Protamine sulfate: Description na User

Gịnị bụ ọgwụ umi dị ka protamine sulfate? ntuziaka maka ojiji, nakwa dị ka na udi ma na ihe àmà nke ego ga-depụtara n'okpuru.

Mejupụtara, nkọwa, ụdị

Gịnị bụ protamine sulfate? Nke a ngwọta e atara ka a acha ma ọ bụ colorless uzo mmiri mmiri zubere maka igba ogwu n'akwara ochichi. The nkwadebe dabeere na a ọgwụ nwere otu aha, na n'ihu mejupụtara a mmiri ogwu ogbugba.

Na ire "Protamine sulfate" na-ọnọ na vials na-enịm na cell ndepụta si polyvinyl chloride film, nke na-juru n'ọnụ ke katọn. Ọzọkwa ke ngwugwu na-etinye ntuziaka maka ojiji na ampoule opener.

Drug edinam

Gịnị bụ protamine sulfate? Guide na-akọ na a heparin eti ọkpọ (kpọmkwem). 1 mg nke umi ike iche na ọrịa ọbara banyere 80-115 IU nke heparin.

Action akuko pụtara mgbe igba ogwu n'akwara ọgwụ amalite ozugbo na-ewe ihe dị ka awa abụọ. Complexation nke ọgwụ n'ihi ụba nke cationic iche iche na-eke agbụ na anionic emmepe heparin.

Dị ka ntụziaka nke protamine sulfate na ụmụ mmadụ na-complexed heparin-protamine, nke etịbede nyak ikpeazụ.

Na ovadozu nke a pụtara a ndidi nwere ike budata belata ọbara clotting, ebe ewere nọ n'ọrụ gị n'ụlọnga Nwa-egosipụta a elu anticoagulant ọrụ.

Pharmacokinetics n'aka

Gịnị nwere kinetic Njirimara nke heparin protamine sulfate? Dị ka ndị ọkachamara, ọ nwere pharmacokinetic Njirimara nke ọgwụ adịghị mụọ. Ya mere, ha na-adịghị na-anọchi anya na ntuziaka.

Egosi maka ihe ngwọta

Mgbe ụfọdụ, ọrịa igba ogwu n'akwara ngwọta "Protamine sulfate" nwere ike na-kenyere? Ngwa nke a pụtara na-egosi:

• tupu ịwa ahụ na ndị na-ewere heparin maka ọgwụgwọ nzube;
• na hyperheparinemia;
• maka agba ọbara na-ewere ọnọdụ n'ihi heparin ovadozu;
• mgbe ọrụ na ọbara arịa na obi extracorporeal mgbasa.

Ukpan ka ebe ngwọta

Drug "Protamine sulfate" (a ọgwụ ịzụta ya ga nye iwu a dọkịta) na-contraindicated na-esonụ mgbe:

• na thrombocytopenia;
• elu uche na ndị ọcha nke ọgwụ;
• oké hypotension;
• congenital ma ọ bụ mgbawa hyperheparinemia (na steeti a na ọgwụ bụ adighi ike, na ike budata welie ọbara ọgbụgba);
• ochichi nke insulin na ndị ọzọ ọgwụ ọjọọ nwere a protamine sulfate;
• nfụkasị Jeremaya azu na ngwaahịa, tinyere a akụkọ ihe mere eme;
• adrenal insufficiency.

Anyị nwere ike ikwu na ahụmahụ nke ọgwụ na ahụ ike iji ngwá ọrụ a na ụmụ bụ nanị.

N'oge ime na lactation "Protamine sulfate" nwere ike ji mee. Otú ọ dị, nke a ga-eme naanị na ikpe, ma ọ bụrụ na mmetụta nke ọgwụgwọ bụ budata elu karịa kwesiri ize ndụ iji nwa ebu n'afọ ma ọ bụ nwa.

Nkwadebe "Protamine sulfate": ntuziaka maka ojiji

E lee ya anya ngwọta ga-ndinọ site ngwa ngwa IV ntapu ma ọ bụ bolus. N'ihi ya na ọnụego nke ochichi ekwesịghị gafere 5 mg kwa nkeji. Ọsọ ọsọ iwebata ọgwụ nwere ike ime ka onye ọrịa anaphylactoid mmeghachi omume.

Onunu ogwu nke agwọ ọrịa na-adabere na usoro nke ochichi. The gbakọọ dose ga-etisasịwo ke 300-500 ml nke 0,9% ike sodium chloride ngwọta. Ọ na-machibidoro tinye ihe karịrị 150 mg nke ọgwụ maka 60 nkeji.

