Ọgwụ "Atokor": ntụziaka ntuziaka, analogue na reviews

High cholesterol etoju ke plasma eme ka mmepe nke atherosclerosis na ọrịa obi na ọrịa usoro.

Ẹmen lipid ẹsụhọde ọgwụgwọ iji pụrụ iche n'aka, otu onye nke bụ ọgwụ "Atokor". Ntuziaka na a na nkà mmụta ọgwụ na-akọwa ya hypocholesterolemic na gipotriglitseridemicheskuyu ọrụ na mbenata ịta nke na-emerụ cholesterol na abụba ndị ọzọ na-ahụ mmadụ.

General e ji mara

The na nkà mmụta ọgwụ na-ezo aka inhibitors nke 3-methylglutaryl-3-hydroxy-CoA reductase. "Dr. Reddy si Laboratories" na-emepụta site India ụlọ ọrụ.

Na nkwadebe "Atokor" onunu ogwu nwere ike 0,020 na 0,010 g

ntọhapụ Ụdị

Emepụta gị n'ụlọnga ke mbadamba ụdị ntekwasa na a na-acha ọcha film. Mbadamba extruded na a triangle udi na biconvex ebupụta na otu onye nke akwụkwọ ozi "A" na-etinyere, na ndị ọzọ na-họpụtara dị ka a dose of "10" ma ọ bụ "20".

Ọdịdị

The n'ọrụ mgwa nke ọgwụ bụ atorvastatin, nke na-anọchi anya micronized calcium trihydrate. Na nkà mmụta ọgwụ "Atokor" onunu ogwu na mejupụtara quantitative n'ọrụ mgwa ubé dị iche iche. Kwa 0,01084 ma ọ bụ 0,02168 g nke atorvastatin calcium trihydrate Ẹkot 0.01 ma ọ bụ 0,02 g dị ọcha atorvastatin.

Mmiri ara ehi sugar, calcium carbonate, croscarmellose sodium, polysorbate 80, hydroxypropyl cellulose, lactose Dt, magnesium stearate mbadamba kpụrụ Ọdịdị.

The casing film kpụrụ si hypromellose 15 cps, propylene glycol, ọcha talc, titanium dioxide.

The otu ihe ahụ ma dose pụtara "Atokor" mejupụtara, na-eduzi ha mkpokọta.

Mbadamba 0.01 ma ọ bụ 0,02 g nke 10 mbak na-arụpụtara na a ọnya packaged ke a kaadiboodu igbe.

usoro nke ihe

Ọgwụ ntụziaka na ngwa na-akọ na nhọrọ, asọmpi retarders 3-methylglutaryl-3-hydroxy-kofermentaA reductase. Ọ bụ ihe dị mkpa enzyme maka akakabarede nke a compound 3-hydroxy-3-metilglyutarilkoenzima A na mevalonic acid nke tupu styrenes na cholesterol.

Ọ bụrụ na ọrịa nke hypercholesterolemia, homozygous heterozygous ezinụlọ na-abụghị ezinụlọ ụdị, na weere dyslipidemia, ọgwụ oriri "Atokor" na-enyere belata ngụkọta cholesterol, cholesterol ahụ na lipoproteins nke ala na nnọọ ala njupụta, triglycerides na apolipoprotein B.

Agwọ ọrịa "Atokor" nkọwa nke ọgwụ na-egosi a nwere maka ejighị n'aka mbadamba bara uru dịkwuo larịị nke sterol na lipoproteins na elu njupụta.

Na imeju mkpụrụ ndụ, na triglycerides holesterolovye ụmụ irighiri ga-aghọ akụkụ nke lipoprotein bekee na-enwe ike ala njupụta. Ha na-zigara ndị plasma, nke banye n'ime n'ime elu anụ ahụ. N'ime ndị a ogige kpụrụ lipoprotein na ala saturation ike catalyzed mmeghachi omume na elu mmekọrita ihe nnabata ụdị formations. All nke a bekee ike welie mmepe nke atherosclerotic ọrịa.

Action Atorvastatin e ji a nnọọ na persistent abawanye na arụmọrụ nke LDL-ihe nnabata okụre, mbenata na-emerụ cholesterol kasịnụ na elu hypercholesterolemia nke homozygous butere n'aka ụdị.

