Creatinine - na-ahụkarị n'ime ọbara na mmamịrị. The adakarị pụtara sample

Creatinine - onye ọtùtù nke ọbara onwu na urinalysis. Na-adakarị onwu ọ na-ekpebisi tumadi site nchoputa reabsorbtsionnoy filtration na gbasara akụrụ ọrụ. Maka dibịa, creatinine, ọnụego na-abawanye na ya ma ọ bụ enweghị nchịkwa na-ekwu mpịakọta. Ma ka anyị buru ụzọ tụlee ihe a umi bụ na otú ọ na-emepụta ke idem.

Of n'ihi mmiri ọgwụ akwụkwọ ọgụgụ pụrụ ịchọta na creatinine bụ otu n'ime ndị na-akpọ end-ngwaahịa nke metabolism. Ọ a kpụrụ si a protein creatine eje ozi ike isi n'ihi uru. Na muscle creatine bụ a compound nke a na-akpọ phosphocreatine. Na Mbelata muscle creatine enye ya ume, na ọ etịbede ala ikpeazụ ngwaahịa - creatinine, mmiri na site ọtùtù. Ya mere na ahụ na-egosi creatinine. Ya ịta na-adabere na ego nke muscle uka. N'ihi nke a, ọbara creatinine ikom, ọnụego ya, mgbe elu karịa nke ụmụ nwanyị.

Ọgwụgwụ ngwaahịa nke usoro nke protein metabolism anyụpụ site na akụrụ na mmamịrị. The glomerulus creatinine n'ebe ọbara na-ẹdụk na-ebe n'ime ndị gbasara akụrụ tubules. N'oge kwesịrị ime ihe akụrụ na-kpam kpam wepụrụ si ahụ, ya bụ, ọ na-ekpocha si ọbara. On a dabeere ya atụmatụ otu n'ime ndị kasị mkpa ule nke akụrụ - ịlele Rehberg. Iji ya kpebisiri ike glomerular filtration. Na na ndabere nke mara GFR gbakọọ gbasara akụrụ tubular reabsorption. Ma ka okwu banyere nke a mgbe e mesịrị.

Creatinine onye norm maka ndị ikom bụ 0,044-0,106 mmol / l, na n'ihi na ndị inyom - 0.44-0,88 mmol / L abawanye isi na akụrụ ọrịa. A ọnụ ọgụgụ nke laboratories nchoputa na-owụt ke ọzọ nkeji - na micromoles. Itinye na micromoles mmol creatinine ọgụgụ ga-uba site 1000. Dị ka ihe atụ, ọnụego n'ihi na ndị ikom - 44-106 mmol / l.

Mụbara creatinine - otu n'ime ndị isi mgbaàmà nke akụrụ odida. Ọ bụ n'ihi na eziokwu na filtration na gbasara akụrụ glomeruli mbelata n'ụzọ dị ịrịba ama mgbe gbasara akụrụ ọnya.

Otú ọ dị, gbasara akụrụ daa ọrịa - bụghị nanị ihe mere na-abawanye nke a na-egosi. All na-ekwu na ọrịa bụ nke a ngwa ngwa mmebi nke phosphocreatine na uru, nwekwara ike dịkwuo creatinine n'ime ọbara elu nọmba. Nke a nwere ike sikwuo ike muscular ọrụ, hyperthyroidism, oriri ọgaranya protein, akpịrị ịkpọ nkụ, acromegaly.

Mgbe ọnọdụ ndị metụtara muscle anụ ahụ ọnya, creatinine ụba, kwa. Ka ihe atụ, ọtụtụ myocardial infarction esonyere ụba creatinine. Radieshon ọrịa, Burns, anwụrụ syndrome nwekwara n'ihu na-ọmume-ya.

Inweta ụfọdụ ọgwụ enwekwu creatinine. Ya norm nwere ike karịa ma ọ bụrụ na onye ọrịa na-enweta sulfonamides, barbiturates, ọgwụ nje nke tetracycline na aminoglycoside usoro.

The ọnụ ke creatinine ala karịa nkịtị adịghị nwere na-achọpụta ọrịa uru, dị ka onye na-abawanye. O nwere ike ịbụ n'ihi na ha erughị eru oriri nke protein oriri, agụụ, ike ọgwụgwụ. Mgbada n'usoro creatinine ke akpa atọ nke afọ ime, edema, ascites. Ọ na-enyere belata creatinine ruo ogologo oge iji corticosteroids.

N'ihi na-enyo enyo na gbasara akụrụ odida, dị ka na-ama kwuru, ọ na-emekarị ndinọ Reberga sample.

Mgbe ọ na-kpebisiri ike site na-eduzi creatinine, ọnụego nke n'ime ọbara nke gbasara akụrụ odida nwere ike nke ukwu karịa na mmamịrị creatinine. Mmamịrị sample Rehberg ga-anakọtara n'ụbọchị, ọ na-enye ihe ezi pụta karịa ma ọ bụrụ na ọ na-anakọtara na obere oge. Ọ dị mkpa n'ụzọ ziri ezi tụọ ya olu. The laabu na-anapụta a obere ego nke kwa ụbọchị mmamịrị olu, ihe niile ọ na-adịghị ga-ibu. Mgbe obon mmamịrị kwesịrị izere ikike mmega ahụ na-eri nke ukwuu protein. Blood ga na ihe efu afo nke ụtụtụ. The kwa creatinine excretion na mmamịrị na nkịtị hà 4,4-17,7 mmol / ụbọchị.

Mgbe na-ekpebi ọbara na mmamịrị creatinine, ebe ọ maara na ego nke kwa ụbọchị mmamịrị, ọrịa na-arọ na ịdị elu (na nke ikpeazụ na-emetụta ukwuu n'ime ụmụaka) na a pụrụ iche laabu usoro wepụtara na glomerular filtration wee - tubular reabsorption. Standards maka n'etiti-agadi okenye na: glomerular filtration maka ndị ikom - 82-140 ml / min, nwanyi - 81-128 ml / min. Norma tubular reabsorption - 95-99%. Bụrụ na nke mebiri gbasara akụrụ ọrụ, ndị a ụkpụrụ na-ebelata.