"Zanidip": ntuziaka maka ojiji, n'ezie na ọrịa na dọkịta ogbo. "Zanidip-Rekordati": ndu, reviews, analogs

Dị ka ọnụ ọgụgụ, banyere 26% nke ndị toworo eto na ụwa na-ata ahụhụ site na ọbara mgbali elu mgbe nile. Ọtụtụ mgbe a na ọrịa a na-ejikọta ya na mkpụrụ ndụ ihe nketa pụrụ ịrịa. Otú ọ dị, e nwere ihe ndị ọzọ n'ihi na ya na omume. A na-agụnye oké ibu, ise siga, oké oriri nke nnu, enweghị Chọpụta ọcha na vitamin ke idem, ịṅụbiga mmanya ókè, nchegbu, ala emega ahụ, na ndị ọzọ.

Ọ kwesịkwara kwuru na mmepe nke ọbara mgbali na-adabere na onye afọ. The okenye ọ bụ, elu n'ihe ize ndụ nke dị otú ahụ a-enweghị nchịkwa na ala. Mgbe ọ dị afọ 40 afọ, ọrịa bụ fọrọ nke nta mgbe n'ihi sclerotic vaskụla ọnya.

ozi izugbe

Ọtụtụ mgbe, ndị dọkịta na-etinye ha na-agwọ nchoputa "oké mkpa ọbara mgbali". Gịnị ka ọ bụ? Ọ bụ a-adịghị ala ala ọrịa na a ụdị ọbara mgbali. Ya isi na-adakarị mgbaàmà eme persistent ruo ogologo oge elu nke ọbara mgbali.

Mgbanwe dị otú ahụ na ọrịa nwere ike dị iche iche. Otú ọ dị, ha bụ isi metụtara ọbara arịa na obi.

Iji mma ọrịa na-arịa, ndị dọkịta nwere ike ikwu na a ọgwụ dị ka "Zanidip". Nyocha nke ọrịa na ịdị irè nke ọgwụ ga-atụle ihe ndị a n'isiokwu a. Ọzọkwa n'ebe ahụ ka ị ga-ahụ ihe ọmụma banyere otú na-enweta si ọgwụ, ma ọ bụrụ na o nwere ọ bụla analogues na mmetụta.

Description, mejupụtara, na udi ma na nkwakọ

The agwọ ọrịa "Zanidip" ntụziaka na-echekwara na a katọn ùkwù atara n'ụdị mbadamba ìhè odo na gburugburu na biconvex forms a akara na otu nke n'akụkụ. Ha bụ film-ntekwasa na nwere a acha tint na ezumike.

The n'ọrụ mgwa nke a ọgwụ eme lercanidipine hydrochloride. Ọzọkwa, ọ na-agụnye na inyeaka mmiri, nke na-anọchi anya dị ka povidone K30, lactose monohydrate, sodium carboxymethyl starch, microcrystalline cellulose na magnesium stearate.

Banyere film-mkpuchi Nwa, mgbe ahụ, ọ na-emi esịnede bekee ndị dị otú ahụ dị ka Opadry Yellow, talc, hypromellose, titanium dioxide, ígwè oxide odo e ji esiji ákwà na macrogol 6000.

Zụrụ "Zanidip" mkpụrụ ọgwụ na ọnya ngwugwu nwere ike, na-enịm ke akwụkwọ igbe.

Pharmacological e ji mara ọgwụ

Ị maara na bụ ọgwụ "Zanidip"? Ntuziaka na ngwa na-egosi na ọ bụ a calcium ọwa blocker ngwa ngwa. Ya n'ọrụ mgwa ihe bụ a racemic ngwakọta nke dextro-na levorotatory stereoisomers. Ọ ga na-ahụ kwuru na ọ bụ a emepụta nke 1,4-dihydropyridine.

Nke a agwọ ọrịa bibiri igbochi ugbu a nke calcium ion n'ime gbasara obi sel, vaskụla mkpụrụ ndụ na-eji ire ụtọ muscle.