Pụtara "Atokor" ntụziaka na-egosi ya ike na Lower plasma cholesterol etoju na lipoprotein site inhibiting HMG-CoA reductase enzyme. Ọ slows ala guzobere cholesterol na imeju mkpụrụ ndụ, enwekwu ọnụ ọgụgụ nke ihe nnabata formations nke lipoproteins na ala saturation na cell membranes. Nke a na enhances kpọọ na catabolism nke cholesterol si lipoprotein ụmụ irighiri nke ala ịta.

Gịnị na-eji

Agwọ ọrịa "Atokor" User Ngwa na-adụ ọdụ na-ewere mbadamba na isi ihe ịrịba ama nke mụbara cholesterolemia heterozygous ụdị, obodo ma na-abụghị obodo na-amụba cholesterol ịta, weere geterlipidemii, mụbara ego nke plasma triglyceride ụmụ irighiri.

Ha na-ndinọ na Nchikota na dietary ntụziaka maka ẹsụhọde elu cholesterol larịị ke lipoproteins na ala saturation, apolipoprotein B na triglyceride ogige.

Mbadamba belata plasma ịta nke cholesterol na LDL cholesterolemia na elu homozygous ezinụlọ ụdị, mgbe dietary nri na ndị ọzọ na-abụghị pharmacological ụzọ adighi ike.

Olee na-

Agwọ ọrịa "Atokor" ntuziaka maka ojiji tụrụ aro ịṅụ nanị mgbe nhọpụta nke a ọkọlọtọ hypocholesterolemic nri onye ọrịa, nke a ga-eji n'oge ọgwụ. Dosing atọrọ iche iche maka onye ọ bụla-enwe ndidi, nke a na-gbakọọ na mbụ larịị nke cholesterol na lipoproteins na ala saturation. Ọ dị mkpa ka gaa na akaụntụ ahụ bu n'obi were, irè nke ọgwụgwọ na "Atokor 'àmà.

A, mbụ onunu ogwu bụ Ẹkot 0.010 g na otu oge kwa ụbọchị. The ojiji nke mbadamba bụ na ọ bụghị oge nke ụbọchị na nri oriri.

The onunu ogwu nke kwa n'aka 0,010 na 0,080 g họrọ si mbụ ajụjụ egosi nke na-emerụ cholesterol, lekwasịrị ogige na onye irè. Na mbụ na-adọ nke ngwa na site na ịba ụba ịta nke ọgwụ ga-ọkara a ọnwa ịlele larịị nke plasma abụba, ma kpatụ dose dị mkpa.

Primary hypercholesterolemia na jikọtara hyperlipidemia agwa emeso kwa onunu ogwu na 0,010 g

Therapeutic ọrụ emee n'ime 14 ụbọchị, na kacha arụmọrụ bụ omume mgbe otu ọnwa. Ruo ogologo oge iwere na-eme ka o kwe omume ịnọgide na-enwe ọgwụgwọ mmetụta.

Ọgwụ "Atokor" na Russian ntuziaka nwere ozi na terapiigiperholesterinemii nke homozygous ezinụlọ ụdị. A, kenyere kwa onunu ogwu na 0.080 g Na ojiji bụ a ọnụ ke LDL cholesterol ụkpụrụ ruo 40%.

Akụkụ nke ọgwụgwọ

The mbadamba "Atokor 'ntuziaka maka ojiji na-ike na-atụ aro tupu ịmalite iji ọgwụ ga-ahụ ihe na-akpata a abụọ na-abawanye nke cholesterol ụkpụrụ. A ihe gụnyere ọrịa shuga, ogbenye ọgwụgwọ nke ọrịa shuga, hypothyroidism, nephrotic usoro disproteinemicheskih mgbanwe, okpo ọrịa imeju. Nke a nwere ike ịgụnye n'ihu ọgwụgwọ na ọgwụ ọjọọ ndị ọzọ na-aba n'anya riri ahụ. Nanị mgbe ịlụ Bibie nke n'elu ihe mere, ị dị njikere iji mbadamba "Atokor".

Ọbụna tupu ọgwụ a rụrụ mkpebi siri ike nke lipid itule n'etiti ngụkọta cholesterol, LDL cholesterol na na HDL cholesterol na triglycerides.

