Ọgwụ "Doxorubicin": ntụziaka ntuziaka, reviews, photos, ntọhapụ ụdị, onunu ogwu, nchekwa. "Doxorubicin-Lance": ntuziaka maka ojiji

The cancer bụ nnọọ ize ndụ ka ndụ mmadụ. Ọ mejupụtara nke ịza na-achịkwaghị proliferating mkpụrụ ndụ, nke na-enwe ike iru n'ime gburugburu anụ ahụ na metastasize ka ndị ọzọ na akụkụ.

Mmepe nke ọgwụ ọjọọ na ọgwụgwọ nke ọrịa ndị dị bụ ihe dị mkpa ọrụ. N'ụzọ dị mwute, ruo ugbu a na ọ dịghị onye ruo mgbe ọgwụgwụ na m kpebiri. Ọ bụ ezie na e nwere ndị ka ọgwụ ndị na ike jiri nkewa nke akpụ mkpụrụ ndụ. Otu n'ime ha kwuru na ọgwụ "Doxorubicin". Ntuziaka maka ojiji na a foto nke ọgwụ ga-kpuchie ke ibuotikọ emi. Na ya na ị ga-achọta ihe ọmụma banyere otú na-kwuru n'aka na nke na-etolite na ọ bụ maka ire ere, na ndị ọzọ.

Packaging, mejupụtara, udi na nkọwa

Na ihe n'ụdị na-eresị "Doxorubicin"? Ntuziaka maka ojiji na-egosi ndị na-esonụ ụdị nke ngwaahịa a:

• Lyophilizate maka nkwadebe nke ihe ngwọta maka intravascular na intravesical ogwu ogbugba. Ọ bụ ọbara ọbara-acha odo odo porous uka na e dere ihe ndị nọ n'ọrụ umi dị ka doxorubicin hydrochloride. Dị ka ndị ọzọ Efrata iji mannitol. Ọgwụ a na-eresị na karama, nchọ na a kaadiboodu igbe.
• Lekwasị maka amị a ngwọta maka intravascular na intravesical ogwu ogbugba. Ọ bụ a-acha uhie uhie na uzo mmiri mmiri nke nwere doxorubicin hydrochloride na dị na karama na katọn.

The pharmacology nke ọgwụ

Gịnị bụ nke a na nkà mmụta ọgwụ dị ka "Doxorubicin"? Ntuziaka maka ojiji (ntọhapụ ụdị ọgwụ e kwuru n'elu) na-akọ na ọ bụ ihe mgbochi-akpụ anthracycline ogwu mgbochi, nke e kewapụrụ omenala nke ero Streptomyces peucetius. Ọ bụ ike na-akpa antimitotic na antiproliferative mmetụta.

Mmekọrịta na DNA, na agwọ ọrịa na-egbochi RNA polymerase, DNA polymerase na topoisomerase ụdị 2, na activates na mmepụta nke free radicals na-eme na cell mgbidi. Dị ka a n'ihi nke ndị dị otú ahụ na mmetụta slows DNA replication na ndu nucleic acid njikọ.

Ọ gaghị ekwe omume ka ọ ghara mara eziokwu ahụ bụ na anyị na-atụle ihe e nwere a kpọmkwem cytotoxic mmetụta. Mkpụrụ ndụ igosipụta a akpan akpan uche ọgwụ na G2-adọ na S-adọ nke ndụ ha.

kinetic Njirimara

Gịnị kinetic parameters pụta ụwa ọgwụ "Doxorubicin"? Ntuziaka maka ojiji na-ekwu na mgbe igba ogwu n'akwara ogwu ogbugba, na ngwá ọrụ mgbe niile na-ekesa multiphase. N'oge mbụ 5 nkeji nke agwọ ọrịa ngwa ngwa weghaara anụ ahụ, na ya ịta na ọbara mbelata ngwa ngwa. Dị ka nke abụọ na-adọ ya, ọ na-rụrụ ngwa ngwa ọgwụ ụmụ irighiri si arọ.

Ụtụtụ ifịk ọgwụ na imeju, akụrụ, splin, akpa ume na myocardium. Ọ na-penetrates Plasenta na ọ na-anyụpụ na mmiri ara.

Nzaghachi plasma-edozi emee site 75%. Metabolism ọgwụ na imeju, si otú akpụ ifịk emepụta dị ka doxorubicinol.

N'oge Mbelata free radicals enzyme njikọ pụrụ imetụta mmepe nke gbasara obi toxicity.