Ụkpụrụ nke nyere antihypertensive mmetụta nke ọgwụ bụ n'ihi na a kpọmkwem relaxant mmetụta vaskụla ezigbo muscle mkpụrụ ndụ.

Dị ka ntụziaka, mgbe ha natasịrị a ọgwụgwọ mmetụta nke agwọ ọrịa a na-enweta mgbe 5-7 awa. Na oge nke ya ndaba na-nọgidere na-enwe ihe n'ụbọchị ahụ.

Ruru akwa selectivity nke ọgwụ na vaskụla ezigbo muscle mkpụrụ ndụ, ọ dịghị nwere adịghị mma inotropic mmetụta.

N'ihi ya, ihe a ọgwụ ọjọọ, "Zanidip-Rekordati"? Guide na-ekwu na ọ bụ metabolically-anọpụ iche na-agwọ nke na-adịghị nwere ọtụtụ mmetụta na ọdịnaya nke apolipoproteins na lipoproteins na ọbara ọbara, nakwa dị ka adịghị agbanwe profaịlụ nke mara abụba na ndị na ọbara mgbali.

The kinetics nke ọgwụ

Ebe etinye obi gị dum ọgwụ "Zanidip"? Ntuziaka maka ojiji ga-agwa anyị na mgbe na-anata mbadamba (10 ma ọ bụ 20 mg) n'ime lercanidipine fọrọ nke nta kpamkpam etinye obi gị dum na eriri afọ tract. Mgbe 1.5-3 awa kacha ịta nke ọgwụ na ọbara plasma esịmde a uru nke 3.3 and / ml ma ọ bụ 7,66 and / ml karị.

The nkesa nke ọgwụ na nsụkọrọ na akụkụ-ewe ebe nnọọ ngwa ngwa. Communication na plasma-edozi karịa 98%. Ugboro ugboro dose mbadamba ha ìgwè a hụrụ.

The metabolism nke ọgwụ a rụrụ n'oge mbụ ngafe site imeju. Na nke a emee site biotransformation CYP3A4. Nke a na-emepụta a ọnụ ọgụgụ nke metabolites na nke enweghị pharmacological ọrụ.

Egosipụta na nkà mmụta ọgwụ "Zanidip", reviews nke nke na-n'ihu ubé ala site na eriri afọ na akụrụ. E nwere ihe abụọ n'ụzọ mwepụ nke lercanidipine: n'oge onye oge 2-5 awa na ikpeazụ - 8-10 awa.

The na-agbanweghi agbanwe ọgwụ na-fọrọ chọpụtaghị na na nsị na mmamịrị.

Ndị na-imeju ma ọ bụ gbasara akụrụ ọrịa protein ọdịnaya nke plasma na-budata belata. Na nke a, na free nta nke nọ n'ọrụ umi nke agwọ ọrịa nwere ike n'ụzọ ụba.

Egosi na-enweta ọgwụ

N'ihi nzube dị aṅaa nwere ike kenyere ọgwụ "Zanidip"? Nyocha nke dọkịta kọrọ na a gị n'ụlọnga irè na-egosipụta onwe ya na oké mkpa ọbara mgbali na nke dị nwayọọ na agafeghị oke ntaramahụhụ.

Contraindications na-enweta ndị mbadamba

Dị ka ntụziaka, ọgwụ "Zanidip" kwesịghị iwere n'okpuru ndị na-esonụ ọnọdụ:

• oké imeju ọrụ;
• ala ala obi odida uwa (karịsịa decompensation nzọụkwụ);
• isi gbasara akụrụ ọrụ;
• ejighị n'aka rịaworo ;
• Nchikota na ike inhibitors isoenzyme CYP3A4 (atụ, "ketoconazole", "erythromycins", "itraconazole") na "cyclosporin" na mmiri grape;
• n'oge ime;
• mgbochi nke ọbara arịa na-abịa site n'aka ekpe ventricle nke obi;
• lactose ekweghị ibe nọrọ, lactase ụkọ na malabsorption syndrome galactose / glucose;
• n'oge ara;
• na nso nso site myocardial infarction (n'oge oge nke otu ọnwa);
• Women ịmụ nwa, nwa afọ ndị na-adịghị eji a pụrụ ịdabere na-esi n'aka igbochi afọ;
• n'okpuru afo (nrụpụta na nchekwa na-adịghị a guzosie ike);
• hypersensitivity ka lercanidipine na ndị ọzọ na dihydropyridine nkwekọrịta ma ọ bụ ọ bụla mmiri nke ọgwụ.

Akọ na-ewere ọgwụ

The agwọ ọrịa "Zanidip-Rekordati" ịkpachara anya na-atụ aro na-ndị mmadụ na mkpọchị imeju ọrụ (agafeghị oke, nke dịkwa nwayọọ), ala ala obi nedostatochnostyusindromom imi, ekpe ventricular odida na akwara akwara ọrịa, na na n'otu oge n'ikuku "Digoxin" beta-blockers.

Mbadamba "Zanidip": ntuziaka maka ojiji

Na echiche nke ukwuu nke oghom ihe na-atụle ọgwụ ga-ndinọ site ahụmahụ anya. A, ifịk ọgwụ na-atụ aro iji na-ego nke 10 mg otu ugboro n'ụbọchị.

Mkpụrụ ọgwụ a ga-rụrụ ke usenubọk, maka ¼ hour tupu nri ụtụtụ.

Dabere na ọgwụgwọ mmetụta nke usoro onunu ogwu nke ọgwụ n'okpuru echiche nwere ike okpukpu abụọ, i.e. na banyere 20 mg. Ịba doses nke agwọ ọrịa ga-erukwa nwayọọ nwayọọ. Ọ bụrụ na chọrọ, na-abawanye na ego nke agwọ ọrịa rụrụ mgbe izu abụọ mgbe mmalite nke ọgwụ.

Olee otú m ga-ewe "Zanidip-Rekordati"? Ekwela ata mbadamba nkume. Ha na-ejikarị loro na asa ala na a zuru ezu ego nke mmiri mmiri.

Ndị agadi No onunu ogwu ukpụhọde a chọrọ. Ma mgbe na-ewere ọgwụ maka ọnọdụ ha na-achọ mgbe nile nlekota oru.

Na ọnụnọ nke hepatic ma ọ bụ gbasara akụrụ odida ma ọ bụ agafeghị oke ogo onunu ogwu mgbazi bụ chọrọ. Ke akpa ụbọchị ole na ole nke ọgwụ ndinọ ke ichekwa 10 mg, na mgbe ahụ na-elezi anya na-amụba dose 20 mg kwa ụbọchị.

Ọ bụrụ na ndị antihypertensive mmetụta ike kwuru na, kpọmkwem usoro onunu ogwu na-ebelata.

mmetụta

Nwere ike ime ka na-achọghị Jeremaya mere "Zanidip-Rekordati"? Consumer reviews agwa na oriri nke a pụtara na ha na-apụta mmetụta. Gịnị kpọmkwem, anyị na-atụle ugbu a:

• Dịghịzi usoro: Hypersensitivity.
• Obi usoro: tachycardia, rịaworo, palpitations, na-ada mbà, flushing na ihu anụ ahụ, obi mgbu, akara Mbelata ke ọbara mgbali, obi ọgụ.
• Ụjọ usoro: somnolence, isi ọwụwa, dizziness.
• Digestive tract: vomiting, dyspepsia, ọgbụgbọ, reversible abawanye na imeju enzymes, afọ ọsịsa na abdominal mgbu.
• Skin ọkụ ọkụ.
• Nweekwa usoro: myalgia.
• Urinary: polyuria.
• Ndị ọzọ: elu edema, ike ọgwụgwụ, gingival hyperplasia, ike ọgwụgwụ.

