"Korvitol": analogues, reviews, ntuziaka maka ojiji. Gịnị nwere ike dochie anya "Korvitol 50" na "100 Korvitol"?

Ọrịa obi bụ kasị. Iji ngwa ngwa belata nsogbu, belata obi ọnụego, belata ọnọdụ nke rịaworo pectoris, migraine, ọgwụ na-ewere "Korvitol". Analogs họpụtakwara mgbe n'ihi otu ihe ma ọ bụ ọzọ. The ọgwụ nwere contraindications, ya mere tupu ojiji, ịkpọ gị dọkịta.

Hapụ ụdị na mejupụtara nke ọgwụ

The ọgwụ bụ beta-blocker. Ọ na-emepụta na ụdị ọcha mbadamba nke nwere a okirikiri spigot, na otu kwadoro chamfer ize ndụ. Dị na abụọ Dosages:

• "Korvitol 100". O nwere 100 mg nke nọ n'ọrụ mgwa metoprolol tartrate.
• "Korvitol 50". Ọ nwere a mejupụtara nke 50 mg nke nọ n'ọrụ mgwa metoprolol tartrate.

Ọzọ Efrata ma iche nke otu nke na adade lactose monohydrate, magnesium stearate, povidone K30, croscarmellose sodium, sịlịkọn dioxide, colloidal talc.

The mbadamba na-packaged ke aluminum blisters nke 10 mbak. Ngwugwu nwere ike si 3 10 blisters. Iji ọgwụ ọnọ ntụziaka ntuziaka.

Pharmacology na pharmacodynamics

"Korvitol" bụ a cardioselective beta-blocker, nke na-egosi dịghị sympathomimetic ọrụ na ọ dịghị akpụkpọ ahụ kwụsie ike Njirimara. Ọ nwere antihypertensive, antiarrhythmic, antianginal Njirimara.

Na-egbochi na a obere ego β1-adrenergic anabata nke obi na ebelata guzobere catecholamines ọrụ Camp si ATP, ebelata intracellular calcium ion ugbu a. Adversely BATM, chrono-, Drome na inotropic mmetụta.

TPR ná mmalite nke eji beta-blockers na-abawanye, na mgbe ụbọchị ole na ole iji ọgwụ ọjọọ eme laghachi mbụ larịị, mgbe ogologo oge dị ntakịrị.

Antihypertensive onwunwe mere site ọnụ ke gbasara obi mmepụta na njikọ nke a renin mgbochi nke renin-angiotensin na Central ụjọ usoro, baroreceptor uche mweghachi nke aortic njiko na-emecha ibelata elu ọmịiko mmetụta. Ọ mbelata ọbara mgbali na-ezu ike na n'oge ahụ neuropsychic ibu.

The hypotensive mmetụta a na-enweta na nkeji. N'ihi ya, systolic ọbara mgbali na-lowered mgbe iri na ise nkeji mgbe a kacha abụọ awa. Mmetụta enweta dịruru awa isii. Diastolic ọbara mgbali na-agbanwe agbanwe nwayọọ nwayọọ. Stabilization nwere ike nweta nanị mgbe ọtụtụ izu nke ọgwụgwọ.

Antiangialnye quality nke ọgwụ kpebisiri ike a ọnụ ke myocardial oxygen ina n'ihi na ọnụ ke obi ọnụego. Belata susceptibility mmetụta nke myocardial ọmịiko innervation, ọnụ ọgụgụ na ogo nke rịaworo ọgụ. Enwekwu ahụ ntachi obi.

Antiarrhythmic Njirimara na-egosipụta mgbe wepụ arrhythmogenic ngosipụta mbenata excitation na ectopic imi n'afọ iri na ụma, na mgbochi nke AV-conduction. Mgbe ngosipụta nke supraventricular tachycardia, atrial fibrillation omume na nchọpụta nke imi tachycardia metụtara na ọrịa obi na ọrịa hyperthyroidism, ọgwụ na-ebelata obi ọnụego. Mgbe ụfọdụ, ọ na-eweghachiri imi n'afọ iri na ụma. Ọ aka migraine ma gbochie ya omume na-eme n'ọdịnihu.

Mgbe eji na elu ọgwụgwọ doses, n'adịghị nonselective beta-blockers, o nwere a obere akpọ mmetụta ozu nwere .beta.2-adrenergic anabata, na carbohydrate metabolism. Mgbe eji na nnukwu doses (100 mg kwa ụbọchị) nwere a igbochi mmetụta ma β-adrenoceptor subtypes.