Ọkara ndụ-nke doxorubicin na yiri doxorubicinol na bụ banyere 20-48 awa.

Odika 40% nke dose nke ọgwụ a tọhapụrụ ha na bile, na na 6-11% nke doxorubicin na-eji ya emepụta, n'ihi na 5 ụbọchị na-hụrụ na mmamịrị.

egosi

ọgwụ ọjọọ, "Doxorubicin" nwere ike họpụtara na ihe ọrịa?

Ntuziaka maka ojiji (maka eriri afo cancer bụ ngwá ọrụ na-eji ukwuu mgbe) o na-ekwu na nkà mmụta ọgwụ-eme nke ọma mgbe:

• thyroid gland cancer, Kaposi si sarcoma na Ewing;
• Wilms 'akpụ, gastric cancer, obere cell ụdị ọrịa cancer akpa ume;
• insulinoma, ara cancer, mesothelioma;
• esophageal cancer, carcinoid, neuroblastoma;
• osteogenic sarcoma, bụ isi hepatocellular carcinoma, ndị na-abụghị Hodgkin si lymphoma ;
• Cancer nke prostate gland, cancer nke isi na olu, ịza aza thymoma;
• cervical cancer, ụfọdụ ụdị nke testicular etuto ahụ;
• eriri akpa nwa sarcoma, endometrial cancer, Hodgkin ọrịa;
• rhabdomyosarcoma, nnukwu leukemia;
• adịghị ala ala lymphocytic leukemia, multiple myeloma.

contraindications

Gịnị bụ ọnọdụ nke onye ọrịa nye iwu machibido ya ọgwụ "Doxorubicin"? Ntuziaka maka ojiji, n'ezie oncologists na-ekwu na ngwá ọrụ na-egosi bụghị nnọọ irè:

• uche na doxorubicin ma ọ bụ ọgwụ ọjọọ ndị ọzọ bekee, dị ka nke ọma dị ka ndị nnọchianya nke anthracyclines na anthracenediones;
• tupu ọrịa, ma ọ bụ ndị ọzọ so anthracycline anthracenediones na ịmachi doses, nakwa dị ka mmebi imeju (oké), myocardial infarction, arrhythmias, nnukwu malitere ịrịa ọrịa na obi ọdịda (maka igba ogwu n'akwara ochichi);
• ịza aza etuto ahụ, germinating na mgbidi nke eriri afo, urinary tract-efe efe na cystitis (maka intravesical).

Ihe ókè ịkpachara anya, a ọgwụ ga-eji maka ndị na-natara ọzụzụ kpụ ọkụ n'ọnụ iji ọgwụ, nakwa dị ka ihe ize ndụ ihe maka cardiotoxicity, mebiri nke imeju, ụmị ọkpụkpụ infiltration nke cancer mkpụrụ ndụ na ibu oké ibu.

Ke adianade do, jiri nlezianya tụlee ọgwụ na-kenyere ụmụ na mmadụ ndị agadi, na dị ka akụkụ nke a multi-umu na multicomponent antitumor ọgwụ.

Drug "Doxorubicin": ntuziaka maka ojiji, onunu ogwu

Dị ka ntụziaka, na-ewere ọgwụ ike ga-ndinọ intraarterially, intravenously na intravesically. Ọ kwesịkwara kwuru na ngwá ọrụ a ga-eji singly ma ọ bụ na Nchikota na ndị ọzọ cytostatic ọgwụ ọjọọ dị iche iche Dosages.

Reconstituted ọgwụ ngwọta "Doxorubicin" bụ na-eji ozugbo ya rụpụta.

Igba ogwu n'akwara ọgwụ Nwa

Na-atụ aro usoro onunu ogwu nke monotherapy "Doxorubicin" kwa okirikiri bụ 60-75 mg / sq. m ọ bụla izu atọ. A, ọgwụ na-agbara otu ugboro. Otú ọ dị, nke a dose nwere ike ndinọ na multiple injections (ke ichekwa 25-30 mg / sq. M kwa ụbọchị nke mbụ 3 ụbọchị nke okirikiri).

Iji belata-egbu egbu mmetụta nke usoro eji kwa izu ochichi nke 10-20 mg / sq. m ugboro n'izu.

Mgbe jikọtara ndị ọzọ anticancer mmadụ n'ọrụ agwọ ọrịa na-ndinọ na a onunu ogwu okirikiri ke ichekwa 30-60 mg / sq. m 4 ọ bụla izu.

