Ọhụrụ ọgbọ nke NSAIDs: reviews, ndepụta ahịa

A otutu nke enweghị nchịkwa mgbanwe na-erukwa na ahụ, Bilie mgbu. Mbuso ndị dị otú ahụ ihe mgbaàmà mepụtara NSAIDs ma ọ bụ ndị na-abụghị steroidal mgbochi mkpali n'ụlọnga. Ha na-ọma anesthetized, belata mbufụt, belata ọzịza. Otú ọ dị, ọtụtụ ọgwụ na-enwe mmetụta. Nke a na-ebelata-ekwe omume nke ha na ojiji maka ụfọdụ ọrịa. Modern pharmacology mepụtara ọhụrụ ọgbọ nke NSAIDs. Ndị dị otú ahụ ọgwụ ọjọọ eme ihe na-ukwuu na-erughị yiri ka ime ka wetara Jeremaya mere, kama ịnọgide na-irè ọgwụ ọjọọ megide mgbu.

mmetụta nke ụkpụrụ nke

Gịnị ọ bụ n'ihi na mmetụta nke NSAIDs na ozu? Ha na-eme na cyclooxygenase. Cox nwere ihe abụọ isoforms. Onye ọ bụla n'ime ha na-eburu ya ọrụ. Dị otú ahụ enzyme (Cox) na-akpata a chemical mmeghachi omume n'ihi na arachidonic acid na-aga n'ime prostaglandins, thromboxanes na leukotrienes.

Cox-1 bụ maka mmepụta nke prostaglandins. Ha na-echebe afo si wetara mmetụta nwere mmetụta na ịrụ ọrụ nke platelet, na mmetụta nke a mgbanwe gbasara akụrụ ọbara.

Cox-2 bụ ejikari anọghị na bụ a kpọmkwem enzyme mbufụt synthesized site cytotoxins, nakwa dị ka ndị ọzọ ogbugbo.

Dị otú ahụ edinam nke NSAIDs dị ka mgbochi nke Cox-1, na-eburu a plurality nke n'akụkụ-mmetụta.

ọhụrụ tolite

Ọ bụ mba na nzuzo na preparations nke mbụ ọgbọ nke NSAIDs nwere mmetụta dị njọ n'ahụ gastric mucosa. Ya mere, ndị ọkà mmụta sayensị mee ihe - iji belata ekwesighi mmetụta. a ọhụrụ ntọhapụ ụdị e mepụtara. N'ọnọdụ dị otú formulations n'ọrụ mgwa ihe bụ na ndị pụrụ iche envelopu. The Capsule na e mere nke ndị dị otú ahụ ihe na-adịghị igbari na acidic na gburugburu ebe obibi nke afo. Ha malitere daa naanị mgbe kụrụ ke gootu. Ọ bụ ike belata mgbakasi utịp ke gastric mucosa. Otú ọ dị, usoro nke mmerụ wetara eriri afọ tract mgbidi ka na chebere.

Nke a kpaliri chemists synthesized a kpam kpam ọhụrụ compound. Previous ọgwụ ha fundamentally dị iche iche usoro nke edinam. a ọgbọ ọhụrụ nke NSAIDs ji a nhọrọ mmetụta Cox-2, nakwa dị ka mgbochi nke prostaglandin mmepụta. Nke a-enye gị ohere iru niile dị mkpa mmetụta - analgesic, antipyretic, mgbochi mkpali. Na nke a, ndị ọhụrụ ọgbọ nke NSAIDs iwelata mmetụta na ọbara coagulation, platelet ọrụ gastric mucosa.