E nweghị ndị na data na ojiji nke ọgwụ na ụmụaka bi, ka ndị a mbadamba na-bụghị gosiri maka ụmụaka.

Na ọgwụgwọ nke agadi ọrịa, onye afọ bụ ihe karịrị afọ 60, bụ onye na-abawanye na plasma etoju nke nọ n'ọrụ gị n'ụlọnga akụrụngwa 40%.

Bụrụ na nke mebiri gbasara akụrụ ịrụ ọrụ adịghị mkpa ka ịhazie dose, dị ka a ọnọdụ adịghị emetụta atorvastatinovoe ọdịnaya ke n'ọbara na irè nke ẹsụhọde ọjọọ cholesterol.

E nwere ihe gosiri na nke a na klas nke ọgwụ ọjọọ eme ka mmepe rabdomioliznoy myopathy na ezughi oke ọrụ nke akụrụ na nnukwu ụdị. Na ọrịa ndị a site ọgwụ ga-tụfuo n'oge.

Preparations na ndabere nke atorvastatin kwesịrị iwere nke ọma ndị na-aṅụ oké mmanya ma ọ bụ nwere ọrịa imeju na n'oge gara aga.

Akparamagwa nke inhibitors nke HMG-CoA reductase enzyme nwere ike mgbanwe Biochemical egosi nke imeju ọrụ. N'ihi na-adọ echichi nke dị otú ahụ imebi mkpa ka o duzie nwale nke hepatic ọrụ, na mgbe ọnwa 3 mgbe na-ewere ọgwụ mepụta a ego tupu ọgwụgwọ.

Drug "Atokor" na Russian ntụziaka na-agụnye ihe ọmụma banyere a nnọọ na-abawanye na plasma ụkpụrụ nke nọ n'ọrụ mgwa na-arịa ọrịa imeju, na-ata ahụhụ site na aṅụrụma. Nwa Oge ma ọ bụ zuru ezu odida nke ọgwụ na-alaghachikwuru imeju transaminase ọrụ na mbụ eku. Ọtụtụ ndị ọrịa adịghị kwusi na ojiji nke ọgwụ ọjọọ na obere doses, ma ọ dighi oghom Jeremaya mere ịmaliteworị.

Na ọgwụgwọ nwere ike na-eche anya ntughari, ịzụlite iro ụra, otú na oge nke ngwa nke mbadamba ọrịa na-aju ịchịkwa iga na ndị ọzọ na mgbagwoju ngwá.

Ònye kwesịrị iji

On agwọ ọrịa "Atokor" contraindications-agụnye onye na ubara uche na onye ọ bụla mgwa nke agwọ ọrịa.

O buru banyere nnukwu ọrịa imeju na elu ebighị nke transaminase ọbara enzymes mgbe ọrụ ha bụ 3 ugboro elu karịa elu ịgba nke nkịtị ụkpụrụ.

The ọgwụ na-adịghị kenyere ndị inyom nke omumu afọ ndị na-adịghị eji ezigbo igbochi afọ. Contraindication bụ a ọnọdụ nke ịmụ nwa na ara.

Medicine anaghị emeso ụmụ na-eto eto n'okpuru afọ 18.

N'ihi ọnụnọ nke mmiri ara ehi na ihe ndị mejupụtara nke mbadamba 'Atokor "sugar ntụziaka na ngwa machibidoro eji ha a butere n'aka ekweghị ibe nọrọ na galactose ụmụ irighiri ihe, na a enweghị lactase na glucose-galactose malabsortsii.

analogs

E nwere ọnụ ọgụgụ dị ukwuu nke ọgwụ ọjọọ eme ihe na-adabere atorvastatin. Cholesterol-ẹsụhọde ọgwụ ọrụ "Atokor" ntụziaka ntuziaka. Analogs nwekwara ike belata larịị nke ọjọọ cholesterol ke iyịp.

One dị otú ahụ ọgwụ bụ a na-agwọ ya maka Slovenian "Atoris", nke a emeputa nke nkwonkwo ngwaahịa ụlọ ọrụ "Krka, Novo Mesto." Ọ na-emepụta na ụdị mbadamba na-arụsi ọrụ ike mgwa ọdịnaya nke 0.010 g, 0.020 g, 0.040 g

The ọgwụ na-aduak iwepụ a hyperlipidemic ọnọdụ, agaghi asu parameters dị mkpa iji belata ngụkọta cholesterol, lipoprotein cholesterol na ogige na a ala saturation, ego nke apolipoprotein na ụmụ irighiri nke triglyceride n'ime ọbara iyi.