Mgbaàmà nke ovadozu

Gịnị mmetụta ga-eso, ma ọ bụrụ na ị na-elu doses nke ọgwụ "Zanidip"? Guide depụtara ndị na-esonụ mgbaàmà nke ovadozu: myocardial infarction, mpiaji tachycardia, elu vasodilation na nnọọ ọnụ ke ọbara mgbali, na-abawanye na ndị oge na ugboro ole nke rịaworo ọgụ.

Iji kpochapụ ndị dị otú ahụ na-ekwu, symptomatic ọgwụgwọ.

ọgwụ interactions

Ọ ga-ekwe omume na ikpokọta na ọgwụ ọjọọ ndị ọzọ na nkà mmụta ọgwụ "Zanidip"? Ntuziaka maka ojiji na-egosi na ngwá ọrụ a machibidoro iwu ikpokọta dị otú ahụ na inhibitors CYP3A4 (cytochrome P450 nke imeju), dị ka "Itraconazole" "ketoconazole" na "erythromycin". Nke a bụ n'ihi na eziokwu na ihe niile ọgwụ ndị a dịkwuo ịta nke lercanidipine n'ime ọbara, nakwa dị ka ụzọ na antihypertensive mmetụta.

Imekotaotuugbo n'ikuku akuko pụtara "cyclosporin" na-contraindicated, dị ka ọ pụrụ iduga na-abawanye na ọdịnaya nke ma bekee na a ọrịa ọbara.

Lercanidipine na-aju ga-eji ọnụ na mmiri grape. A pụrụ ịkpata potentiation nke antihypertensive mmetụta nke lercanidipine na mgbochi nke metabolism.

Ọ ga-egosipụta oké ịkpachara anya mgbe na-anata "Zanidipa" dị otú ahụ ọgwụ ọjọọ eme ihe dị ka "Astemizole", "Terfenadine" na "quinidine", na-antiarrhythmics nke klas nke atọ (e.g., "Amiodarone").

The Nchikota nke atụle agwọ ọrịa na anticonvulsant ọgwụ ọjọọ ( "phenytoin," Carbamazepine ") na" rifamycins "nwere ike na-eme ka Mbelata ke ọbara etoju nke lercanidipine, dapụtara na ọnụ nke antihypertensive mmetụta nke lercanidipine.

Mgbe ọgwụ Nchikota na "Digoxin" kwesịrị nọgidere nyochaa ihe ịrịba ama nke igbu egbu.

Imekotaotuugbo ọgwụgwọ na agwọ ọrịa "midazolam" toro pụrụ ịmụba absorbability nke lercanidipine na belata ya absorption ọnụego.

Ọkachamara na-ekwu na "metoprolol" bụ ike nke na mbenata bioavailability nke lercanidipine 50%. Na nke a, na bioavailability nke "Metoprolol" na-anọgide na-agbanweghi agbanwe. Nke a pụrụ isi kwuo ya na-ebilite si ọnụ ke hepatic ọbara mere site beta-blockers.

Nkwadebe "Cimetidine" na a onunu ogwu nke 800 mg kwa ụbọchị na-adịghị eme na ịrịba mgbanwe ọbara ịta nke lercanidipine. Ma na ya n'ikuku chọrọ pụrụ iche ịkpachara anya, ebe ọ bụ na elu doses pụrụ ịmụba bioavailability nke lercanidipine na N'ihi ntọt ya antihypertensive mmetụta.

Na Nchikota "Zanidipa" na "Simvastatin" akpa ọgwụ ka a ụtụtụ, na nke abụọ - na mgbede.

The agwọ ọrịa "fluoxetine" enweghị mmetụta na kinetics nke lercanidipine.

Imekotaotuugbo n'ikuku "Zanidipa" na "warfarin" ahụ emetụtaghị pharmacokinetics nke ikpeazụ.

Of ego nwere ike ikpokọta na diuretics, beta-blockers na Ace inhibitors.

