Alkaline phosphatase - otu ihe dị mkpa enzyme ahụ mmadụ

Ka ụbọchị, mgbagwoju nchoputa nke ọtụtụ ọrịa na-eji ime nnyocha ụzọ nke nyochaa. Nke a na-agụnye a Biochemical analysis of ọbara.

Alkaline phosphatase: general e ji mara nke enzyme

Alkaline phosphatase - otu n'ime ihe ndị kasị mkpa na-egosi. Nke a compound bụ enzyme nke na-egosipụta phosphatase ọrụ. Ọ bụ ugbu a na ọ fọrọ nke nta niile mmadụ niime ụlọnga. Ya kacha ọrụ gosiri na ihe alkaline ọkara na-ejikọta ya na cell membranes. The kasị elu ịta nke a compound e dekọrọ na osteoblasts (mkpụrụ ndụ na ọkpụkpụ anụ ahụ), imeju mkpụrụ ndụ na gbasara akụrụ tubules na nsia mucosa, nakwa dị ka Plasenta. Alkaline phosphatase, nke a na ẹdude ke ọbara, dị ka a na-achị, ewepụtara ọkpụkpụ ma ọ bụ hepatocytes. Ya elu ọrụ a hụrụ isi na imeju na ọrịa na-erukwa na ihe mgbochi nke bile duct, nakwa dị ka na ọnya nke ọkpụkpụ na-ebu ọkpụkpụ remodeling.

Alkaline phosphatase larịị dị elu. N'ihi gịnị?

E nwere ọtụtụ ọrịa na-ekwu na nke ụba alkaline phosphatase. The norm nke a na-egosi na-adabere na afọ na mmekọahụ, n'ihi ya, nke a n'uche mgbe ọ na-atụgharị ọbara n'ihi mmiri ọgwụ.

N'etiti etiological ihe ndị pụrụ imetụta larịị nke enzymes, gụnyere alkaline phosphatase, kwesịrị ịgụnye ndị na-esonụ:

• ime;

• Postmenopausal;

• erighị ihe na dietary calcium, na phosphates;

• ngafe nke ascorbic acid ke idem;

• ojiji nke otu pharmacological elekọta mmadụ (e.g., gbochie afọ nwere estrogen na progesterone, nakwa dị ka ọgwụ nje).

Ke adianade do, alkaline phosphatase nwere ike ụba na-eso ọrịa:

• hyperparathyroidism;

• nkụchi obi akụrụ ma ọ bụ akpa ume anụ ahụ;

• multiple myeloma;

• na-efe efe mononucleosis;

• ọkpụkpụ ọrịa, gụnyere ọrịa cancer nke okike;

• Hodgkin ọrịa, nke pụtara na mbibi nke ọkpụkpụ;

• rickets;

• ajọ lesion nke biliary tract;

• mbufụt nke na-efe efe ọdịdị ma ọ bụ imeju nke imeju, ya meriri ụkwara nta.

Etiology belata alkaline phosphatase

E nwere ọnụ ọgụgụ nke pathologies nke, na Kama nke ahụ, alkaline phosphatase belata. N'ihi ya, na ọkwa nke enzyme n'okpuru nkịtị na hypothyroidism. Mebiri nke ọkpụkpụ ibu, erughi nke zinc na magnesium, nakwa dị ka anaemia - etiological ihe ndị pụrụ imetụta ego nke alkaline phosphatase n'ime ọbara ọbara. Inweta ụfọdụ ọgwụ nwekwara ịgbanwe ule results. Ọzọkwa, ọnụnọ nke scurvy, nke na-amalite n'ihi na insufficiency nke ascorbic acid na-eduga ná a ọnụ nke enzyme.

Ọ ga-kwuru na afọ ime alkaline phosphatase nwere ike na-eto eto site na ịba ụba ọnụ ọgụgụ nke placental isoenzyme. Nke a bụ ahụkarị nke ikpeazụ nkebi nke afọ ime na-ejikọta ya na nke kacha mmepe nke Plasenta. Ndị dị otú ahụ a ụkpụrụ nwere dịghị achọpụta ọrịa uru, n'ihi ya, ọ bụghị na ọdabara maka eleru ala nke nne ma ọ bụ nwa ebu n'afọ. N'ọnọdụ mgbe a nwaanyị na-chọpụtara placental insufficiency, ịta nke a compound na-ebelata enzyme.

Akụkụ nke mgbanwe nke larịị nke alkaline phosphatase

Alkaline phosphatase bụ n'ụdị ọtụtụ isoenzymes. Ogo abawanye na ịta nke compound na-mekọrịtara na-arụsi ọrụ ike osteoblastic (ọkpụkpụ a kpụworo usoro), nke mere na ndị kasị elu larịị nke ọkpụkpụ isoenzyme hụrụ Paget oria. Ọ bụrụ na onye ọrịa na-amalite na daa ọrịa na osteolytic ọrụ (eg, multiple myeloma), na alkaline phosphatase abawanye, ma naanị ubé.