• Na bolus injection onunu ogwu nke protamine sulfate na-ebelata dabere na oge na agafeela si ochichi nke heparin. Nke a bụ n'ihi na eziokwu na nke ikpeazụ na-nọgidere wepụrụ ahụ mmadụ.
• Ọ bụrụ na heparin na-ndinọ igba ogwu n'akwara ntapu, ọ dị mkpa ka a kwụsị infusion na-eji ihe 20-30 mg nke protamine sulfate.
• Mgbe subcutaneous ntụtụ heparin onunu ogwu nke protamine sulfate 1-1.5 mg 100 IU heparin. N'ihi ya mbụ 25-50 mg a ga-nwayọọ nwayọọ ndinọ intravenously, na ndị fọdụrụ ibu - igba ogwu n'akwara ntapu maka 8-17 awa. Ọ dịkwa ike intermittent ochichi, ma ọ ga-achọ ike nlekota nke APTT.
• Mgbe a ozugbo aka bụrụ na nke extracorporeal mgbasa ngwọta na-ewere onunu ogwu bụ 1.5 mg 100 ME heparin.

The kacha oge nke ọgwụ nke ego bụ 3 ụbọchị.

Action by-agwa

Nwere ike na-protamine sulfate ime ka oghom Jeremaya mere? Manual na-ekwu na n'ozuzu a ọgwụ na-dịtụ ọma anabata ọrịa. Otú ọ dị, mgbe ụfọdụ, ọ ka nwere ike ime ka oghom mmetụta na akụkụ nke dịghịzi, obi na digestive usoro, nakwa dị ka anụ ahụ:

• bradycardia, a gụnyere ya ná ọbara mgbali;
• vomiting na ọgbụgbọ;
• itching, anụ ọkụ ọkụ, mmepe nke anaphylactoid Jeremaya mere;
• mmetụta na-ekpo ọkụ, na-eche mkpụmkpụ nke ume, na flushing nke anụ.

Overdoses na na mmekọrịta ndị ọzọ ọgwụ ọjọọ eme ihe

E lee ya anya ngwọta zubere maka igba ogwu n'akwara ochichi ekwekọghị penicillins na cephalosporins. Nyere na ọ bụ ihe na-eti ọkpọ, ala molekụla ibu heparins, ifịk ọgwụ pụrụ ịmụba oge na ike nke ihe nke na-abụghị depolarizing muscle relaxants.

An ovadozu nke ọgwụ ike ga-metụtara ọbara ọgbụgba. Nke a bụ n'ihi na eziokwu na umi na ajụjụ nwere nnukwu anticoagulant ọrụ. Na nke a, na-arụ symptomatic ọgwụgwọ a chọrọ.

kpọmkwem ozi

Ihe i kwesịrị ịma tupu ị banye dị otú ahụ a ngwọta dị ka protamine sulfate? Ọkachamara na-ekwu na nke a ọgwụ ga-anya ekwu site a dọkịta onye ga-ahụ mgbe nile nyochaa ọbara clotting ndidi.

Tupu mmeghe nke ọgwụ mkpa iji hụ na ezigbo ọrịa ọbara olu. Nke a bụ n'ihi na eziokwu na hypovolemia budata enwekwu ihe ize ndụ nke ida.

Nchekwa ọnọdụ nke ọkọnọ nke pharmacies, adị ndụ

Ma unu kpamkpam na-ere pharmacies ọgwụ ọjọọ, "Protamine sulfate '? Ntụziaka na Latin ma ọ bụ Russian asụsụ, jide n'aka na-egosi na ọgwụ, ma ọ bụghị ọgwụ a tọhapụrụ.

Ịchekwa n'aka atụle mkpa apụghị iru nke ụmụaka na-echebe site na ìhè anyanwụ ebe ikuku okpomọkụ bụ n'etiti 4 na 10 degrees. Ọ kwesịkwara kwuru na igba ogwu n'akwara ngwọta "Protamine sulfate" ihe ọ bụla ikpe agaghị oyi kpọnwụrụ.

Adị ndụ nke a ọgwụ bụ 4 afọ si ụbọchị nke rụpụta. Unu na-eji ya n'ofè ngafe nke oge a.

Drug analogues na reviews banyere ya

Analogues na akuko ngwaọrụ adịghị nnọọ ọtụtụ. The igba ogwu n'akwara ngwọta e nwere ike dochie anya ọgwụ ọjọọ ndị dị ka "Protamine" na "Protamine-Verein".

Gbasara n'ji reviews, ọ fọrọ nke nta ha niile bụ ndị ziri ezi. "Protamine sulfate" - nke a bụ nnọọ oru oma na irè n'aka onye ọ bụla nwere. Ọ na-a echiche na-akọrọ ndị ka n'ọnụ ọgụgụ nke ndị ọrịa. Ha na-ekwu na nke a ọgwụ adịghị enye heparin ibelata usoro ọbara clotting, rụọ ọrịa na-arịa n'oge arọ ọbara ọgbụgba.

Dị ka kpọkwara a ọgwụ na-agụnye ya ngwangwa ma ruo ogologo oge mmetụta. Ọzọkwa, na-enweta a ọgwụgwọ mmetụta ka onye ọrịa na-chọrọ na-ebu ogologo oge ọgwụgwọ. The kacha oge nke eji nke a ọgwụ bụ ụbọchị atọ.