Metoprolol 95% na-etinye obi gị dum site na afo na eriri afọ. The kacha plasma ịta hụrụ mgbe 1-2 awa. N'ihi na-arụsi ọrụ ike metabolism mgbe mbụ na-ewere ọgwụ bioavailability bụ 50%. N'elu ụdi ojiji nke ọgwụ ọjọọ, ọ enwekwu 70%. Iri nri oge ọ bụla na-enwekwu bioavailability nke 20-40%.

"Korvitol 'jikọrọ ọbara ọkọnọ site na 10%, Vd - 5,5 l / n'arọ. Ọ na-aga site na BBB na plantsentarny mgbochi. Anyụpụ na mmiri ara na obere doses.

Fọrọ nke nta niile ọgwụ na-metabolized na imeju. Isi ihe abụọ metabolites nke atọ ji beta-adrenoceptor igbochi onwunwe. The metabolism nke ọgwụ na-ewe akụkụ isoenzyme nke cytochrome P450 (CYP 2D6). Excretion-ewe ihe dị ka awa 3.5. The ọgwụ na-anyụpụ na mmamịrị, na 5% na-aga na-agbanweghi agbanwe.

akụrụ ọrịa inhibit metabolism nke metoprolol. Budata enwekwu bioavailability na imeju. N'ọrụ umi na-adịghị tọhapụrụ site ahụ mgbe hemodialysis.

Egosi maka eji ọgwụ ọjọọ eme

"Korvitol" ga na-eji na ndenye ọgwụ na ọbara mgbali. Ọ na-eji dị ka monotherapy ma ọ bụ na Nchikota na ndị ọzọ antihypertensive mmadụ. The ngosi maka ojiji bụ tachycardia, ịrịa ọrịa obi, myocardial infarction. Ọtụtụ mgbe na-eji "Korvitol 100", analogues igbochi ọrịa strok na obi n'afọ iri na ụma na-anaghị ekwe, migraine mgbochi.

contraindications

"Korvitol 50", na ọgwụ na a onunu ogwu nke 100 mg ghara iwere na cardiogenic ujo. Contraindication eje ozi AV-ngọngọ II na III ogo na sinoatrial ngọngọ. Ejila ọgwụ na a syndrome nke ogbenye imi bradycardia. Ban na elu ọbara odida na obi ọdịda. Mbadamba adịghị aṅụ rịaworo, nnukwu myocardial infarction na ọbara hypotension.

Ị nwere ike ghara ikpokọta ọgwụ "Korvitol 50" (yiri, ma ọ bụrụ na ọ dị mkpa, ga-enyere gị aka ịhọrọ ndị n'imeso dibịa) na ihe monoamine oxidase inhibitors na igba ogwu n'akwara injections "Verapamil".

The ọgwụ na-adịghị gosiri n'oge ara, ndị mmadụ n'okpuru iri na asatọ afọ, na ndị na-hypersensitivity ka metoprolol, ọzọ bekee dị ka akụkụ nke na-esi.

Na pụrụ iche ịkpachara anya na-ahụ ọgwụ ọrịa shuga, bronchial ụkwara ume ọkụ, emphysema, metabolic acidosis, ala ala okpo bronchitis na udi. Naanị n'okpuru nlekọta nke ndị ọrụ ga na-eri na nkà mmụta ọgwụ ndị mmadụ na-elu vaskụla ọrịa, gbasara akụrụ ma ọ bụ hepatic insufficiency. Akọ na ojiji nke mbadamba 'Korvitol "kwesịrị ọrịa na myasthenia gravis, AV-mgbochi nke m ogo, nakwa dị ka na pheochromocytoma, ịda mbà n'obi na hyperthyroidism. Na-elekọta nye iwu ya na psoriasis na ndị agadi ndị ọrịa.

N'oge ime "Korvitol" Erere nye iwu naanị na ikpe nke oké mkpa, mgbe e nwa ebu n'afọ na bradycardia, hypotension, hypoglycemia. Na nke a, na-agwọ ọrịa usoro nwere na-ebe n'okpuru nso nlekọta nke a dibịa. N'ọdịnihu, edu ekpegara nlekọta nke mụrụ nwa ọhụrụ n'oge 48-72 awa mgbe nnyefe.