Mgbochi mkpali mmetụta ruru ala permeability nke vaskụla mgbidi, nakwa dị ka a ọnụ na-amụba a dịgasị iche iche nke mkpali ogbugbo. N'ihi na nke a ikpughe na-ebelata iyatesịt nke akwara mgbu anabata. Mmetụta na ụfọdụ thermoregulatory emmepe na ụbụrụ, ekwe ọhụrụ ọgbọ nke NSAIDs bụ magburu onwe Lower n'ozuzu okpomọkụ.

egosi

N'ịbụ ndị a maara mmetụta nke NSAIDs. Mmetụta dị otú ahụ ọgwụ ọjọọ eme ihe iji na-egbochi ma ọ bụ na mbenata aza. Ọgwụ a na-enye ihe ndị magburu onwe antipyretic mmetụta. Ha na mmetụta na-ahụ nwere ike jiri ya tụnyere ihe mmetụta nke narcotic analgesics. Ke adianade do, ha na-enye ihe analgesic, mgbochi mkpali na mmetụta. NSAIDs oji obosara ọnụ ọgụgụ na a na-adakarị na ntọala ma na-adị kwa ụbọchị ndụ. Taa ọ bụ otu n'ime ndị kasị ewu ewu ọgwụ ọgwụ ọjọọ.

The nti mmetụta na-kwuru na ndị na-esonụ ihe:

1. Ọrịa nke nweekwa usoro. Na dị iche iche sprains, bruises, ogbu na nkwonkwo ọgwụ data bụ nanị irreplaceable. NSAIDs eji na osteochondrosis, mgbu arthropathy, ogbu na nkwonkwo. The ọgwụ nwere mgbochi mkpali mmetụta na scoliosis, herniated discs.
2. N'oké ihe mgbu. Preparations nnọọ ihe ịga nke ọma na-eji na biliary colic, ọrịa ụmụ nwanyị ọrịa. Ha kpochapụ isi ọwụwa, ọbụna oké isi ọwụwa, akụrụ erughị ala. NSAIDs na-ọma na-eji maka ọrịa na postoperative oge.
3. High okpomọkụ. Antipyretic mmetụta na-enye ohere iji ọgwụ ọjọọ eme na ọrịa dị iche iche ọdịdị nke ma ndị okenye ma ụmụaka. Ndị a ọgwụ ọjọọ eme ihe ndị dị irè ọbụna na a fever.
4. Thrombus guzobere. NSAIDs bụ ọgwụ ọjọọ antiplatelet. Nke a na-enye ohere ha itinye na ischemia. Ha na-a mgbochi ụfọdụ megide nkụchi obi na ọrịa strok.

nhazi ọkwa

About afọ 25 gara aga, e mere naanị 8 iche iche nke NSAIDs. Taa, ọnụ ọgụgụ ahụ amụbawo ruo 15. Otú ọ dị, kpọmkwem ọnụ ọgụgụ ọbụna na-akpọ dọkịta na-e. Igosi na ahịa, ngwa ngwa ndibọhọ sirila gbasaa NSAIDs. Preparations chụpụrụ opioid analgesics. N'ihi na ha, n'adịghị ka gara aga, ọ bụghị akpasu akụkụ okuku ume na ịda mbà n'obi.

The nhazi ọkwa nke NSAIDs agụnye a nkewa abụọ dị iche iche:

1. Older ọgwụ (mbụ ọgbọ). Nke a na udi na-agụnye mara ọgwụ ọjọọ, "Tsitramon", "aspirin", "Ibuprofen", "naproxen", "Nurofen", "Voltaren", "Diklak", "diclofenac", "indomethacin", "Movimed", "Phenylbutazone" .
2. New NSAIDs (abụọ emana). Kemgbe 15-20 afọ, pharmacology azụlitewo magburu onwe ngwaahịa, dị ka "Movalis", "Nimesil", "Nise", "Celebrex" "Arcoxia."

Otú ọ dị, nke a abụghị naanị nhazi ọkwa nke NSAIDs. ọgbọ ọhụrụ ọgwụ ọjọọ eme ihe na-ekewa n'ime ndị na-abụghị acid nkwekọrịta na asịd. Ná mmalite, tụlee nke ikpeazụ Atiya:

