"Orgalutran": onye na-akụziri nkọwa, analogs na reviews

Na vitro njikọta - usoro bụ nnọọ mgbagwoju anya. Ọ na-enye ohere maka ọtụtụ ndị inyom na-ata ahụhụ site na infertility, na-atụrụ ime. N'oge IVF iji ọtụtụ ọgwụ ọjọọ. The kasị arụ ọrụ na nkà mmụta ọgwụ "Orgalutran." Ntuziaka ka ọ na-akọwa n'ụzọ zuru ezu na iwebata nke Usoro nke ọgwụ na adọ aka ná ntị nke na o kwere omume na ya pụta.

The mejupụtara na ụdị mmepụta

Ọ dọrọ aka ná ntị banyere mkpa ọ ịkpọ a ọkachamara n'ihu reproductologist "Orgalutran" ọgwụ ochichi ntuziaka. Product Ụdị - 0,5 ml ntụtụ na a ngwọta maka ochichi na subcutaneous injections. O nwere banyere 250 mg nke nọ n'ọrụ umi ganirelix, nke na-emepụta na ụdị acetate. N'etiti adjuvants ọrụ mannitol, ice acetic acid, distilled mmiri. Juru n'ọnụ na a kaadiboodu igbe na otu ma ọ bụ ise disposable ndụdụ na nkà mmụta ọgwụ "Orgalutran." Ntuziaka ka ọ na-abịa na-akọwa niile nuances nke ngwa nke ọgwụ.

The pharmacological mmetụta nke ọgwụ na ozu

Medicine "Orgalutran" (ọrụ na-akọwa n'ụzọ zuru ezu otú igba ọgwụ data) na-ezo aka a ihe nnabata-akụ ọkpọ nke gonadotropin-atọhapụ hormone. Ọ na-enyere soro mmepụta nke gonadotropins LH na FSH. Ọ slows secretion nke LH na FSH site pituitary gland. Ọ bụrụ na mbụ e mere mmetuta nke ndị a homonụ, na mgbochi nke secretion nke pituitary ọrụ emee fọrọ nke nta ozugbo mgbe ochichi nke ọgwụ. Nke a pụrụ isi kwuo ya na-nọgidere na-enwe ofụri ọgwụgwọ oge.

Drug ọmụmụ na nwanyi ọrụ afọ ofufo gosiri na ochichi nke ọtụtụ ọgwụ na-ebelata ịta nke 0,25 mg FSH, LH na oestradiol n'ime ọbara mgbe 74, 32 na 25 percent, karị, nke a na-enweta mgbe 4, 8 na 16 awa mgbe ogwu ogbugba. N'ihi na ụbọchị abụọ mgbe ochichi nke hormone akụrụngwa ghọrọ isi iyi.

Nke pụtara oge nke ọgwụgwọ N'ezie na kwa ochichi nke injections "Orgalutran" ke ichekwa 0,25 mg / ụbọchị soro ovulation mkpali bụ ụbọchị ise. The etiti na-abawanye na LH periodicity (n'elu 10 IU / L), Bilie na-abawanye na progesterone ọdịnaya (n'elu 1 and / ml) bụ 1.2%, nke bụ 0,8% hà GnRH agonists.

Tupu ịmalite ọgwụgwọ, "Orgalutranom" tupu ubọchi nke-isi nke mkpali ọgwụ ovarian gonadotropin agwa ndị inyom bụ ndị na-ụba ovarian Jeremaya mere aa abawanye na LH. Development of LH e-ewute ya fọrọ nke nta ozugbo mgbe mbụ ojiji na otu a nke ọrịa, "Orgalutran."

egosi

Ọ na-enye a nti utịp n'oge IVF ọgwụ "Orgalutran." Ntuziaka na-egosi maka ojiji na-atụ aro iji nke a iji ọgwụ gbochie abawanye na luteinizing hormone (LH) na ndị inyom na-eme esoro ovarian hyperstimulation iji ọzọ omumu teknụzụ.

Nke a na-agụnye na-pụrụ iche infertility usoro ọgwụgwọ na, nke na-emekarị jikọtara na recombinant follicle na-akpali akpali hormone (FSH). Na ndị a na-emetụta nanị na ndenye ọgwụ mmiri ọgwụ gị n'ụlọnga "Orgalutran." Guide nkọwa zuru ezu banyere usoro ihe omume nke ọgwụ.

contraindications

Mgbe hypersensitivity-arụsi ọrụ ike umi na inyeaka ọcha machibidoro ndinọ injections "Orgalutran" nkwadebe ntụziaka ntuziaka. The ọgwụ na-adịghị kenyere na ubara uche na gonadotropin-atọhapụ hormone na bekee analogous thereto. Òtù na ojiji nke ọgwụ ọjọọ na-ọrịa nke imeju na-na akụrụ ngwa, emi odude ke agafeghị oke ka oké nkebi nke development. Ọ dọrọ aka ná ntị na ọ na-adịghị eji n'oge ime na lactation ọgwụ "Orgalutran" ntụziaka. Contraindications ikwu banyere inadmissibility nke ọgwụ na ụmụ.