Metoprolol mmetụta na nwa n'ụbọchị ndị mbụ nke ndụ a na-amaghị, n'ihi ya, ladies na-eji ọgwụ ọjọọ, ọ na-gwara ka nkwụsị ara.

"Korvitol": n'iji atụ aro doses

The ọgwụgwọ onye ọ bụla ndidi kpebisiri ike site dibịa, na-adabere na N'ezie nke ọrịa. Naanị a ọkachamara ga-kara aka site n'ikuku na onunu ogwu nke ọgwụ ọjọọ, "Korvitol". Ntuziaka maka ojiji (analogs ọgwụ si Russian emepụta na-ukwuu dị ọnụ ala karịa) na-akọwa na classic regimens na ọrịa ụfọdụ.

N'ihi ya, na ọbara mgbali na rịaworo ọgwụ ọjọọ n'ime 100 mg ugboro kwa ụbọchị ma ọ bụ 50 mg ugboro abụọ n'ụbọchị. Ọ bụrụ na ọ dị mkpa, na ego nke ọgwụ na-ụba na 100 mg, iwere ugboro abụọ kwa ụbọchị. The kacha ekwe omume kwa ụbọchị dose bụ 200 mg.

Ọtọ ọrịa nke obi-ha, nākpasu ntoputa nke tachycardia, mbụ n'ikuku na-ndinọ ke ichekwa 50-100 mg kwa ụbọchị. A ego nwere ike kewara abụọ ugboro. Ka chọrọ kwa ụbọchị dose ụba 200 mg.

Iji gbochie migraine ọgwụ kenyere 100 mg otu ugboro n'ụbọchị, ma ọ bụ 50 ml na ụtụtụ na mgbede. Mgbe ọgwụgwọ mmetụta a na-enweta, na-dose ga-belata. Usoro a ga-eme nwayọọ nwayọọ na n'okpuru nso ọgwụ na ahụ ike na-elekọta.

Older ndị mmadụ na ọrịa akụrụ na hemodialysis kwa ụbọchị dose na-adịghị belata. Na mmebi imeju na kwa ego nke ọgwụ na-ebelata, na-elekwasị anya ọrịa na-arịa.

Na niile n'elu mgbe, "Korvidol 'na-eji ọnụ, mgbe nri na asa ala na a obere mmiri. Mbadamba ga-elo enweghị ịta. Ọ bụrụ na ọgwụ a na-aṅụbiga ụbọchị ọ bụla, na-ewere ya ga-abịa na nke ụtụtụ. Mgbe e ji ugboro abụọ a mbadamba weere na ụtụtụ na mgbede.

ovadozu

Medicine "Korvitol" bụrụ na ndị ovadozu ozugbo stop inweta. Mgbaàmà eme ihe n'ụzọ na-esi protrude imi bradycardia, ọgbụgbọ, dizziness, ebelata ọbara mgbali, gag mpiaji, cyanosis, arrhythmia, bronchospasm, na-ada mbà, ventricular arrythmia.

Nnukwu ovadozu ogo nkwadebe "Korvitol" (analogues na Russia Ị nwere ike ịzụta ihe ọ bụla na-ere ọgwụ si 30 rubles na n'elu) na-egosipụta dị ka cardiogenic ujo, Coma, AV-mgbochi, ọnwụ nke nsụhọ, cardialgia. A, mbụ ihe ịrịba ama nke oké iji ọgwụ ọjọọ eme iputa mgbe 20 nkeji - 2 awa mgbe ochichi.

Ihe mbụ ọrịa a na-asa afo na kenyere ọgwụ ọjọọ adsorbent. Ọ bụrụ na e nwere a nkọ dobe na ọbara mgbali, onye na-enịm ke Trendelenburg ọnọdụ. Ọ bụrụ na nsogbu tụlee ka a dị oké egwu larịị ma e nwere obi ọdịda, bradycardia, mgbe ahụ ndinọ intravenously na etiti oge nke 2-5 nkeji beta adrenostimulyatorov. The usoro a rụrụ n'ihu a mma N'ihi. Igba ogwu n'akwara injections nwere ike na a dose nke 0.5-2 mg "Atropine sulfate."