1. Salicylates. Otu a nwere ndị NSAID ọgwụ ọjọọ, "aspirin", "diflunisal," "Lizinmonoatsetilsalitsilat".
2. Pyrazolidine. Anọchitekwa anya nke a udi nke ọgwụ ndị "phenylbutazone", "azapropazone", "oxyphenbutazone."
3. Oxicams. Nke a bụ kasị ọhụrụ ọgbọ ọhụrụ nke NSAIDs. List of ọgwụ ọjọọ: "piroxicam" "Meloxicam", "Lornoxicam", "tenoxicam." Ọgwụ na-adịghị ọnụ ala, ma ha utịp ke idem dịruru ogologo oge karịa ndị ọzọ NSAIDs.
4. Phenylacetic acid emepụta. Ndị dị otú ahụ a ìgwè nke NSAIDs agụnye pụtara "diclofenac", "tolmetin," "Indomethacin", "Etodolac", "Sulindac," "Atseklofenak".
5. Formulations anthranilic acid. Isi nnọchiteanya nke a na nkà mmụta ọgwụ "Mefenaminat".
6. N'aka propionic acid. Nke a na udi nwere ọtụtụ ndị mara mma NSAIDs. List of ọgwụ ọjọọ: "Ibuprofen" "ketoprofen" "benoxaprofen", "fenbufen," "fenoprofen," "tiaprofenic acid", "naproxen", "Flurbiprofen", "pirprofen," "nabumetone".
7. Isonicotinic acid emepụta. Main na nkà mmụta ọgwụ "Amizon".
8. pyrazolone ọgwụ ọjọọ. Iji a, Atiya bụ nke a maara nke ọma n'aka, "Analgin".

Site na-abụghị acid nkwekọrịta gụnyere sulfonamides. Nke a na-agụnye ọgwụ ọjọọ, "Rofecoxib" "Celecoxib", "Nimesulide".

mmetụta

a ọgbọ ọhụrụ nke NSAIDs e depụtara n'elu, dị iche iche dị irè mmetụta na ahu. Otú ọ dị, ha adịghị emetụta ịrụ ọrụ nke eriri afọ tract. Ọdịiche ndị a ọgwụ ọjọọ eme ihe bụ ihe ọzọ na mma ebe: ọgbọ ọhụrụ nke NSAIDs enweghị a na-agbawa obi mmetụta na cartilage anụ ahụ.

Otú ọ dị, ọbụna ndị dị otú dị irè n'aka ike akpali iche a nọmba nke ekwesighi mmetụta. Ha kwesịrị ịma, karịsịa ma ọ bụrụ na ọgwụ na-eji maka a ogologo oge.

The isi mmetụta nwere ike na-agụnye:

• dizziness;
• iro ụra;
• isi ọwụwa;
• ike ọgwụgwụ;
• obi palpitations;
• amụba mgbali;
• a obere iku ume ọkụ ọkụ;
• akọrọ ụkwara;
• digestive ọrịa;
• protein na mmamịrị;
• elu imeju enzymes;
• akpụkpọ ọkụ ọkụ (ebe);
• ọmụmụ njigide;
• anataghi.

Na nke a, gastric mucosa mmebi a na-agaghị hụrụ na nnabata nke ọhụrụ NSAIDs. The ọgwụ ọjọọ ghara ime ka exacerbation nke na-agba ọbara ọnyá afọ.

Aro maka ojiji

The kacha mma mgbochi mkpali ọgwụ ọjọọ nwere phenylacetic acid, salicylates, pirazolidony, oxicams, alkanones, ọgwụ ọjọọ nke propionic acid na sulfonamide.

Si nkwonkwo mgbu n'ụzọ kasị dị irè kpochapụ ọgwụ ọjọọ "Indomethacin", "diclofenac", "Ketoprofen", "Flurbiprofen". Nke a bụ ihe kasị mma NSAID na osteochondrosis. The n'elu ọgwụ ndị ọzọ karịa "ketoprofen" nkwadebe nwere akpọ mgbochi mkpali mmetụta. pụtara "piroxicam" na-adaba a, Atiya.

Irè analgesics bụ "Ketorolac" ọgwụ "Ketoprofen", "Indomethacin" "Diclofenac".