Medicine "Orgalutran": ntuziaka maka ojiji

A ọgwụ na-ikike idepụta naanị omumu usoro, na-enwe a akwa ahụmahụ. Observation nke ovarian hyperstimulation, nke a na-eduziri ndị na ojiji nke FSH, amalite na nke abụọ ma ọ bụ n'ụbọchị nke atọ nke ịhụ nsọ. Ọgwụ nke 0,25 mg enye subcutaneously ugboro kwa ụbọchị. Ha na-mere si n'ụbọchị nke isii nke eji FSH. Ọ bụrụ na e nwere onye na ụba mmetuta nke ovarian nzaghachi, iji gbochie igbu oge na-amụba index LH ọgwụ "Orgalutranom" rụrụ n'ụbọchị nke ise mgbe eji FSH ọgwụ. Ọ bụrụ na e a ngwa ngwa follicular mmepe, ọ bụ omume na-ebu iwebata "Orgalutran" ngwọta e mesịrị.

FSH ọgwụ ọjọọ na "Orgalutran" ga-eji n'otu oge. Ha apụghị-agwakọta ọnụ dị ka otu ntụtụ. Ndị a injections na-enịm ke iche iche ebe nke ahu. Ọnụọgụ ọgwụ ngwaọrụ FSH họrọ n'otu n'otu n'ihi na onye ọ bụla ndidi. On ọ na-emetụta ndị size na ọnụ ọgụgụ nke follicles na-enwe ọganihu. Ọ dịghị mkpa ka gaa na akaụntụ ọdịnaya nke estradiol ke iyịp. "Orgalutran" ndinọ ruo mgbe ruo mgbe a chọrọ ọgụgụ nke preovulatory follicles. Nweta ha ikpeazụ chaa ochichi preparations nke mmadụ chorionic gonadotropin.

Ịṅa ntị oge nke excretion nke nọ n'ọrụ umi, mara na n'agbata injections "Orgalutran" nkwadebe ga-adị ọzọ karịa 30 awa, ebe ọ bụ na nkeji n'etiti abụọ nwere ike ime n'oge ọnụ ọgụgụ kasị elu nke LH. N'ihi ya, nlekọta "Orgalutran" ụtụtụ, ọ dị mkpa ịnọgide na-data usoro ọgwụ n'elu oge ojiji nke gonadotropin. Ọ dị mkpa n'ime akaụntụ ụbọchị mgbe a bụ mmalite nke ovulation. Na iwebata "Orgalutran" na nkera nke abụọ nke ụbọchị, na-etinye ọgwụ oge ikpeazụ n'ehihie ụbọchị tupu mmalite nke ovulation.

The ọgwụ na-atụle ga kpamkpam mma ma nwere zuru ezu arụmọrụ maka ndị mmadụ n'otu n'otu bụ ndị na agbanweela ọtụtụ ọgwụgwọ cycles. Safety net ka luteal adọ nke ụkpụrụ na-eji na infertility ọgwụ.

Drug "Orgalutran" ndinọ subcutaneously naanị. Maka ọgwụ, ọ bụ na-achọsi ike ịhọrọ femoral mpaghara. Iji zere lipoatrophy, ebe ọgwụ ga-agbanwe. Ọgwụ ike ga-ndinọ naanị, ma na ọnọdụ na natara zuru ntụziaka site dọkịta. Tupu ị tinye nkwadebe, ị mkpa iji chọpụta ihe ngwọta. Ọ ga-enwe a uzo na agba na-adịghị nwere ihe ọ bụla adịghị. Ngafe ụbọchị na-ekwesịghị ekwesị nchekwa ngwaahịa ike ga-eji.