Mgbe ọnya nke hepatobiliary usoro enwekwu hepatic isoenzyme. Na-adakarị omume, ọ na-eji dị ka a welara nke cholestasis. Na nke a, kpọmkwem ọnwụ nke imeju mkpụrụ ndụ nwere ike na-ebe megide ndabere nke nkịtị ma ọ bụ ọbụna ala etoju nke alkaline phosphatase. Ụkpụrụ a na-ahụkarị, dị ka a na-achị, n'ihi na ọtụtụ na-adakarị mgbe, ọ bụ ezie na o nwere ike ọ ga-hụrụ na onye ọrịa ọbụna na mmebi nke imeju ma ọ bụ biliary tract.

Ọ bụ uru na-arịba ama na ụba alkaline phosphatase na a na nwa - a n'ahụ onu, nke a na-ejikọta ya na ike ibu. N'ihi ya, na ọkwa nke a enzyme na ụmụaka pụrụ iru a larịị nke karịa ndị norm maka na onye toro eto mmadụ bụ 1.5-2 ugboro (site na 82 ruo 341 U / L).

Specificity ịchọpụta larịị nke alkaline phosphatase

Ka ụbọchị, na ezigbo ọnọdụ maka analysis na mkpebi siri ike nke ịta nke alkaline phosphatase bụ dị iche iche, n'ihi na onye ọ bụla laabu nwere ya na ụkpụrụ. E nwere ọtụtụ ihe nnwale ụzọ nke-adabere na enzyme mkpụrụ na echekwa usoro dị ka nke ọma dị ka okpomọkụ na nke samples na-ẹkenịmde. Edo ókè egosi "alkaline phosphatase" ọ bụghị, n'ihi ya, ọ dịghị mkpa ka e jiri ya tụnyere ụkpụrụ nke enzyme, nke e nwetara na dị iche iche laboratories. Nke a bụ eziokwu karịsịa mgbe ọ na-amaghị ihe na-achị ndị a laboratories setịpụrụ.

N'ihi analysis of ọbara ọbara na-eji. N'ọnọdụ ka ukwuu, na-ewere n'elu oyi akwa, nke na-guzobere separator tube. Ọ bụ uru na-arịba ama na larịị nke alkaline phosphatase nwere ike erroneously mụbara, ọ bụrụ na ọbara nlele tourniquet na elu N'ịdị e nyekwara iwu n'ihi na ihe karịrị 30 sekọnd. Ke adianade do, ọrụ nke a enzyme nwere ike ịdị iche ubé ma ọ bụrụ na ọbara sample e echekwara na ụlọ okpomọkụ. Na nke a na vitro hemolysis adịghị emetụta ule results.

Gịnị na-eme mgbe a enweghị nchịkwa larịị nke alkaline phosphatase?

Mgbe alkaline phosphatase mụbara, ọgwụgwọ ga nwere etiological direction. N'ihi ya, ọnụnọ nke imeju ma ọ bụ biliary ọrịa kwesịrị ịkpọ a gastroenterologist. Cholestasis, ọnụnọ pancreatitis, mmanya na ịba ọcha n'anya ma ọ bụ imeju na-achọ kwekọrọ ekwekọ mgbazi ọgwụ onye olu naanị kpebisiri ike site dibịa. Self na nke a pụrụ iduga ihe nkpasu-iwe nke onye bụ isi ọrịa.

Na-agbanwe agbanwe ịta nke enzymes, gụnyere alkaline phosphatase, nwere ike ịdị na-eme obi odida, cancer daa ọrịa na oké mmebi nke akụrụ, nakwa dị ka na-arịa ọrịa shuga, ya mere, ị kwesịrị ị na ịkpọ a cardiologist, nephrologist ma ọ bụ endocrinologist. The dọkịta ga-ekpebi ọgwụgwọ si eme dabere na-adakarị picture.

Wepụ etiological ihe, alkaline phosphatase ọrụ laghachi nkịtị. Ná nhọpụta nke ọgwụ ga-sonye na akaụntụ na ihe atụ, a n'ahụ na-abawanye nke a na-egosi bụ omume na fractures, ifịk ifịk uto nke skeletal usoro, na gestation. Ọ dịghị achọ ka ọgwụ na ahụ ike aka. Interpretation of pụta laabu ule a ga-rụrụ emejuputara, na-echebara ndị ọzọ Biochemical parameters na-enwe ndidi mkpesa.