The ndú n'etiti ndị ọhụrụ ọgbọ nke NSAIDs bụ ọgwụ "Movalis". Ngwá ọrụ a na-kwere itinye a ogologo oge. Mgbochi mkpali ọgwụ ọjọọ ndị dị irè analogs ọgwụ ọjọọ "Movasin", "Mirloks", "Lem", "Artrozan", "Melox", "Melbek", "Mesipol" na "Amelotex".

Drug "Movalis"

A ọgwụ dị ka mbadamba, suppositories na rectal ngwọta maka intramuscular ochichi. Ukwu na-ezo aka nkwekọrịta enolovoy acid. Ji magburu onwe ọgwụ analgesic na antipyretic Njirimara. Ọ hụrụ na na fọrọ nke nta niile mkpali Filiks na nkà mmụta ọgwụ na-eweta a mmetụta bara uru.

Egosi maka ojiji nke ọgwụ ndị osteoarthritis, ankylosing spondylitis, ọrịa ogbu ogbu na nkwonkwo.

Otú ọ dị, mara na e nwere contraindications na mmadụ na-enweta:

• hypersensitivity ọ bụla akụrụngwa nke ọgwụ;
• ulcerous ọrịa na nnukwu ogbo;
• oké gbasara akụrụ impairment;
• ọnyá ọbara ọgbụgba;
• oké hepatic ọdịda;
• afọ ime, ara;
• oké obi ọdịda.

Ejila ọgwụ ụmụaka ruo 12 afọ.

Adult ọrịa a na-chọpụtara osteoarthritis, aro ya kwa ụbọchị site 7.5 mg. Ọ bụrụ na ọ dị mkpa, nke a dose nwere ike mụbara site 2 ugboro.

Na ọrịa ogbu ogbu na nkwonkwo na ankylosing spondylitis kwa norm bụ 15 mg.

Oke-elekọta ga-ọgwụ ọrịa na-ewekarị ntoputa nke mmetụta. Ndị mmadụ na-kwuputela gbasara akụrụ insufficiency na ndị na-na hemodialysis, ga-ọ dịghị ihe karịrị 7.5 mg n'ụbọchị.

The na-eri nke ọgwụ ọjọọ, "Movalis" na mbadamba nkume nke 7.5 mg, № 20 bụ 502 rubles.

Consumer echiche banyere nkà mmụta ọgwụ

Nyocha nke ọtụtụ ndị na-bụ isiokwu n'oké ihe mgbu, na-egosi na ọgwụ "Movalis" - kacha mma na ngwá ọrụ ogologo oge. Ọ na-ọma anabata ọrịa. Ke adianade do, ya ogologo ọnụnọ na ahu na-eme ka o kwe omume otu dose ọgwụ. A nnọọ mkpa, dị ka ọtụtụ ndị na-eji ọkụ, bụ iji chebe cartilage, n'ihi na ọgwụ nwere dịghị ezighị ezi mmetụta na ha. Ọ dị ezigbo mkpa ka ndị ọrịa bụ ndị na-eji n'aka na osteochondrosis, arthrosis.

Ke adianade do, ọgwụ bụ magburu onwe-azọpụta si dị iche iche ihe mgbu - mgbu, isi ọwụwa. Etinye uche pụrụ iche ọrịa na otu nnukwu ndepụta mmetụta. Mgbe na-anata ihe NSAID ọgwụgwọ n'agbanyeghị ịdọ aka ná ntị na emeputa, adịghị mgbagwoju anya wetara ya pụta.

Drug "Celecoxib"

Akparamagwa nke ngwá ọrụ a na-iji na n'ịkwụsị ihe ọnọdụ onye ọrịa na osteochondrosis na arthrosis. The ọgwụ bụ n'ụzọ zuru okè eliminates mgbu, n'ụzọ dị irè aka na aza. Oghom mmetụta na digestive usoro e kwuru.

Egosi maka ojiji e nyere na ntuziaka bụ:

• psoriatic ogbu na nkwonkwo ;
• osteoarthritis;
• ọrịa ogbu ogbu na nkwonkwo;
• ankylosing spondylitis.

