmetụta nke mbụ, na na njikọ na "co-trimoxazole" akpatakarị ụba myelotoxic mmetụta.

Imekotaotuugbo ọgwụgwọ na Ace inhibitors enwekwu ihe ize ndụ nke oké leukopenia.

Na Nchikota na ndị ọzọ immunosuppressants (e.g., "Cyclosporins", glucocorticoids, mgbochi CD3-alụso ọrịa ọgụ) nke ukwuu mgbe nwere a dịgasị iche iche nke neoplasms na-efe efe.

E lee ya anya nkwadebe na-egosipụta na-emegide ihe ndị nedepolyarizuyushim muscle relaxants.

Ọ kwesịkwara kwuru na ịgba ọgwụ mgbochi ọrịa n'oge ọgwụgwọ "azathioprine" pụrụ nnọọ n'ụzọ dị mfe ịkpata ndị suppression nke mmepụta nke-alụso ọrịa ọgụ (bụrụ na nke inactivated ọgwụ mgbochi), nakwa dị ka dịkwuo malitere ịrịa replication (na iwebata ndụ ọgwụ mgbochi).

kpọmkwem na-atụ aro

Ihe mara tupu ị na idepụta ọgwụ "Azathioprine"? Ntuziaka maka ojiji, ezigbo (analogues ọgwụ e depụtara n'okpuru ebe) ikwu na n'oge mbụ na nke abụọ ọnwa nke ọgwụ a chọrọ izu ọ bụla na-edebe ụkpụrụ nke elu ọbara. Mgbe oge a, na-amụ ihe na-egosi na mmiri na a ugboro ole nke 1 bụla ụbọchị 30.

Ọ dịkwa mkpa inyocha larịị nke bilirubin, alkaline phosphatase na imeju na enzymes.

Na ọnụnọ nke abnormalities nke akụrụ ma ọ bụ imeju, nakwa dị ka a na nkwonkwo n'ikuku na "Allopurinol" agwọ ọrịa onunu ogwu n'okpuru echiche ga-ebelata ka 1/4 akụkụ.

"Azathioprine" ihe ókè ịkpachara anya kenyere ndị ọrịa bụ onye herpes zoster, chikinpoksi, xanthine oxidase erughi, na n'oge okpomọkụ ma ọ bụ cytotoxic ọgwụ.

Analogues na ọgwụ price

Gịnị nwere ike dochie anya "Azathioprine"? Ntuziaka maka ojiji (price nke ọgwụ ndị e depụtara n'okpuru ebe a) na-ekwu na weere ọgwụ nwere ole na ole ndị ọgbọ. The kasị yiri na mmetụta na-agụnye ndị na-esonụ ọgwụ:

• "Alpha-fetoprotein."
• "Alfetin".
• "Stemokin".
• "Profetal".
• "Revlimid".

Ma ihe ndị price, mgbe ngwaahịa a bụ bụghị nnọọ elu. 50 mbadamba "azathioprine" na nkezi bụ banyere 230 Russian rubles.

Nyocha nke agwọ ọrịa

A ole na ole reviews nke ọgwụ "Azathioprine" pụtara mbuaha. Ụfọdụ ndị na-ewere ọgwụ n'ihi otu autoimmune ọrịa, nwere afọ ojuju na ya irè ikpughe na enweghị oké mmetụta. Otú ọ dị, ọrịa na-agaghị adị site ọ bụla N'ihi ya, ya mere ha kpebiri inye ha mmasị ọzọ n'aka.

Ọ ga-kwuru na ndị niile na-egosi maka ojiji nke ọgwụ "Azathioprine" na-ezo aka a kama oké njọ nke ọrịa n'ihi na nke ezigbo ọgwụ nwere ike ịbụ naanị na ahụmahụ ọkachamara. Na nke a, na ikpe nke ana enyo enyo nke ọnụnọ nke ọ bụla ọrịa si n'elu ndepụta, ị ga-ata a mbara ọgwụ nnyocha, bụghị onwe-medicate.