"Torasemide": ntuziaka maka ojiji. "Sandoz Torasemide": price, ọnọdụ, reviews

"Torasemide" - a oge a dị ike mamịrị ọgwụ na zuru okè n'ihi na ogologo oge ọgwụ ọrịa metụtara na ọdịdị edema. N'ihi na nta ọtụtụ clinically mkpa mmetụta, obosara ya ọgwụgwọ ojiji ọzọ. Ọ bụ odi mfe na ndị ọzọ loop diuretics na nwere ihe àmà na-egosi. Na ọgwụgwọ nke ọrịa dị iche iche na onunu ogwu gbanwetụrụ. Ọzọkwa, ọ bụ na ọdabara na ikpe nke na insufficiency nke akụrụ ọrụ ọbụna na a ala filtration ike ọsọ glomeruli nephrons.

Mmetụta "torasemide"

"Torasemide" dị ka onye nnọchiteanya loop (nnu) otu diuretics eme na luminal akụkụ nke epithelium nke tubules nke nephron na-arịgo òkè nke akaghị nke Henle. Agbalịsi ihe inhibitory utịp ke nkwonkwo iga nke potassium ion na sodium chloride, ọ budata ebelata electrochemical nwere na n'elu epithelium nke nephron. Mgbochi N'ihi bụ nsogbu nke ion iga sodium reabsorption si isi mmamịrị, nke enwekwu diuresis.

Fọrọ nke nta niile loop diuretics ime ka electrolyte disturbances n'ihi na ike mmetụta reabsorption nke potassium ion, sodium, magnesium na chlorine. "Torasemide" ka a nta ruo n'ókè-emetụta nhọrọ nke potassium na magnesium, n'ihi na nke a ukwuu ala omume nke arrhythmias, anorexia, afọ ntachi, muscle adịghị ike. Ọzọkwa, ọgwụ ka a nta ruo n'ókè nkanka guzobere thromboxane A2, inyịme arịa. Ọ na-nkanka aldosterone anabata infarction, inhibiting Filiks nke fibrosis nke obi muscle.

na-agba akaebe

Mmasị ka ọgwụ ọjọọ, "Torasemide" ntụziaka ntuziaka e dere ozi banyere ọrịa ya, nke o ji mee ihe maka ọgwụgwọ. "Torasemide" gosiri maka:

• pathogenetic ọgwụgwọ nke ọbara mgbali elu eguzogide ọgwụ na n'ịgwa nke Ace inhibitors (ARBs) thiazide diuretics;
• ọgwụgwọ nke ala ala obi odida, metụtara a ọbara bufee okirikiri;
• symptomatic ọgwụgwọ nke ala ala gbasara akụrụ odida, gụnyere nzacha na ala ọsọ (erughị 20 ml \ min);
• symptomatic ọgwụgwọ nke imeju (na metụtara hypoalbuminemia) edema dị ka onye ọzọ "Furosemide".

Mgbe ọbara mgbali "Torasemide" analogues na generics na-eji nanị mgbe ọdịda nke thiazide diuretics. A ọgwụ nwere ike ndinọ bụ ogologo n'ihi obere ọnụ ọgụgụ nke clinically mkpa ma dị ize ndụ mmetụta na gbasara akụrụ odida. Ndị nke "torasemide" bụ ihe na-erughị ka nke "Furosemide".

Ntuziaka maka ojiji

Dabere na -adakarị ụkpụrụ nduzi maka ọgwụ "Torasemide" ntụziaka ntuziaka mejupụtara ndị e ji mara ọgwụ Dosages chọrọ maka ọgwụgwọ na mgbazi nke lekwasịrị ọrịa. Ebe ọgwụ onwe ya dị na mbadamba nwere ndị na-esonụ Efrata: 2,5 mg, 5 mg, 10 mg, 20 mg, 50 mg, 100 mg, 200 mg.