Tupu injection ga-akwọ aka na ncha na anụ ahụ, n'ihi na ewebata ntụtụ, ọ dị mkpa iji hazie ihe mmanya. The-echebe okpu ga-ewepụ agịga. The akpụkpọ ga-clamped na anọghị n'ogige atụrụ n'etiti mkpịsị aka na forefinger, na agịga na-positioned na n'akuku nke 45 ° C na ya elu. Iji nyochaa na ọnọdụ nke agịga, mkpa a obere esiri na plunger na-ahụ, adịghị na na ntụtụ ọbara. Ọdịdị ahụ ya na-egosi penetration nke agịga n'ime ọbara arịa. Na nke a, ọgwụ ndinọ ajuru aju. Ọ kwesịrị ịchịkwa na agịga na ntụtụ na itinye na ọgwụ mpaghara swab gwara n'ụba mmanya maka a nkeji ole na ole. Na-etinye ọgwụ ọ bụla a ọhụrụ ntụtụ. Ọ bụrụ na agịga na-positioned n'ụzọ ziri ezi, na a ngwa ngwa nwayọọ nwayọọ na-na otu mgbalị kwesịrị itinye nsogbu na pistin. Nke a na usoro nke ochichi emeghị ka akpụkpọ mebiri.

Mgbe ọgwụ agịga ngwa ngwa wepụrụ na etinyere na-agbanye mpaghara ihe mmanya swab. Ntụtụ naanị otu ugboro nwere ike ji mee. Ọ bụrụ na ọgwụ ọgwụ oge Agbaghara, ọ ga-enweta a shot ka anya dị ka nwaanyị na-eche banyere ya. I nwere ike ịbanye a abụọ onunu ogwu nke ọgwụ iji chefuo a Agbaghara ogwu ogbugba. Ọ bụrụ na ndị na-egbu oge na iwebata ọgwụ bụ karịa awa isii, na oge n'etiti injections - ihe karịrị iri atọ awa ahụ, onye ọrịa na ohere ọ bụla ga na-abanye ọgwụ ọjọọ na-achọ ndụmọdụ site n'aka dọkịta.

mmetụta

Ọ dọrọ aka ná ntị na e nwere ike ịbụ oghom Jeremaya mere na ọgwụ site, "Orgalutran" nkwadebe ntụziaka (foto nke ọgwụ ị pụrụ ịhụ n'elu). Dị ka a na-achị, ọ bụ nācha ọbara-ọbara, ọzịza na itching. Oghom Jeremaya mere nwalere otu awa mgbe ogwu ogbugba. Site n'oge ruo n'oge e nwere a n'ozuzu adịghị ike, ihe ọkụ ọkụ na akpụkpọ, ọzịza nke ihu na ihe isi ike na ume. Ka njọ ọnọdụ dị ka eczema, akpata isi ọwụwa, ọgbụgbọ. Ụfọdụ ndị na-adịghị mma mgbaàmà jikọtara gonadotropin ọgwụ, nke a na ẹkenịmde ke ovarian hyperstimulation. A, nke a mgbu na pelvic ebe, ectopic ime, abdominal distention, ovarian hyperstimulation syndrome.

adọ aka ná ntị

Women na-predisposed ka allergies, i kwesịrị ịkpachara anya mgbe ị na-eji "Orgalutran" ọgwụ ọjọọ. Ntuziaka na nkọwa nke nkwadebe adọ aka ná ntị na hypersensitivity ka Efrata backlash gosiri ozugbo mgbe mbụ ogwu ogbugba. Drug nkwakọ emi esịnede roba latex, pụrụ ịkpasu adịghị anabata.

Iji ọgwụ ọjọọ eme ihe "Orgalutran" na-emekarị na-aga n'ihu ruo mgbe a chọrọ ọgụgụ nke preovulatory follicles. Ha ikpeazụ maturation na-enweta site n'iji mmadụ chorionic gonadotropin. Ịṅa ntị na ọkara ndụ-nke nọ n'ọrụ umi, anyị mara na n'agbata ochichi nke ọgwụ ekwesịghị ịbụ ihe karịrị 30 awa. Nke a ọnọdụ gbasara ngalaba-nlekọta "Orgalutran" na injections nke HCG. Ọ bụrụ na ị na-adịghị eme ihe kwekọrọ na nke a na-achị, ndị LH elu nwere ike ime nká. Iji injections "Orgalutran" ụtụtụ, ọ ga-aka iso ruo ụbọchị HCG ochichi, gụnyere ya. Mgbe mgbede ochichi nke ọgwụ dose mee n'abalị ikpeazụ tupu ụbọchị na tupu ngwa nke HCG.