Anyị ga na-ekwukwa na ethanol enhances antihypertensive mmetụta lekarnidipina.

kpọmkwem na-atụ aro

Drug "Zanidip", analogues nke nke na-depụtara n'okpuru ebe a, kwesịrị ihe ókè ịkpachara anya na ndị mmadụ na isi ọrụ nke akụrụ na akwara akwara ọrịa, dị ka nke a, e nwere oké ihe ize ndụ nke mụbara ugboro ole nke rịaworo ọgụ.

Tupu na-anata ọgwụ mgbe niile kwesịrị-ahụ ụgwọ atụrụ obi ọdịda a-adịghị ala ala uwa.

Akpan akpan ịkpachara anya ga-hụrụ ná mmalite nke ọrịa, karịsịa na ọrịa na-agafeghị oke, nke dịkwa nwayọọ ogo hepatic insufficiency.

N'oge ọgwụgwọ, ọ na-achọsi ike nlezianya mepụta ọrụ chọrọ nlebara anya pụrụ iche, gụnyere na ụzọ management. Nke a bụ n'ihi na eziokwu na ná mmalite nke ọgwụ na na ngafe doses e nwere ihe ize ndụ nke omume nke isi ọwụwa, iro ụra na dizziness.

nchekwa ọnọdụ, adị ndụ nke nkwadebe na ire

Ebe m nwere ike ịzụta mkpụrụ ọgwụ "Zanidip-Rekordati"? Analogs nke ego onwe ya ọgwụ na-ere ihe ọ bụla na-ere ọgwụ. Otú ọ dị, ha nwere ike zụrụ nanị na ndenye ọgwụ nke dọkịta.

Na-a na nkà mmụta ọgwụ nke iru-achọsi ike na-eto eto ụmụ ebe okpomọkụ adịghị gafere 30 degrees.

Adị ndụ nke ọgwụ n'okpuru echiche bụ afọ atọ. Mgbe oge a, na-ewere ọgwụ na-aju.

ọgwụ analogues

Ị maara ihe ị nwere ike dochie mkpụrụ ọgwụ "Zanidip"? Analogues nke ngwá ọrụ a bụ nnọọ ike iji chọta. Ndị ọkachamara na-na-akọ na yiri Njirimara na ọrụ nke ndị dị otú ahụ preparations nweta dị ka "Lerkamen" na "Lercanidipine". Inweta ọgwụ ndị a ga na-enwe maka ọgwụ ndụmọdụ.

Drug "Zanidip": reviews nke ọrịa na ndị ọkachamara

Ọ bụ nnọọ irè antihypertensive n'ụlọnga. Nke a na-ele na-akọrọ site ọtụtụ ndị dọkịta. Anyị na-ekweta na ha, na fọrọ nke nta niile ndị ọrịa na-ewere ọgwụ "Zanidip". Ha na-ekwu na mgbe na-ewere ọgwụ na ọnọdụ ha ịrịba mma. Ihe ịrịba ama nke dị oké mkpa ọbara mgbali dị nwayọọ na agafeghị oke ogo ahapụ fọrọ nke nta ozugbo.

The naanị drawback nke a ọgwụ bụ na-ewere ya nnọọ na-akpatakarị mmetụta, karịsịa na akụkụ nke digestive tract na obi usoro.

Ọ kwesịkwara kwuru na ọtụtụ ndị na-eme mkpesa banyere price nke ọgwụ dị elu. A ọgwụ bụ na ego nke 28 mbadamba nwere ike zụta maka 450-500 rubles. Ọ ga-kwuru na analogues nke si agwọ ọrịa n'ụdị "Lerkamena" na "lercanidipine" mere abụghị ọnụ ala karịa. Ha nwere ike zụrụ maka otu price.

Ọkachamara na-ekwu na ndị na-eri "Zanidip" antihypertensive ọgwụ n'ụzọ zuru ezu complies na ya mma. Ọ na-egosi fọrọ nke nta dum nke ya ogologo ahụmahụ na-ngwa.