Ọ bụrụ na ndị chọrọ mmetụta na-adịghị na-enweta, na-eji ọgwụ ọjọọ eme ihe ndị dị otú ahụ dị ka "dopamine," "nọrepinefrini", "nọrepinefrini" ma ọ bụ "dobutamine". Mgbe ụfọdụ ndinọ 1-10 mg nke "Glucagon" ma ọ bụ ka transvenous intracardiac pacemaker. Na omume nke bronchospasm agbara n'ime a akwara beta adrenostimulyatorov. Ọ bụrụ na ihe ọdịdọ ime, mgbe ahụ ji nwayọọ nwayọọ na anam ntụtụ n'ime a akwara "Diazepam". Hemodialysis na nke a anaghị arụ ọrụ.

mmetụta

Ịnọgide n'ikuku nkwadebe "Korvitol" (ọgwụ) nwere ike ime ka akụkụ nke Central ụjọ na-atụ System isi ọwụwa, muscle adịghị ike, oké ike ọgwụgwụ, ajụ obubu, akpata mgbochi nke uche na n'ahụ Jeremaya mere, paresthesia nke aka na ụkwụ. Egosiwokwa ịda mbà n'obi, nchegbu na-atụ egwu, nsogbu ịta. Nchegbu iro ụra, na-ezighị ezi na nrọ, ehighi ura, mgbagwoju anya, obere okwu na ebe nchekwa ọnwụ. Asthenic syndrome nwere ike ime.

"Korvitol" na ya analogs nwere ike ime ka bịara ikiri ọhụụ, nkụ na soreness nke anya, Mbelata adọka ọmụmụ mmepụta. Na obere okwu, e nwere conjunctivitis, rhinitis. E nwere mkpọtụ na nti.

The ọgwụ nwere ike ime ka malfunction nke obi usoro dị ka imi bradycardia ụdị, elu obi ọnụego, na mberede mgbali Mbelata, hypotension, orthostatic agwa. Na obere okwu, a ọnụ ke myocardial contractility, na-akawanye njọ obi ọdịda, arrhythmia, vasoconstriction. Esogbu patency infarction. kardialgiya ebilite.

Na mgbe nile were nke ọgwụ na-hụrụ dysfunction nke eriri afọ tract, nke e gosipụtara na ụdị ọgbụgbọ, vomiting mpiaji, ihe mgbu ke afo, afọ ọsịsa, akọrọ ọnụ. Ụfọdụ ọrịa kwuru a mgbanwe ndị na-amasị, na-abawanye nke ọrụ dị mkpa nke imeju enzymes. Na obere okwu, ọ na-egosipụta hyperbilirubinemia.

Dị ka a n'ihi nke ọgwụ na-hụrụ dermatological Jeremaya mere. Nke a psoriasis na ya nkpasu-iwe, nācha ọbara-ọbara, ihe ọkụ ọkụ. oké sweating, e kwuru, alopecia reversible ụdị na photodermatosis.

Akụkụ okuku ume na mmetụta okosobode n'ụdị dyspnea na mkpọchi nke gọzie gị amaokwu. Ụfọdụ ọrịa ahụhụ si na iku ume ọkụ ọkụ.

Mgbe ụfọdụ, e nwere a hypoglycemia na hypothyroid ala. Esogbu ọrịa thrombocytopenia, leukopenia, na agranulocytosis. E nwere onye na anataghi n'ụdị itching, aṅụ na rashes. Ọ hụrụ azụ mgbu (nkwonkwo), ibu ibu, ọnwụ nke libido, potency.

adọ aka ná ntị

Na ojiji nke ọgwụ kwesịrị ime a pụrụ iche akara nke obi ọnụego, ọbara mgbali na glucose na-etoju, karịsịa na ọrịa na-arịa ọrịa shuga mellitus. Na nke ikpeazụ ahụ, dose a họọrọ dị na ụkpụrụ nke ọrịa.

Ọ dị mkpa na-akụziri onye ọrịa usoro nke-agụta obi ọnụego na-ezi na mkpa ịkpọ onye dọkịta ma ọ bụrụ na obi ọnụego bụ ihe na-erughị 50 u. / Min.

Ọ bụrụ na a kara aka na elu-dose (200 mg kwa ụbọchị), belatara cardioselective. Na ọrịa na obi ọdịda ọgwụ a rụrụ n'oge oge nke asato.

Ka iwelie ogo hypersensitivity Jeremaya mere (na aggravated anabata akụkọ ihe mere eme) na enweghị mmetụta nke iwebata ot doses nke "Epinephrine".

