Ọtụtụ ìgwè nke ọgwụ ọjọọ - ọgwụ nje tetracycline

Tetracycline eto - na na ọ bụ a nnukwu ìgwè ọgwụ ọjọọ. Ọgwụgwọ nwere a yiri chemical Ọdịdị. Ọ ga-kwuru na ndị a na ego otu nke na-eduga n'ebe n'etiti a iche iche sara mbara nke ọrụ nke ọgwụ ọjọọ.

Tetracycline ọgwụ nje. nkọwa

Drugs na otu a ha nwee nkụda mmụọ na mmeputakwa na mmepe nke gram-adịghị mma, gram-mma bacteria, ruo (nke acid), nnukwu nje, ndị ọzọ bacteria. Na udi na-agụnye ọgwụ ndị dị otú ahụ dị ka "chlortetracycline hydrochloride", "Oxytetracycline hydrochloride", "Tetracycline" na ndị ọzọ. Drug ọmụmụ malitere na 1948. Ruru ụfọdụ ihe isi ike na-na sịntetik ọgwụ ọjọọ nke taa na-kere iji biosynthesis. All tetracycline ọgwụ nje dị iche amphoteric agwa. Ha bụ isi àgwà n'ihi dimethylamino otu. Ya ọgwụ igosipụta acidic Njirimara n'ihi na phenolic hydroxyl nke D-mgbanaka. Dị ka ihe amphoteric compound soluble na acid na alkali, akpụ nnu. Ha, n'aka hydrolyzed na okenye agbanwe agbanwe. Elu etoju na-egbochi acid hydrolysis usoro, na ọdịda isi ịkpali.

All tetracycline ogige nwere spektra ahụ yiri onye ọ bụla ọzọ. Na ụmụ irighiri nke phenolic hydroxyl akpata agba mgbanwe site mmeghachi omume na ferric chloride (3). Tetracycline ọgwụ nje na-amalite irekasị etolite alkali izotetratsiklinov. N'aka nke ya, nke a na-esonyere a uru na eserese. general mmeghachi omume e ji mara ndị niile tetracycline ogige. Preparations iche onye ọ bụla ọzọ bụ na o kwere omume ekele dị iche iche staining n'okpuru nduzi nke na igirigi ibu sulphuric acid (lekwasị). Nke a na-esonyere guzobe ogige, acha maka nke ọ bụla tetracycline na ya na agba. Ya mere, ihe atụ, na onye e nwere a-acha odo odo-acha ọbara ọbara hue, ọzọ - acha odo odo. Otu n'ime ihe ndị e ji mara na-atụle ga ọgwụ ike fluoresce n'okpuru nduzi nke UV ìhè. Ọ bụ mgbe eji dị ka ihe àmà nke ịbụ eziokwu ha.

Pharmacological Njirimara tetracycline

Nke a nkwadebe dị iche zuru ezu iche iche sara mbara nke ọrụ. Ya bacteriostatic mmetụta bụ n'ihi na mgbochi nke protein njikọ causative bacteria. ọgwụ ọrụ na-egosi ikwu aerobic gram-mma bacteria, gụnyere ụdị amị penicillinase. The ọgwụ na-emetụta gram-adịghị mma bacteria. Ngosi ọgwụ na-eguzogide obere nje, ọtụtụ dịkwa ka usoro ha na a ọnụ ọgụgụ nke ndị ọzọ pụta.

Ụfọdụ ọgwụ nje mbanye iwu. oghom Jeremaya mere

Ọ na-atụ aro iji ọgwụ ọjọọ eme na a dose nke 0.3 grams nke mbụ na nke abụọ ụbọchị, 0,2 grams nke ugboro ise na-esonụ ụbọchị. Gonorrhea (subacute na nnukwu-adịghị mgbagwoju) na N'ezie kenyere 5 g, na ndị ọzọ forms - 10. Ọ na-atụ aro na-na nkà mmụta ọgwụ tupu ma ọ bụ n'oge nri. Against ndabere nke kwesiri ewe iwe afo, vomiting, ọgbụgbọ.