MMF (mycophenolate mofetil): nkọwa, analogs

Mycophenolate mofetil (njem Mycophenolic acid) na-esịne ke otu nke immunosuppressants. Ka anyị tụlee ihe nkowa nke ikpe nke ọ dị mkpa na-eji ọgwụ ọjọọ, ihe bụ contraindications na ojiji na mmetụta.

Na mgbakwunye, anyị na-ahụ ma ọ bụrụ na e nwere ndị nọ n'oge a pharmacology yiri n'aka.

nchịkọta

mycophenolate mofetil dị na ụdị ike gelatin capsules na ọdụ na-acha ọcha ntụ ntụ n'ime.

Ịzụta ọgwụ ọjọọ eme ihe na pharmacies naanị ma ọ bụrụ na i nwere a ọgwụ si a dọkịta.

Adị ndụ bụ afọ abụọ pụtara. Nọgidenụ na-ọ ga-abụ na okpomọkụ ruo 25 degrees.

Iji nwere a visual nghọta nke otú anyị na-atụle anya ọgwụ (mycophenolate mofetil), foto n'elu-eje ozi ihe atụ atụ.

ọgwụ

Otu Capsule n'aka nwere 250 mg nke nọ n'ọrụ compound (mycophenolate mofetil). Ke adianade do, ugbu a na-inyeaka mmiri, dị ka croscarmellose sodium, microcrystalline cellulose, povidone na magnesium stearate.

Pharmacokinetics

Mgbe ọgwụ ọjọọ bụ ya zuru absorption na zuru ezu presystemic metabolism. Na nke a, ịta nke nọ n'ọrụ umi ke plasma a hụrụ ruru ya ngwa ngwa mgbanwe n'ime ifịk metabolites.

Pụtara anyụpụ na mmamịrị na na nsị.

egosi

Mgbe ụfọdụ, jiri nke mycophenolate mofetil? Ntuziaka maka ojiji ngwa ngwa zaa ajụjụ a.

Dọkịta maa iwu na-ewere ọgwụ maka prophylaxis nke nnukwu transplant ojuju na ọrịa mgbe akụrụ transplantation, imeju ma ọ bụ obi.

contraindications

E nwere ọtụtụ ọnọdụ ụfọdụ ebe na ojiji nke ọgwụ ọjọọ na-nditịm ajuru aju "Mycophenolate mofetil". Ndị a gụnyere ọnụnọ nke ọrịa hypersensitivity isi nọ n'ọrụ umi ma ọ bụ ndị ọzọ mmiri nke gị n'ụlọnga, nakwa dị ka n'oge ime na lactation.

The nrụpụta na nchekwa nke ọgwụ na ọgwụgwọ nke ụmụ e kwuru na ọ bụ, ya mere, na-adịghị eji ya na ọrịa ụmụaka.

mmetụta

Mycophenolate mofetil ike akpasu ụfọdụ mmetụta. Ya iji na Nchikota na cyclosporine na corticosteroids nwere ike ime ka afọ ọsịsa, vomiting, leukopenia na sepsis. N'oge ụfọdụ, e nwere mmepe nke lymphoma na ndị ọzọ na malignancies, karịsịa nke anụ.

Ke adianade do, ihe niile transplant ọrịa bụ ndị n'ihe ize ndụ nke na-efe efe, nke na-iwe na opportunistic pathogens. The kasị n'etiti ha bụ ndị herpes, candidiasis na cytomegalovirus.

Ndị ọzọ siri Jeremaya ike egosipụta onwe ha n'ụdị shingles, urinary tract-efe efe, rhinopharyngitis, hyperthermia, ndiiche imeju ọrụ, esophagitis, eriri afọ agba ọbara, na-efe efe nke elu akụkụ okuku ume na tract, ụkwara, isi ọwụwa, gastroenteritis, ike ọgwụgwụ, Sinusitis, onu candidiasis , pancreatitis, pancytopenia, neutropenia, na na.

E nwere ihe ize ndụ nke oké na ụfọdụ ọbụna dị ize ndụ phenomena dị ka ụkwara nta, nje endocarditis, gbara gharịị mycobacterial-efe efe.

Dosing na Administration

Olee otú iji ndị ọgwụ ọjọọ, "Mycophenolate mofetil"? Ntuziaka mmasị na ya, na-enye ndị na-esonụ ozi.

N'ihi mgbochi nke akụrụ jụrụ. The mbụ dose of gị n'ụlọnga ga-ẹkenam n'ime ahu n'ime 72 awa mgbe transplantation duziri. Mgbe e mesịrị, onye ọrịa ga-mkpa iji 1 g ugboro abụọ n'ụbọchị n'aka.

N'ihi ya mycophenolate mofetil na-emekarị ndinọ na Nchikota na corticosteroids na cyclosporin.

N'ihi mgbochi nke obi jụrụ. The mbụ dose kwesịrị iwere bụghị mgbe e mesịrị ka 5 ụbọchị mgbe ịwa ahụ duziri. Ekemende a dị mkpa ego nke na ngwaahịa bụ 1.5 g ugboro abụọ n'ụbọchị

ovadozu

Data na ọgwụ ovadozu, "mycophenolate mofetil," adịghị.