Na ndabere nke ọgwụ nwere ike njọ mgbaàmà nke elu ọbara mgbasa.

-Ekpochapụ ọgwụgwọ rụrụ nwayọọ nwayọọ, na-ebelata dose na kasị ala ruo ụbọchị iri. Ekwela inikiet inikiet kagbuo ọgwụ, dị ka ọ nwere ike ime ka rịaworo na-amụba ọbara mgbali.

Na ọrịa na rịaworo dose họrọ ya na obi ọnụego bụ hà 55-60 u. / Min na anaghị gafere 110 bpm n'oge emega ahụ. / Min.

Ndị na-kọntaktị anya-amarakwa na n'oge ọgwụ, beta-blockers pụrụ ibelata mmepụta nke adọka ọmụmụ.

Metoprolol na ụfọdụ mkpu mgbaàmà nke hyperthyroidism. Ọrịa na thyrotoxicosis contraindicated mberede ndọrọ ego nke ọgwụ, dị ka a ga-naanị ime ka ọrịa.

Ọrịa ọrịa pụrụ ozugbo ịchọpụta tachycardia kpasue hypoglycemia. "Korvitol" bụghị dịkwuo insulin na-akpata hypoglycemia ma ọ bụ na-egbu oge mgbake nke ọbara glucose nkịtị etoju.

Agadi mgbe na-ewere ọgwụ ga mgbe niile nyochaa ọrụ nke akụrụ, nakwa dị ka na ọrịa na gbasara akụrụ insufficiency.

Ịkpachara anya kwesịrị na-na nkà mmụta ọgwụ a onye a dara ya mbà ala, dị ka mbadamba nwere ike welie ogo nke ọrịa.

Mgbe oge nke ọgwụgwọ kwesịrị izere ịnya ụgbọ na kwụsị metụtara ịta nke anya, na-achọ a ngwa ngwa omume.

N'oge ọgwụgwọ ga-eyi mechiri emechi uwe, n'ihi na ọgwụ nwere ike ime ka photosensitivity.

Gịnị nwere ike dochie anya "Korvitol"?

Mgbe ụfọdụ, ọgwụ nwere ike ime ka a dịgasị iche iche nke mmetụta ma ọ bụ nanị na-adịghị abịa na-eme ihe, otú ahụ ka dọkịta pụrụ ịnọchi anya "Korvitol". Analogs nwere yiri Njirimara, nye otu ọgwụgwọ mmetụta na na-ekewet nke metoprolol tartrate. Ha na-ewu nnọọ ewu na na-ere na ihe fọrọ nke nta ọ bụla na-ere ọgwụ na price nke ụfọdụ n'ime ha sonso iru 50 rubles.

Ndị na-esonụ nwere ike dochie "Korvitol" analogues na otu nọ n'ọrụ mgwa:

• "Betalok".
• "Egilok".
• "Metozok".
• "Metoprolol".
• "Serdol".
• "Vazokardin".
• "Lidalok".

Yiri mmetụta nwere ndị na-esonụ formulations: "Aritel", "Estekor", "Bisomor", "Binelol" "Atenolol", "Kordinorm", "Betacam" "Biol" "Nebilet", "Bisogamma" na ndị ọzọ ọgwụ ọjọọ.

Mgbe dochie otu ọgwụ ọzọ, ịmara na analogue ọ bụghị mgbe nile na-arụ ọrụ dị ka rụọ ọrụ nke ọma dị ka ihe mbụ ọgwụ, na-agafe a usoro nke ule na a otutu nnyocha.

The na-eri nke ọgwụ, reviews

Ọ mgbe niile nwere ike dochie anya "Korvitol" ogbo? Nleba na-ekwu na o siri ike ịchọta a ọgwụ na otu oge nke ihe, n'agbanyeghị eziokwu ahụ na-emepụta a otutu nke ngwaahịa nwere kpọmkwem otu ifịk Efrata. Medicine na-bụ ihe dị oké ọnụ n'ọnọdụ, kama, dị ka ahụmahụ egosiwo, ndị na-erughị oru oma ogbo. Nyocha gosiri na "Korvitol" irè lowers ọbara mgbali na-egbochi mmepe nke migraine.

50 mbadamba 100 mg eri 250-300 rubles, otu ego na a onunu ogwu nke 50 mg bụ nke iji nke 220 -250 rubles.