"Dopamine" - ihe bụ ihe ahụ? "Dopamine": ntụziaka, ngwa, price

Ọgwụ "dopamine" anya dị ka a crystalline ntụ ntụ nke na-acha ọcha na agba na a sonso nke nganu uche isi nke hydrochloric acid. Nke a na ụdị ya nwere n'ụdị hydrochloride. "Dopamine" - a umi soluble na mmiri na mmanya. Ọ na-emetụta alkalis, iche iche oxidizing mmadụ na ígwè salts. Egosi na contraindications na ojiji nke ọgwụ ọjọọ, "dopamine", ntụziaka na iji ya eme ihe na-enịm ke akwụkwọ anyị.

Pụtara nyere dị ka infusion ngwọta uche.

pharmacological e ji mara

"Dopamine" - a umi, a ọgụgụ akwara mbufe ozi. Na metabolic Njirimara nke dopamine bụ a precursor nke adrenaline na noradrenaline. The ọgwụ na-emetụta ndị kwekọrọ ekwekọ anabata, na na elu kasịnụ enhances ọrụ α- na β-adrenoceptors. "Dopamine" ọrụ na-iji na:

• nkwalite nke elu vaskụla eguzogide;
• ntọt ke systolic ọbara mgbali;
• mmetuta nke obi ọnụego;
• ụba gbasara obi mmepụta;
• obere mgbanwe obi ọnụego;
• ịrịba oxygen ọkọnọ.

"Dopamine" na-enhances ọbara eruba na ihe nile nke ụbụrụ, obi, akụrụ na eriri afọ. Mụbara glomerular filtration ọnụego na sodium excretion site na akụrụ.

"Dopamine" - a ngwa-ngwa-eme ọgwụ. Mgbe 5-10 nkeji mgbe m / v infusion ọrụ na-agwụ. The ọkara ndụ - odika nkeji abụọ. Ọkara nke umi interacts na a protein na ọbara plasma. The ọgwụ na-aga ngwa ngwa metabolism usoro na akụrụ, imeju na-na ọbara plasma n'ihi na mmetụta nke Mao na catechol-O-methyltransferase ka a ala nke na-adịghị ejekwa metabolites na-arụsi ọrụ ike na-emepụta site na akụrụ. A nkeji iri na ise nke na ojiji nke dose na-ghọrọ ka nọrepinefrini na adrenergic akwara pulite. N'ihi na-arụsi ọrụ ike iwepụ bụghị ìgwè nke ọgwụ na ahụ mmadụ, ọbụna mgbe a ogologo oge nke n'ikuku.

"Dopamine": ngwa

Egosi maka ndibọbọ:

• Iche iche na ụdị nke ujo, dị ka a na-akpasasị uche, cardiogenic, postoperative, hypovolemic, endotoxin.
• Nnukwu vaskụla na obi ọdịda.
• Low gbasara obi mmepụta.

"Dopamine" na cardiogenic ujo mkpa pụrụ iche, ọ enwekwu myocardial contractile ọrụ.

The ọgwụ na-ndinọ intravenously. 125 ma ọ bụ 400 ml nke ise percent ngwọta nke sodium chloride ma ọ bụ glucose ngwọta dị mkpa na 25 ma ọ bụ 200 mg karị. N'ihi ya, 1 ml nke ngwọta nwetara 200 ma ọ bụ 500 .mu.g umi. Ọ bụrụ na onye ọrịa nwere ike ghara ndinọ nnukwu mpịakọta nke ọmụmụ nwere ike ihe ndọpụ ngwọta ka 1 ml nke 800 micrograms bụ "dopamine". Iji mee nke a, na-200 mg kwa 250 ml nke ngwọta. Ọnụego nke iwebata esịmde 1-4 ug / n'arọ kwa nkeji ná nkezi ahu arọ nke 70 n'arọ (2 to 11 tụlee nke 0,05% ngwọta ma ọ bụ site na 1.5 6 tụlee nke 0,08% ngwọta). The ọgwụgwọ onunu ogwu - si 5 9 mg / n'arọ na 1 min. Ọnụọgụ ọgwụ "dopamine" 10-15 .mu.g / n'arọ kwa nkeji bụ bara uru na vasodilation na hypotension. Ndị nlekọta na ọnụego nwere ike mụbara ruo 18 .mu.g / n'arọ kwa nkeji. The infusion na-ewe ebe na-enweghị nkwụsị na-ekpuchi oge site 2-3 awa na 1-4 ụbọchị ma ọ bụ ogologo. The dose kwa ụbọchị adịghị nnọọ 800 mg. Na iwebata "dopamine" ẹkenịmde ECG nlekota oru. Mkpebi siri ike nke dose na ọnụego nke ochichi na-dị ọbara mgbali, obi ọnụego, gbasara obi mmepụta, obi ọnụego na diuresis. Ọ bụrụ na hypotension anaghị ibili, ebelata mmamịrị mmepụta, ndị dose ga-belata.

contraindications

The ọgwụ na-contraindicated na ihe omume nke nsogbu ndị dị ka:

• arrhythmia;
• pheochromocytoma;
• prostatic hypertrophy;
• mmechi glaucoma.

mmetụta

Iwebata nke umi ke nnukwu doses, a elu larịị nke "dopamine" nwere ike ime ka mmetụta, gụnyere:

• tremor;
• tachycardia;
• vasospasm;
• arrhythmia;
• mebiri nke akụkụ okuku ume na n'afọ iri na ụma;
• anginal na isi ọwụwa;
• psychomotor n'ahụhụ ;
• ọzọ ngosipụta Adrenomimeticalkie edinam.

Ebe ọ bụ na mkpochapu "dopamine" na-arụ ọrụ, n'elu mgbaàmà akwụsị ma belata dose ma ọ bụ kwụsị ochichi nke ọgwụ. Ọ bụrụ na n'afọ iri na ụma na-agbajikwa, ọ dị mkpa iji antiarrhythmic ọgwụ ọjọọ, gụnyere "Verapamil", "lidocaine" na ndị ọzọ. Extravasation ngwọta "dopamine" nwere ike ime ka necrosis nke subcutaneous adipose anụ ahụ na nke anụ.

adọ aka ná ntị

"Dopamine" n'oge ime nwere ike a ga-amanye naanị mgbe ọ dị mkpa n'ezie ọgwụgwọ maka nne ya, na ọgwụgwọ mmetụta dị elu karịa ihe ize ndụ na nke nwa ebu n'afọ.

Fresh ngwọta kwesịrị inwe a uzo udidi na-akọ extraneous hue.

Imekotaotuugbo ọgwụgwọ na ọgwụ ọjọọ ndị ọzọ

The ọgwụ nwere ike iwere ke ukem na gbasara obi glycosides na diuretics (e.g., furosemide na ndị ọzọ). Hypovolemic ujo na-achọ iwebata "dopamine" tinyere ọbara n'ozuzu ya, plasma ma ọ bụ plasma nọ n'ọnọdụ.

Ejila "dopamine" n'otu oge na "cyclopropane", Mao inhibitors na mmadụ maka ná Nkụnwụ na okirikiri ọkụ n'isi ( "Halothane" na ndị ọzọ).

Ngwa agha mix Nwa adịghị anakwere na alkaline ngwọta nke ọgwụ ọjọọ ndị ọzọ.

"Dopamine" - a ọgwụ nke na-eji naanị na ndenye ọgwụ. Ya price na-adabere na onunu ogwu na ọnụ ọgụgụ nke ampoules na a ngwugwu, sitere na site na 80 ruo 300 rubles kwa mkpọ (5-10 ampoules).