Ugboro ugboro ọmụmụ ọgwụgwọ rụrụ nanị mgbe ebibi ndị nile na mgbaàmà nke toxicity.

Mkpokọta dose nke ọgwụ ekwesịghị ịbụ ihe karịrị 550 mg / sq. m.

Intra-ọbara ochichi nke ihe gị n'ụlọnga

Olee otú bụ intra-ọbara injection "Doxorubicin" ọgwụ ọjọọ? Eduzi na-ekwu na-enye sidetone ndị mmadụ na hepatocellular carcinoma ifịk agwọ ọrịa ka ga-ndinọ ndị nkịtị hepatic akwara na a onunu ogwu nke 35-150 mg / sq. m. N'otu oge etiti oge n'etiti cycles hara si 3 izu 3 ọnwa.

The mmeghe nke ọgwụ n'ime eriri afo

Dị ka eriri afo agbara ọgwụ "Doxorubicin-Teva"? Ntuziaka maka ojiji na-akọ na a onunu ogwu pụtara n'ihi intravesical ochichi kwesịrị 35-50 mg kwa echichi.

Medical usoro a ga-rụrụ na etiti oge nke 7-28 ụbọchị, dabere na nzube (mgbochi ma ọ bụ ọgwụgwọ).

Ịta nke ọgwụ ngwọta kwesịrị 1 mg / 1 ml mmiri ngwọta ma ọ bụ nke anụ ahụ.

Instillation a rụrụ n'ime 2 awa. Ná ngwụsị nke onye ọrịa ga-efu eriri afo.

mmetụta

Nkwadebe "Doxorubicin", nke ntụziaka a kọwara n'elu nwere ike ime ka ndị na-esonụ n'akụkụ Jeremaya mere:

• vomiting, abdominal mgbu, ọgbụgbọ, afọ, stomatitis, afọ ọsịsa, esophagitis, onu mucosa hyperpigmentation, anorexia, mụbara bilirubin ịta na ọbara, eriri afọ ọbara ọgbụgba, mụbara hepatic transaminases;
• dose-dabere reversible leukopenia, thrombocytopenia, anaemia, leukopenia, neutropenia;
• imi tachycardia, atrioventricular ngọngọ, tachyarrhythmia ụdị congestive obi ọdịda, bradycardia, thrombophlebitis, Ya ùkwù alaka ngọngọ, abnormalities na ECG, ventricular arrythmia, akpa ume embolism, phlebitis, thromboembolic nsogbu;
• amenorrhea, oligospermia, hyperuricemia, urinary red staining, azoospermia;
• conjunctivitis, keratitis, lacrimation;
• elu neurotoxicity, ọdụdọ, amaghị onwe;
• edema, reversible alopecia, photosensitivity, anụ hyperpigmentation, ọkụ ọkụ, itching, oké mgbu, ihe ọkụ ọkụ, erythema, ooh epidermis;
• dermatitis, ọkụ ọkụ, bronchospasm, anụ flushing, anaphylaxis;
• Obodo phlebitis, akara mbufụt, fleboskleroz, thrombophlebitis, obodo mgbu, anụ ahụ necrosis;
• polyuria, nocturia, dysuria, necrosis nke eriri afo membranes, hematuria, ahụ erughị ala, na-egbu mgbu urination;
• erythematous striation na injection saịtị;
• ike ọgwụgwụ, malaise, fever, akpata oyi, mmepe nke lymphocytic ma ọ bụ myelocytic leukemia (nnukwu), hyperuricemia, tides, nephropathy;
• ọnyá afọ 12 duodenal / gastric, biliary sclerosis.

mgbaàmà nke ovadozu

Gịnị bụ ihe ịrịba ama nke ovadozu-eme mgbe ị na-eji a ọnụ ọgụgụ buru ibu nke "Doxorubicin" ọgwụ ọjọọ? Ntuziaka maka Iji na-ekwu na ihe ovadozu nke ego nwere ike ime ka na-egbu egbu mgbaàmà na-egosipụta site na digestive usoro, nakwa dị ka ndị dị oké myelosuppression. Ke adianade do, elu doses nke ọgwụ pụrụ ịbụ nnọọ mfe ime ka nnukwu ọrịa obi.

Ka ọgwụ ahụ ọgwụ ọjọọ, "Doxorubicin" adịghị adị. Na ovadozu nweworo ndinọ symptomatic ọgwụ. Ọzọkwa, ọ na-ụlọ ọgwụ ma na-emeso ya na antibacterial ọgwụ ọjọọ.