Nke a Nwa nwere ọtụtụ contraindications. Ke adianade do, ọgwụ na-abụghị maka ụmụaka n'okpuru 18 afọ. Akpan akpan ịkpachara anya ga-hụrụ maka na ndị mmadụ nwere obi odida chọpụtara dị ka a n'aka nke na-amụba susceptibility ka ọmụmụ njigide.

The na-eri nke ọgwụ dịgasị dabere ngwugwu, na mpaghara nke 500-800 rubles.

n'ji uche

Oputara na-emegiderịta reviews banyere ọgwụ a. Ụfọdụ ọrịa n'ihi na nke a owuwu nwere ike merie nkwonkwo mgbu. Ọzọ ọrịa na-ekwu na ọgwụ ọ bụghị aka. N'ihi ya, nke a pụtara bụ bụghị mgbe niile irè.

Ke adianade do, anyị ekwesịghị ọgwụ onwe ha. Na ụfọdụ mba Europe a na nkà mmụta ọgwụ na-aju n'ihi na o nwere mmetụta nke cardiotoxicity, nke bụ ezuru obi njọ.

Drug "Nimesulide"

Nke a na nkà mmụta ọgwụ ọ bụghị naanị nwere mgbochi mkpali na antipain mmetụta. N'aka nwere antioxidant Njirimara na inhibit ọgwụ bekee na-ebibi cartilage na collagen emep uta eri.

Etinyere usọbọ maka:

• ogbu na nkwonkwo;
• ogbu na nkwonkwo;
• osteoarthritis;
• myalgia;
• arthralgia;
• bursitis;
• fever;
• dị iche iche na ihe mgbu ọrịamkpokọta.

Na nke a, na ịnụ ọgwụ mmetụta nke ọgwụ na-enye nnọọ ngwa ngwa. A, ọrịa na-enwe enyemaka n'ime 20 nkeji mgbe ingestion. Ọ bụ ya mere ngwá ọrụ a dị irè maka nnukwu paroxysmal mgbu.

Fọrọ nke nta mgbe, ọgwụ ọma anabata ọrịa. Ma, mgbe ụfọdụ, i nwere ike na-enwe mmetụta dị otú ahụ dị ka dizziness, iro ụra, isi ọwụwa, ọgbụgbọ, nrekasi obi, hematuria, oliguria, urticaria.

The ngwá ọrụ na-adịghị kwere na-enweta ime ndị inyom na ụmụaka ruo 12 afọ. Special elekọta kwesịrị ile ọgwụ "Nimesulide" ndị hụrụ ọbara mgbali elu, isi ọrụ nke akụrụ, ọhụụ ma ọ bụ obi.

Price ọgwụ ọjọọ na nkezi 76,9 rubles.

Gịnị na-eme na-eji ọkụ?

Nyocha nkwadebe bụ fọrọ nke nta ziri ezi mgbe nile. Ebe ọ bụ na ọgwụ ọjọọ bụ n'ụzọ zuru okè aka mgbu ma na-ebelata ahụ ọkụ, oké ọgụ mbufụt.

Ọtụtụ ndị ọrịa na-akọ na ihe mgbaàmà enyemaka emee ngwa ngwa-ezuru, na oge nke ya edinam bụ banyere awa asatọ.

Ngwá ọrụ magburu onwe n'ụzọ zuru okè eliminates ezé,-akpasasị uche, ogbu na nkwonkwo na mgbu. The ọgwụ nwere ike inyeaka erughị ala mere site akwara pụọ n'iji ụgwọ.

Drug "Ksefokam"

A ọgwụ na-esịne ke otu oxicams. Otu a nke NSAID iche ụba ọkara ndụ, n'ihi na ruo ogologo oge ọgwụ ikpughe. Ọ budata belata ugboro nke na-anata agwọ ọrịa. N'ihi ya, ihe ize ndụ nke mmetụta na-ebelata.

Drug "Ksefokam" bụ nke kasị elu ike ịnapụta ndị mgbu. Ya analgesic na mmetụta na-ike ngosipụta tụnyere morphine. Otú ọ dị, n'adịghị ka ndị ikpeazụ, ngwá ọrụ bụ na-eri ahụ na adịghị emetụta Central ụjọ usoro.

