Anti-TPO - a mwute ule maka nchoputa nke autoimmune thyroiditis

Yana ọrịa nke obi usoro na-aga n'ihu ibu na endocrine ọrịa - ọrịa shuga na thyroid ọnya nke iche iche iche iche.

Otu n'ime ihe ndị ikpeazụ enyene a pụrụ iche n'ebe hypothyroidism, ebe ọdịdị ya na nwata na-akpata a oké ụkọ nke uche na nke anụ mmepe nke nwa. Ọtụtụ mgbe, a na-akpọ autoimmune thyroiditis ma ọ bụ Hashimoto si. Na ọrịa a nwere ike ime na atọ na-adakarị iche-iche. Nke a hypertrophic, na nke a compensatory hyperplasia nke thyroid gland, atrophic, na-emepe emepe nke abụọ ogbo nke ọrịa na e ji dochie anya nkịtị connective anụ ahụ Ọdịdị, na alopecia na nke lesion ekpuchi naanị otu òkè ahu.

uru analysis

Ọtụtụ mgbe, naanị ezi ihe àmà nke ọrịa bụ ọbara nchọpụta nke mgbochi TPO, i.e. -alụso ọrịa ọgụ megide thyroid peroxidase - isi enzyme guzobere triiodothyronine na thyroxine.

N'ihi na ha na-arụ ọrụ na-akwusila iodination nke thyroglobulin, thyroid bughi protein na nkanka n'ihu njikọ nkebi nke ya homonụ. Ebe ọ bụ na nke a bụ ihe kasị enwe mmetụta ọsọ ọsọ ule na nchoputa nke Hashimoto si goiter, mgbe ahụ, dọkịta-enyo enyo nke nwere ọrịa na-kenyere a mmiri ọgwụ ọbara ule. Anti-TPO na ikpe nke a mma n'ihi ga-amụba, na mgbe nchoputa kpamkpam gosipụtara. Naanị na nke a, ndị dọkịta ga-enwe nri ka nwere ike ikwu ihe kwesịrị ekwesị ọgwụgwọ na-enye a mma prognosis n'ihi ọrịa. Mkpa karịsịa bụ ule ka nwanyị dị ime, t. Iji., Ọ bụrụ na ha na-egosi elu mgbochi TPO, ọ na-ekwu banyere oké ihe ize ndụ nke na-emepe emepe ọbara thyroiditis na pernicious mmetụta nke ọrịa na nke nwa ebu n'afọ. Larịị nke ndị a-alụso ọrịa ọgụ bụ ejikari 0-5,6 IU kwa milliliter nke ọbara, na a ọnụ pụrụ hụrụ na ndị ahụ siri ike n'okpuru afọ 50 afọ. Ma mma (mgbochi TPO n'elu nkịtị) ule nwere ike ịbụ na ọrịa ndị ọzọ nke thyroid gland, otú ahụ nchoputa nke a pathologies ga-eme bụchaghị mgbagwoju, ọnụ na ihe analysis na T3, T4 na TSH.

mgbagwoju research

Hashimoto ọrịa na-adị mgbe a ọdịda ke dịghịzi usoro, ya bụ, mgbe ọ bụ oké mmasị ma ọ mbenata T-suppressor ọrụ. Ya mere (tinyere mgbochi TPO), n'ime ọbara nke ọrịa na-hụrụ ndị ọzọ-alụso ọrịa ọgụ: Ọdịdị ka thyroid (thyroglobulin microsomal nta) na ndị ọzọ na akụkụ kpamkpam. Nke a na-eme ka ya mix na ndị ọzọ, ọ bụghị endocrine, pathologies nke autoimmune malite. Ke adianade ule maka mgbochi TPO na homonụ, dị mkpa ngwá ọrụ nkwenye goiter Hashimoto. N'ihi ya, n'oge ihe ultrasound nnyocha nke thyroid gland nwere ike na-egosi heterogeneity nke ya Ọdịdị, hypoechogenicity ụfọdụ ngalaba, ọnụnọ nke calcification na ndim nke Capsule. More siri ike prognosis aghọ n'ọnọdụ ndị ahụ ebe ngwa ga-ọnụ dị ka ihe 5% nke ikpe ha ozlokachestvlyayutsya.