ọgwụ interactions

Ọ ga-ekwe omume na ikpokọta na ọgwụ ọjọọ ndị ọzọ ọgwụ ọjọọ, "Doxorubicin"? Ntuziaka maka ojiji na-egosi na mgbe ị na-eji ngwá ọrụ a na Nchikota na ndị ọzọ cytotoxic ọgwụ ọjọọ mgbe gosipụtara ha mmako toxicity.

Mgbe a Nchikota ọgwụ na ndị ọzọ cytotoxic ọgwụ ọjọọ, nke nwere cardiotoxicity (eg, "Fu" ma ọ bụ "Cyclophosphamide"), na-achọ ịkpachara anya nlekota nke obi n'oge dum nke ọgwụ.

"Streptozocin" enwekwu ọkara ndụ "Doxorubicin".

The ọgwụ "Doxorubicin" onye ọrịa nwere ike na-egosi ihe ịrịba ama nke nnukwu hemorrhagic cystitis mgbe omume "cyclophosphamide", nakwa dị ka ike onu nke imeju toxicity mgbe omume "mercaptopurine."

The iji "Paclitaxel" tupu n'ezie iwebata "Doxorubicin" nwere ike kpasuo na-abawanye na ọbara ịta nke ikpeazụ.

Gịnị ọgwụ ọjọọ na-egbu si eji ọgwụ ọjọọ, "Doxorubicin"? Ntuziaka maka ojiji (n'ihi na ụmụ anụmanụ na-adịghị kenyere) na-akọ na ngwá ọrụ a na-ekwesịghị weere na ndị ọzọ ọgwụ ọjọọ. Dị ka ihe atụ, ọ bụ pharmaceutically dakọtara na "heparin", "Dexamethasone", sodium succinate, "hydrocortisone", "cephalothin", "aminophylline", "Fu" na ndị ọzọ anticancer ọgwụ ọjọọ.

Mgbe jikọtara ndụ malitere ịrịa ọgwụ mgbochi bụ omume malitere ịrịa replication na ụba n'akụkụ Jeremaya mere na ibelata antibody nsụchi a ọrịa ahụ na omume ojiji nke vaccines.

Specific kwe nkwa na iji ọgwụ ọjọọ eme

Ihe i kwesịrị ịma tupu eji "Doxorubicin-Lance"? Ntuziaka maka ojiji na-egosi na na ọgwụgwọ antineoplastic mmadụ dị mkpa na-ebu mgbe niile nlekota nke imeju ọrụ, foto nke elu ọbara, ECG na ultrasound nke obi.

sales ọnọdụ, usoro nchekwa na adị ndụ

Ebe ga ọgwụ "Doxorubicin-Lance"? Ntuziaka maka ojiji na-akọ na ngwá ọrụ a ga-nọ na a akọrọ na ọchịchịrị ebe okpomọkụ adịghị gafere ise degrees.

The agwọ ọrịa na-wepụtara na pharmacies site ọgwụ naanị. Ya adị ndụ bụ afọ abụọ.

Price na analogues

The na-eri nke ọgwụ a na-ewere 120-150 rubles na 5 ml. Ọ bụrụ na ọ dị mkpa na ọ ga-anọchi dị otú ahụ dị ka "Doxorubicin-Teva", "Lachema Doxorubicin", "Onkodoks 50", "10 Onkodoks", "Doxorubicin-Ebewe", "CRC-Doxorubicin" na ndị ọzọ.

Consumer reviews nke ọgwụ

Ugbu a ị maara otú e si eji ọgwụ ọjọọ, "Doxorubicin". Ntuziaka maka ojiji na nchekwa nke ọgwụ na-adade n'elu.

Oputara a ọnụ ọgụgụ buru ibu nke n'ji reviews metụtara na oké njọ oghom Jeremaya mere na-eme n'oge ọgwụgwọ na ọgwụ. Iji ihe ndị a na-esịtidem ngwa aka, na-adịgide adịgide na-eche ọrịa, ntutu isi ọnwụ na e guzobere ọnyá na-agbanye saịtị.

Na ezi ozi ha bụ oké ụkọ. Ma nke a abụghị ihe ijuanya, ebe irè nke anticancer ọgwụ kwesịrị ịtụle nanị ahụmahụ ọkachamara, dabeere na a ọnụ ọgụgụ buru ibu nke iche iche ihe: na ụdị monotherapy ma ọ bụ Nchikota ọgwụ, a cancer, ọrịa na-arịa, na ndị ọzọ ogologo oge pụta.