Iji ọgwụ ọjọọ na a mbadamba nke ụtụtụ, n'agbanyeghị nke nri. N'ihi na ndị a doses nke ọgwụ "Torasemide" price dị iche iche: ọ bụ ala na nke kacha nta dose na kasị elu na kacha. Dị ka nkezi data, 30 mbadamba nke ọgwụ na 5 mg bụ banyere 400 rubles. Mgbe anata a dose na-ekesa dị ka ndị a dị ka ndị na-egosi:

• na ọgwụgwọ nke ọbara mgbali e 2,5 - 10 mg / ụbọchị;
• natara 10-20 mg / ụbọchị maka ala ala obi odida;
• adịghị ala ala gbasara akụrụ odida - 50 mg ma ọ bụ karịa;
• mmebi imeju na-achọ onye dose mgbanwe.

Mmetụta "torasemide"

Mmasị ka ọgwụ ọjọọ, "Torasemide" ntụziaka ntuziaka e dere ozi banyere multiple mmetụta. Mgbe ọgwụgwọ dose, ntụgharị ruo 200 mg kwa ụbọchị enwekwu ihe ize ndụ nke thromboembolic nsogbu, gbasara obi ischemia, ọrịa ụbụrụ. Ọ na-enwekwu ihe ize ndụ nke na-akwụsị akwụsị ischemic ọgụ na myocardial infarction, akpa ume embolism, arrhythmias. E nwekwara a puru nke omume nke nfụkasị rashes ma ọ bụ aṅụ mgbe onye ọrịa pụrụ ịrịa.

"Torasemide" mgbe ụfọdụ na-akpata ọgbụgbọ ma ọ bụ vomiting, adịkarịghị ikpeziri dyspepsia, afọ ọsịsa. Kọwara dịpụrụ adịpụ ikpe nke pancreatitis n'oge ọgwụgwọ na "torasemide". Nwekwara ụba hepatic transaminases, na-egosi imeju toxicity nke ọgwụ na elu doses. Mgbe ụfọdụ, ọrịa na-nchegbu banyere ịkụ na nti, bịara ikiri ọhụụ.

Mgbe ị na-enweta a na-egbu egbu dose na-emepe emepe obodo nke ovadozu na obere ihe mgbaàmà. Ovadozu na-esonyere a ọnwụ nke ọmụmụ na mmamịrị: diuresis ogologo na Ugboro, nwere ike ịzụlite hypotension, vaskụla ida, na-ada mbà, ọrịa strok, ọrịa ụbụrụ ischemia na ndabere.

Contraindications na-agaghị emeli nke ngwa

Drug "Torasemide" analogues na ọnyà ọgwụ ọjọọ nwere ike ọ gaghị eji na ọnụnọ nke zuru contraindications. Ndị a bụ ndị anabata ọgwụ ma ọ bụ binders. "Torasemide" machibidoro iwu iji na gbasara akụrụ odida na anuria, imeju ọdịda mgbe na a steeti hepatic Coma, na tachyarrhythmias. Contraindicated oriri n'oge lactation na afọ ime, nakwa dị ka n'okpuru afọ 18 afọ, hypersensitivity ka sulfonamides.

Akụkụ na jikọtara mmetụta "torasemide"

Na ọgwụgwọ nke ọbara mgbali mkpụrụ ọgwụ "Torasemide" nwere ike inwe mmetụta ọjọọ n'ahụ na N'ezie nke gout. Ebe ọ bụ na proximal tubules nke nephron ifịk umi ingested site n'ọrụ iga, e nwere mpi mgbochi nke excretion nke uric acid. Against ndabere nke eji "torasemide" elu puru nke hyperuricemia na nnukwu gout.

Agwọ ọrịa "Torasemide" e ji a kpọmkwem ihe na proximal òkè nke tubular epithelium akaghị nke Henle. N'ihi na ike mamịrị mmetụta na electrolyte ahaghị nhata a na-eme ka ohere clinically mkpa pharmacological interactions. Ha dị ize ndụ, na-abaghị na-achọsi ike. Otu n'ime ihe ndị dị ize ndụ na mkpa bụ:

• elu dose (50 mg / ụbọchị) "torasemide" mgbe eji na njikọ na platinum preparations enhances toxicity nke ikpeazụ;
• nnukwu doses "torasemide" (50 mg / ụbọchị) dịkwuo nephrotoxic na ototoxic mmetụta nke aminoglycoside ọgwụ nje;
• na cephalosporin ọgwụ nje, mgbe eji na "torasemide" na a dose nke 50 mg / ụbọchị na-egosi ihe onwunwe nephrotoxicity;
• salicylates na "torasemide" (50 mg / ụbọchị) ji neurotoxicity.
• "Torasemide" megide ndabere nke a ikwu hypokalemia enwekwu susceptibility nke myocardium na gbasara obi glycosides, na-amụba ha inotropic na antiarrhythmic mmetụta, na-amụba ihe ize ndụ nke toxicity;
• ihe ize ndụ nke hypokalemia na-amụba site concomitant eji "torasemide" na corticosteroids ma ọ bụ saline laxatives;
• "Torasemide" enhances mmetụta nke "theophylline" curariform na muscle relaxants.

Chọrọ mmetụta nke jikọrọ ojiji

Nke chọrọ mmetụta nke na-achọ nlekota oru, bụ a ọnụ ke ọbara mgbali n'oge ọgwụgwọ na Ace inhibitors. "Torasemide" n'ihi na mwepụ nke ọmụmụ na-ebelata ihe hydrostatic mgbali nke ọbara ka onye ogbugbo n'etiti a dobe na ọbara mgbali. Akụkụ a bụ ihe dị mkpa na ọgwụgwọ nke ọbara mgbali na-achọ mgbazi nke dose of Ace inhibitors. Ọzọkwa, na ọgwụgwọ nke ọrịa na-eguzogide ọbara mgbali na a Nchikota ihe Ace inhibitor "torasemide" enye ohere ka anyị nweta ihe normalisation nke ọbara mgbali na 90% nke ọrịa.

Na ọgwụgwọ nke ala ala obi odida bụ clinically mkpa mmetụta nke mbenata vasoconstrictor ọrụ nke catecholamines. Heart na a ndabere mamịrị ọgwụ "torasemide" ọgwụgwụ ihe mee na stimulatory n'ókè adrenaline na noradrenaline. Otú ọ dị, otu mmetụta nke mbenata irè nke epinephrine na nọrepinefrini n'oge iji tụtee mmadụ.

Mmetụta ọjọọ nke na mmekọrịta

E mmetụta mgbochi nrụpụta mgbe jikọtara na ụfọdụ bekee. Akpan akpan:

• preparations nke bile acid sequestrants belata kpọọ "torasemide" nke bowel, ebelata mmetụta nke ikpeazụ;
• narcotic analgesics (NSAIDS) belata irè nke "torasemide";
• "Probenecid" n'ihi amplification Filiks urikozuricheskih egbochi nhọrọ "torasemide" na lumen nke tubules, mbenata ya irè.

Comparative e ji mara "torasemide"

Na nkwadebe "Torasemide" analogs nwere ike ịbụ na klas, kinetic na generics. Otu n'ime ihe ndị na klas na-anọchi anya analogues: "Furosemide", "bumetanide," "ethacrynic acid". Tụnyere "Furosemide" "Torasemide" e ji a ngwa ngwa mmalite nke edinam na a ọzọ ruo ogologo oge mmetụta mekọrịtara na ụba diuresis. Inye mamịrị mmetụta dị fọrọ nke nta ahụ ike dị ka nke "Furosemide" "Torasemide" nwere ole na ole mmetụta jikọtara ngwa electrolyte ahaghị nhata.

"Bumetanide" e ji ọbụna ike mamịrị onwunwe na-ejikọta ya na ọtụtụ mmetụta. Ethacrynic acid nwere ala mmalite ọnụego mamịrị mmetụta na-adịkarịghị eji ọgwụ. The pharmacokinetics nke ọgwụ "Torasemide" reviews ọkachamara na-aghọta ihe ọzọ dị mkpa mgbe. The ọgwụ nwere Njirimara nke "rebound": diuresis mgbe amplification site n'iwepụta sodium dịghị compensatory ya njigide.