Ọ pụtara na ọ gaghị ekwe omume na-aghọta site ahu site hemodialysis. Ọgwụ ndị na-eke agbụ bile asịd (cholestyramine) nwere ike ikwado mwepụ nke IFC organism, ịba ụba ya excretion.

Atụmatụ nke ngwa

N'elu nchọpụta nke a ndidi neutropenia ga-belatara dose na anya nyochaa ọrịa ike okwa ma ọ bụ ịkwụsịtụ ọgwụgwọ mycophenolate mofetil.

Na ọnụnọ nke oké ala ala gbasara akụrụ odida kwesịrị anya nyochaa ọnọdụ ahụ ike nke na adịghị gafere a kacha dose n'aka, nke na nke a pụtara 2 g kwa ụbọchị.

Agadi ọrịa (afọ 65) na-atụ aro iji ihe 1 g nke ọgwụ, 2 ugboro n'ụbọchị.

Ozi banyere irè nke mmadụ na ọgwụgwọ nke ọrịa na gbasara akụrụ odida na-wara a imeju transplant ma ọ bụ obi, na-efu efu. Ọzọkwa, ọ dịghị ihe ọmụma banyere otú ọgwụ bụ irè n'ihi na ọrịa na imeju ọnya onye wara obi transplantation e mere.

precautionary jikoro

Na nke ọ bụla ike imeghe Capsule na nkwadebe. Kwesịrị izere kpọmkwem kọntaktị na ntụ ntụ: ọ inhalation, na kọntaktị na akpụkpọ ma ọ bụ mucous membranes. Ọ bụrụ na Otú ọ dị, o mere ya, kwesịrị ozugbo asa otụk ebe na ncha na mmiri.

analogues nke ego

Enwere ọgwụ ike dochie ngwaahịa "Mycophenolate mofetil"? Analogs, N'ezie, e nwere. Ha nwere otu njem (International Nonproprietary Name), ma ọ bụ ATC koodu. Ga na-abụ ubé dị iche iche ụdịdị dị iche iche nke ọrụ na ego na-akwụ ụgwọ.

The kasị ama ndị na-esonụ ọgwụ ọjọọ:

• "Baksmun". Eji na Nchikota na cyclosporine na corticosteroids maka mgbochi nke ojuju nke obi, imeju ma ọ bụ akụrụ mgbe transplantation.
• "Zenapax." Ọ na-eji gbochie ịjụ a akụrụ transplant na Nchikota na cyclosporine GCS.
• "Imusporin". Eji maka igbochi na ọgwụgwọ nke dọgharịala akụkụ na ụmị ọkpụkpụ nakwa ọrịa ogbu ogbu na nkwonkwo, endogenous uveitis, Behcet ọrịa, systemic lupus erythematosus, na ọrịa ndị ọzọ.
• "Imufet". Dị ka nke ọma dị ka isi ọgwụ, gị n'ụlọnga ndinọ na Nchikota na corticosteroids na cyclosporin maka egbochi ịjụ a dọgharịala akụrụ ma ọ bụ imeju.
• "Layfmun". Ngwá Ọrụ nwere obosara ụdịdị dị iche iche nke edinam. Ọ nwere ike na-eji maka mgbochi na ọgwụgwọ nke ịjụ dọgharịala akụkụ site na ahu na ụmị ọkpụkpụ, nakwa dị ka ogbu na nkwonkwo, nephrotic syndrome, ifịk ifịk forms of systemic lupus erythematosus, Behcet ọrịa, endogenous uveitis na ọrịa ndị ọzọ.
• "Mifenaks". Egosi maka ojiji bụ otu dị na nke isi n'aka.
• "Mifortik". Ezubere iji gbochie ojuju nke dọgharịala akụrụ.
• "Mofilet". Egosi na ojiji ndị yiri na mycophenolate mofetil.
• "Panimun". Eji na transplantation nke akpa ume, obi, akụrụ, ụmị ọkpụkpụ, pancreas, nakwa dị ka na ọrịa ụfọdụ.
• "CellCept." Ọ nwere ike na-kenyere mgbe a akụrụ transplant.
• "Sertikan". Ọ na-owụt maka akụrụ transplant ma ọ bụ obi ọrịa na-agafeghị oke ma ọ bụ ala immunological ize ndụ.
• "Tsikloral". Eji na njikọ na ndị ọzọ ọgwụ ọjọọ eme ihe na ngwa transplants.
• "Ekvoral". Ọ na-eji na transplantation nke parenchymal akụkụ, nakwa dị ka ihe mgbochi nke ojuju mgbe transplantation.

N'agbanyeghị eziokwu na ha niile nwere a yiri ụdị ihe, tupu dochie isi ọgwụ ọ bụla ọzọ, ị ga-ebu ụzọ lee, na ịkpọ dọkịta gị.