Zoledronic acid: pharmacological mmetụta na analogues

Ọ maara na bisphosphonates agbasaghị inhibit mmepe nke ọkpụkpụ metastasis gbochie ọkpụkpụ ọnwụ. Onye nke kasị mma ọgwụ ọjọọ nke otu a - zoledronic acid. Ọzọkwa, e nwere ihe gosiri na nke a ọgwụ ọjọọ nwere angioneogenesis mgbochi, akpụ mbuso agha, adhesion nke akpụ mkpụrụ ndụ na ọkpụkpụ anụ ahụ, induces apoptosis, na e nwere Synergy na-anara ọgwụ.

Nwa 1 Vial

Zoledronic acid monohydrate - 4,26 mg Excipients - sodium citrate, D-mannitol.

pharmacology

An inhibitor nke ọkpụkpụ resorption. Zoledronic acid bụ nke a ọhụrụ na klas nke elu klas nke bisphosphonates. Ọ nwere a nhọrọ utịp ke ọkpụkpụ. Ebelata ọrụ nke osteoclasts, enweghị na-eme a na-ezighị ezi pụrụ isi kwuo na e guzobere na àgwà ndị ọzọ nke ọkpụkpụ anụ ahụ. Mmetụta nke bisphosphonates na ọkpụkpụ na-dabeere na a elu kweta mineralized ọkpụkpụ, ma kpọmkwem usoro nke ụmụ irighiri ihe na-enye inhibiting ọrụ nke osteoclasts, ta ka bụghị e mụọ. Ọzọkwa ya nwere a kpọmkwem mgbochi akpụ Njirimara, huu arụmọrụ ke ọkpụkpụ metastasis.

Na vitro hụrụ na zoledronic acid, induces apoptosis na inhibiting proliferation nke mkpụrụ ndụ na-enwe otu antitumor mmetụta na na myeloma, nakwa dị ka na ndụ nke kansa nke ara, mgbe mbenata ihe ize ndụ nke metastasis. Ọzọkwa, zoledronic acid nwere a onwunwe nke mbenata calcium ịta na ọbara hypercalcemia, nke e mere site a ngwọta.

egosi

• Osteolytic ọnya na otutu myeloma foci.
• Osteoblastic, osteolytic mbuaha ọkpụkpụ metastasis nke nnukwu etuto ahụ.
• Hypercalcemia, nke e mere site malignancy.

contraindications

• Pregnancy na ara.
• Gbasara akụrụ insufficiency.
• Ụmụaka na-eto eto (ngwa nche ka e guzosie ike).
• Hypersensitivity ka bisphosphonates na zoledronic acid.
• Anya: gbasara akụrụ dysfunction, bronchial ụkwara ume ọkụ, hepatic ọdịda.

mmetụta

Anaemia, thrombocytopenia, isi ọwụwa, dizziness, conjunctivitis, ọgbụgbọ, anorexia, vomiting, afọ ọsịsa, ọkpụkpụ mgbu, arthralgia, hypophosphatemia, hypocalcemia, fever, flu syndrome, ike ọgwụgwụ, ibu ibu. Na ọgwụgwọ nke ọrịa na zoledronic acid mgbe ụfọdụ hụrụ mmepe nke osteonecrosis nke n'agba (na-emekarị mgbe eze ịwa ahụ aka).

dosing

Igba ogwu n'akwara ntapu, na n'ime minit 15, ma ọ na-erughị. Metastases nke multiple myeloma na-atụ aro dose nke 4 mg ugboro n'ọnwa. Mgbe hypercalcemia, nke e mere site a ịza aza akpụ, a dose of 4 mg ugboro kwa ụbọchị.

adọ aka ná ntị

Ozugbo ọgwụ ndinọ, ọ dị mkpa ịchịkwa ịta nke magnesium, site, creatinine na calcium na ọbara ọbara. Ọ bụrụ na o kwere omume, ọ na-atụ aro iji zere eze n'ịwa ahụ.

Zoledronic acid. analogs

Drugs "Actonel", "Aneldronat", "Areda lyophilisate", "Bonviva", "Bondronat", "Bonefos", "Klobir", "ksidifon", "Lindron", "Ostalon", "Ostealen", "Osterepar" "Pamidronate", "Pomegara", "Rizendros", "Strongos", "Tevanat", "Foroza" "Fosamax", "Fosfoteh", "Rizarteva".

Zoledronic acid. price

A, saịtị abuana ke nkesa nke ọgwụ na iwu, na-egosi ndị ahịa maka ngwá ahịa ha. Ma, oddly ezu, ego nke zoledronic acid a na-emekarị gosiri ihe. Ma ịgụta ya uru esịmde banyere 14 puku rubles kwa karama. Ere pharmacies site ọgwụ naanị.

The n'elu ozi ezubere mara ike ọrụ. Isiokwu a bụ banyere zoledronic acid anaghị dochie ruru eru ndụmọdụ nke a dọkịta, na-apụghị inye a nkwa nke a mmetụta dị mma site n'iji ọgwụ.