N'oge ule, ọ chọpụtara na ọgwụ aka mgbu maka 12 awa.

The na-eri nke ọgwụ na mbadamba ụdị (8 mg) № mbukota 10 bụ 205 rubles.

Drug "Rofecoxib"

The ọgwụ nwere mgbochi mkpali analgesic, antipyretic na mgbochi edematous mmetụta. E Kenyere irè n'aka maka ndị na-esonụ ọrịa:

• adịghị ala ala periarthritis;
• ọrịa ogbu ogbu na nkwonkwo;
• tendonitis;
• bursitis;
• akaị unan nke akwara, mọzụlụ.

Ọ bụ zuru ezu n'ụzọ dị irè-ewepụ ọgwụ "Rofecoxib" dịgasị iche iche nke na-egbu mgbu mgbaàmà mere site neuralgia, osteochondrosis, ikwuputa okwu Chukwu. Pụtara n'ụzọ zuru okè aka ọrịa azụ mgbu, eze mgbu, radicular syndrome.

The ọgwụ na-ekwesịghị ịbụ na isiokwu nabata site ọrịa na ụkwara ume ọkụ, mgbe ahụhụ a nkụchi obi, ọrịa strok. Ọ dịghị mkpa ka na-eji ya, na ndị na-oncological ọrịa, ọbara mgbali na atherosclerosis. The ọgwụ na-aju maka ụmụaka n'okpuru 12 afọ. Ke adianade do, tupu ị na-eji ọ bụ ihe amamihe nlezianya tụlee ekwe omume mmetụta.

Drug "Parecoxib"

Nke a bụ ihe magburu onwe ụzọ nke iji belata mkpali aziza na inye onyinye Mbelata uche nke ihe mgbu na-anabata ya. The ọgwụ bụ na ina maka ọrịa emume ịwa.

Ọ eliminates mgbu ọrịamkpokọta nke na-agafeghị oke ka oké njọ. Ndinọ mgbe ngụkọta hip na ikpere nnọchi, hysterectomy, akwara akwara wasịrị, eji na eze omume.

Ọnụọgụ ọgwụ ukpụhọde bụ kpere mmadu. Ọ na-adabere na-adakarị na ọnọdụ na-egosi. Children n'okpuru 18 afọ nke nkà mmụta ọgwụ na-bu n'obi.

Drug "Arcoxia"

The na nkà mmụta ọgwụ nwere aha ọzọ - "Etorikoksib". The n'aka e ji elu antiinflammatory, analgesic Njirimara. The nkwadebe na-akwalite mgbochi nke mgbu na-akwadoghị akwado.

Ọrịa na ọrịa nke nweekwa usoro na enyemaka nke ngwá ọrụ a tufuo ụtụtụ isi. Ha mma nkwonkwo agagharị, na-ebelata ike nke mbufụt, n'ụzọ zuru okè nyeere site mgbu. Mgbe e na ọgwụgwọ mmetụta emee n'ime iri abụọ na anọ nkeji. N'ọrụ ọgwụ umi na-ọma etinye obi gị dum site n'ọbara. The nkwadebe e ji elu bioavailability. Nke a index bụ 100%.

The dose nke ọgwụ nwere ike kenyere naanị site dọkịta. Ọ na-ejikarị àmà site 60 mg 120 mg maka ụbọchị.

The ọgwụ na-abụghị maka ojiji nke ime ndị inyom na ụmụaka ruo 16 afọ.

ọgwụgwụ

Modern pharmacology na-adịghị ada ka. Development nke ọhụrụ, irè karị NSAIDs. List of ọzọ karịa a ọgbọ ọhụrụ nke ọgwụ ọjọọ, n'elu, enye gị ohere ịhọrọ ihe kasị mma ngwá ọrụ ọ bụla pathologies. Otú ọ dị, mara na ndị ọgwụ ọjọọ na-enweghị ike ịgwọ ọrịa ahụ. Ha nwere nanị ihe mgbochi mkpali na analgesic mmetụta.