Pharmacokinetic analogues "torasemide"

The "Torasemide" ọgwụ ndu enye ihe ọmụma na ya ngwa na ọrịa na ọbara mgbali elu. Yana ọgwụ, maka ọgwụgwọ nke ọbara mgbali na na-eji thiazide diuretics, potassium-agabiga. Na thiazide ruru nwayọọ nwayọọ na-abịa ma na ruo ogologo oge mamịrị mmetụta bụ ọgwụ ọjọọ nke oke.

Na njikọ na ndị a pharmacokinetic atụmatụ analogues maka nkwadebe "Torasemide" ngwa nwere ike ịbụ ndị na-esonụ: ọgwụgwọ nke ọbara mgbali elu, na-eguzogide ọgwụ ọkọlọtọ ọgwụ na Ace inhibitor n'ịgwa (ma ọ bụ angiotensin ihe nnabata blocker) na a thiazide. Ọzọkwa, "Torasemide" na-eji na-adịghị ala ala gbasara akụrụ odida ọgwụgwọ na belatara filtration ikike.

Generics "torasemide"

Na nkwadebe "Torasemide" ntụziaka ntuziaka, analogues, na-egosi na contraindications n'ụzọ zuru ezu mara na isi mmetụta - ụba diuresis. Ọzọkwa, dị otú ahụ edinam nwere na mbụ ọgwụ ọjọọ na ọnyà. Nke ikpeazụ nwere otu ọnụ ọgụgụ nke "torasemide", ma na-emepụta n'okpuru ọzọ ika aha.

The kasị ama bụ: "Britomar", "Diuver", "Sandoz Torasemide", "Trifas", "Torcida", "Trigrim". N'oge ọtụtụ ule nke pharmacological mmadụ ịrịba iche na-hụrụ n'etiti ha na Russia. Onye ọ bụla nke n'elu formulations n'ụzọ zuru ezu na-anọchi onye nke ọzọ nke ha.

Economic akụkụ nke ọgwụgwọ "torasemide"

Na ọgwụgwọ nke ọbara mgbali mgbe thiazide diuretics bụ adighi ike na Nchikota na Ace inhibitors (ma ọ bụ ARBs), nwere ike ndinọ ọgwụ ọgwụgwọ "Torasemide": ntuziaka maka ojiji rụrụ ụka otu dose n'ụbọchị. Kwa ọnwa, na-eri nke ọgwụgwọ bụ banyere 400 rubles na price nke 60 mbadamba ọgwụ banyere 760-800 rubles. N'ihi na ha tụnyere, kwa ọnwa, price nke ọgwụgwọ "Furosemide" adịkarịghị gafere 20 rubles. Ma nke abụọ maka na-aga n'ihu ọgwụgwọ nke ọbara mgbali bụ nke obere uru.

Na-adịghị ala ala obi odida na edema nke ma okirikiri mgbasa eri nke ọnwa ọgwụgwọ "Furosemide" bụ ihe 20-30 rubles. Na nkwadebe "Torasemide" price bụ 10-15 ugboro ukwuu. Nke ikpeazụ nwere a nwayọọ mmetụta, na bụ keabaghi uru enwekwu excretion nke mmamịrị ke akpa awa nke n'ikuku. The "Furosemide" e ji mara nke agbara: ọ na-eme nnọọ na ego nke mmamịrị ke akpa awa abụọ na a nwayọọ nwayọọ na-agwụ ike nke mmamịrị mmepụta.

N'ihi ya, aru ọrịa na ọbara mgbali ma ọ bụ ala ala gbasara akụrụ insufficiency ma ọ bụ ọbara ezi uche eme "Torasemide" ntụziaka (ya price gosiri n'elu) na ngwa nke nwere ihe ọmụma banyere ihe ịrịba nkwalite nke diuresis ke akpa oge nke n'ikuku. Otú ọ dị, ezumike nká afọ nke ọrịa na-anọghị nke mkpa na-abịa na-arụ ọrụ, mmamịrị mmepụta ọsọ bụ fọrọ nke nta na-adịghị mkpa. Ọ na-adịghị ike isi ike, ya mere na-enye ohere ị na-enweta a ọnụ ala klas analogue - "Furosemide".