Drug emeso ndị mmadụ na hypercholesterolemia polygenic heterozygous homozygous ezinụlọ ụdị.

Site n'enyemaka nke "Atoris" ọgwụ ọjọọ na-enwekwu ịta nke cholesterol na lipoproteins na elu saturation.

Ọzọ Slovene analogue atụle ọgwụ "Tulip," nke e mere ugbu a "Amalek Pharmaceutical Company". E nwere atọ Dosages film-ntekwasa mbadamba: 0.01 g, 0,02 g na 0,04 g

The ọgwụ na-owụt mkpochapu isi forms of hypercholesterolemic na jikọtara hyperlipidemic ọnọdụ, maka ọgwụgwọ nke elu cholesterol ji heterozygous na homozygous ezinụlọ ụdị.

N'otu aka ahụ, n'aka-ewere Indian na nkà mmụta ọgwụ "Astin", nke na-emepụta site na enterprise "Micro Labs Limited". Ọ bụ dị na abụọ Dosages: na 0,010 g na 0,020 g nke atorvastatin.

The ọgwụ na-kenyere na ihe mụbara lipid ọdịnaya, mgbe ọ na-adịghị hụrụ mmetụta dị mma nke dietary na ihe omume ndị ọzọ.

Indian n'ichepụta a agwọ ọrịa "Storvas" dabeere na calcium nnu nke atorvastatin. Arụpụtara site "Ranbaxy Laboratories Limited" n'ụdị nke a mbadamba ntekwasa na a n'ọbọ abụọ Dosages: na 0,010 g na 0,020 g

Drug "Storvas" belata elu ọdịnaya nke ngụkọta cholesterol, LDL cholesterol ụmụ irighiri na, na ịta nke apolipoprotein triglyceride ogige ke akpan, na nonmarried heterozygous ezinụlọ hypercholesterolemic ọnọdụ, nakwa dị ka mbuaha hyperlipidemic ọrịa.

Ọgwụ na-ebelata-ekwe omume nke myocardial infarction myocardial pụtara ala nke uru ahụ, ọrịa strok na mgbanwe na-arịa ọrịa ọbara. Mbadamba nwayọọ na ná nke akwara atherosclerotic ọnọdụ.

American counterpart bụ ọgwụ "Lipitor" na-emepụta site "Pfizer". Ọ na-emepụta na ụdị mbadamba ntekwasa na a shei na atọ Dosages: na 0.010 g, 0.020 g, 0.040 g The ọgwụ a na-eji iji kpochapụ hypercholesterolemic-ekwu, nke dị iche iche nke si malite.

Nyocha

Medicine "Atokor" User Ngwa kọwara dị ka pụtara na elu pụtara nrụpụta. Ọtụtụ ndị ọrịa na elu plasma kasịnụ nke na-emerụ cholesterol, mgbe a N'ezie nke iji na-na-mma. The ụkpụrụ nke ngụkọta cholesterol na LDL cholesterol na-ebelata ka a nkịtị larịị, nke na-ebelata ohere nke na-emepe emepe atherosclerosis, na ischemic ọnọdụ.

The ọgwụ bụ nke usoro mgbasa ozi na-ezi tolerability, ma na ụfọdụ ndị ọrịa ya nwere ike ime ka a na-egbu oge stool, bloating, ihe mgbu ke afo, ọgbụgbọ, afọ mgbu. E nwere isi ọwụwa, nsogbu ụra. Ka ịzụlite jerky, asthenic na myalgic ọnọdụ.

Na obere okwu, mmetụta ndị egosiwokwa myositis, myopathy, paresthesia, elu neuropathy, pancreatitis, ịba ọcha n'anya, cholestatic jaundice.

Mbadamba nwere ike ime ka anorexia, vomiting, hepatotoxicity ngosipụta, alopecia, pruritic ngosipụta nke rashes, enweghi ike, cataracts, hyper- ma ọ bụ hypoglycemia.