Ugboro ugboro aṅụ ọgwụ na-na-rụrụ mgbe ihe ntule nke irè nke ọgwụgwọ na ike n'ihe ize ndụ. N'oge ovulation mkpali mgbe ụfọdụ na-egosi ovarian hyperstimulation syndrome. Ekwe omume nke ọrịa a ga-atụle mgbe nile n'okpuru ọgwụgwọ na gonadotropins. Ọ bụrụ na ndị ovarian hyperstimulation syndrome na-gosi na-agafeghị oke na oké nkebi nke mmepe, na-kpụ ọkụ n'ọnụ ọgwụgwọ a na etinyere iwebata n'ime akwara na colloidal electrolyte ngwọta, nakwa dị ka heparin. Nke a ọgwụ a rụrụ n'elu ọtụtụ ụbọchị.

The ọgwụ bụ nchebe iji, pụtara ìhè site na ọtụtụ preclinical ọnwụnwa na-elekwasị anya na-amụ genotoxicity na toxicity. Teratogenic dị ka nkà mmụta ọgwụ na-adịghị egosi. The irè dị ka obi iru ala ochichi nke agwọ ọrịa, ka e guzobere na ndị inyom na-enwe a ibu uku 90 n'arọ, ma ọ bụ ihe na-erughị 50 n'arọ.

The puru of congenital malformations na nwa ebu n'afọ mgbe eji aka omumu teknụzụ bụghị nnọọ elu karịa na mbụ tụụrụ ime nke nwa. Ọ bụrụ na e nwere malformations, ọtụtụ mgbe ha na-adabere na onye e ji mara nke nne na nna. Ozugbo Art bụ mgbe a n'ihe ize ndụ nke a multiple ime. A kpọmkwem njikọ n'etiti puru nke omume nke ntụpọ na ojiji nke GnRH akụ ọkpọ na-enweghị.

Ọ dị mkpa na vitro njikọta spam na a-adọ ha n'ụzọ na-ebu ihe ultrasound ule, dị ka ndị inyom na Tubal daa ọrịa ize ndụ nke ectopic ime bụ nnukwu iji. Ọ dọrọ aka ná ntị na i nwere ike iji mgbe Mmebi ụbọchị nke bụ afọ abụọ, ọgwụ "Orgalutran" ntụziaka. Nchekwa nke ọgwụ kwesịrị ịbụ na a akọrọ, ya ndò si anyanwụ na nke iru nke ụmụ. The okpomọkụ nke ihe ngwọta nchekwa mode maka injections malite site 2 na 30 Celsius C.

eri nke

Ọ bụghị ọ bụla ahịa ọgwụ pụrụ ịchọta ọgwụ "Orgalutran." Ntuziaka na nkọwa ọgwụ adọ aka ná ntị na ọgwụ bụ ike hormone, ya mere ẹkesiode pharmacies nditịm na ndenye ọgwụ. The nkezi price kwa mkpọ ise vials hovering gburugburu 6000-7000 rubles. Otu mkpọ efu banyere 1700-2200 rubles.

analogs

Na-ekwu na mgbe mmetụta apụta iji kagbuo iji "Orgalutran" nkwadebe ntuziaka. Analogs nwere ike dochie ya, ma ha ga-họọrọ naanị site a dibịa ma ọ bụrụ na ọ dị mkpa. Na nkà mmụta ọgwụ, e nwere naanị otu analogue - bụ "Tsetrotid". The na-eri nke onye ntụtụ bụ 1200 rubles, asaa - 8500-10000 rubles. Mepụta a dochie anya na Switzerland.

nleba

Ọ na-egosi na aka ime n'oge IVF ọgwụ "Orgalutran" ntụziaka. Nyocha na-ekwu na nkà mmụta ọgwụ arụ ọrụ dị ukwuu na ewepu mmepụta usoro nke egg follicles. The agwọ ọrịa na-packaged ke nditịm kọwaa doses, o nwere a mkpa agịga, na-eme a shot na-fọrọ nke nta ka ọ bụghị obi, na usoro maka ochichi na-akwụ ụgwọ na-enweghị ozizi na ichihịa, ma na ọnọdụ na e mere ihe n'ụzọ kwesịrị ekwesị, dị ka ntụziaka.

Otu n'ime ihe ndị na-ezighị ezi akụkụ nke ọrịa mgbu mgbe ọgwụ na saịtị. Adịghị m obi ụtọ ma na eziokwu ahụ bụ na ọgwụ ọjọọ na-esi ike ịzụta na a mgbe nile na-ere ọgwụ, na ọtụtụ ndị inyom na-enye ịzụta ụlọọgwụ. Ụfọdụ na-injections mere a ọnụ ke agụụ. Kasị ghara inwe afọ ojuju na elu price nke ọgwụ, ma ha na-ekwu na ọ bụ ọnụ ahịa ya.