"Nimesulide" mkpụrụ ọgwụ. Ntuziaka maka ojiji, n'ezie na ogbo

Pain - bụ ụdị iji nke ahụ iji na-adọta uche nke onye ahụ, na-akpọ maka enyemaka. Ya mere ihe ọjọọ na ihe "na Danish alaeze", na akụ nke ahụ bụ ezughị idozi nsogbu, anyị kwesịrị nkwado si n'èzí.

Consumer-emepụta ọgwụ ahịa nke Russian Federation ọkọnọ narị ọgwụ ọjọọ na-enyere ndị mmadụ aka ịnagide ihe mgbu. All ọgwụ dị iche iche mejupụtara, akporo na usoro nke mmetụta. Otu n'ime ihe ndị kasị dị irè bụ ọgwụ ọjọọ si na ìgwè nke ndị na-abụghị steroidal mgbochi mkpali ọgwụ ọjọọ. Otu n'ime ha bụ nkwusioru na mbadamba "Nimesulide".

Structure na mejupụtara

Now mbadamba nwere a lenticular udi. Na agba nwere ike acha odo ma ọ bụ nanị odo. Isi nọ n'ọrụ akụrụngwa - a umi Nimesulide ọ bụla mbadamba - 100 mg. Site a ọnụ ọgụgụ ike na-akpọ ndị ọzọ microcrystalline cellulose, starch (oka), sodium starch glycolate, colloidal sịlịkọn dioxide.

Ke adianade do, ọgwụ na-awa na-eji ọkụ na ụdị ntụ maka nkwusioru "Nimesulide." Mejupụtara bụ otu ihe ahụ dị ka nke mbadamba, ọ bụla 100 mg sachet Isi nọ n'ọrụ akụrụngwa.

pharmacodynamics

Nimesulide bibiri egbochi cyclooxygenase-2, cyclooxygenase-1, mmetụta ya nke ọma bụ na a ukwuu nta ruo n'ókè. Na nke a, na mgbochi nke prostaglandins njikọ hụrụ kpasue mkpali mmeghachi omume. Otú ọ dị, e guzobere prostaglandin-ụdị usoro iwu nimesulide akpa sonso nke nganu uche mmetụta, n'ihi na di ntakiri nnochianya ngosipụta nke digestive usoro.

Ke adianade do, irè ihe nke nimesulide gosi na mgbochi nke guzobere free radicals. Otú ọ dị, usoro nke hemostasis na phagocytosis anaghị ata ahụhụ mmetụta nke a umi. The usoro nke mgbochi mkpali mmetụta dọgburu agwọ ọrịa enyene ohere na ya ike na-ebelata ntọhapụ nke myeloperoxidase (na ọtụtụ mkpali oria nwere ike ime ka anụ ahụ mebiri, ọ bụ otu n'ime ihe ndị kasị ezi-achọpụta ọrịa e ji mara indicative nke nwere ihe ize ndụ nke nkụchi obi ma ọ bụ ọrịa strok).

Egosi maka ojiji

Wide ezu akporo nke ọgwụ "Nimesulide". On ihe na-eme ka a ọgwụ? N'ihi na ọgwụ nwere na mmadụ mgbagwoju mmetụta - antioxidant, analgesic, antipyretic na mgbochi - mgbe ọ na-kenyere na a ọnụ ọgụgụ nke mkpali oria. Irè ọgwụ ọjọọ na n'iru osteoarthritis (-adịghị ala ala na nkwonkwo na ọrịa na akpa ebe-ebibi articular cartilage), tendinitis (mbufụt nke akaị na anụ ahụ mbelata), bursitis (mbufụt nke mucous akpa, nkwenkwe nkwonkwo).

Arụpụta ezi na-egosi "nimesulide" na ọgwụgwọ nke ọrịa ogbu ogbu na nkwonkwo, mmezi-articular rheumatic ọrịa. Ọma-alụ ọgụ megide na-efe efe na-ebu mkpali Filiks. Ọtụtụ mgbe, "Nimesulide" mbadamba-eji na ọrịa ụmụ nwanyị, ọgwụgwọ nke unan nke dị iche iche si malite. Ọrịa na-ekwu na irè mkpochapu mgbu n'oge postoperative ghara ịgbanwe.

Contraindications "nimesulide"

Ebe ọ bụ na agwọ ọrịa na-ezo aka a ìgwè nke oge a National Nzute Square, o nwere nnọọ ọtụtụ ihe ndepụta nke contraindications. "Nimesulide" (site na ihe na-enyere ndị na nkà mmụta ọgwụ - e tụlere na mbụ) ikpenyeneke ndị mmadụ na hypersensitivity ọ bụla akụrụngwa ya mejupụtara. Ọ dịghị ọgwụ ndinọ ndị ọrịa na a akụkọ ihe mere eme na-egosi hepatotoxic Jeremaya mere na hypersensitivity Jeremaya mere ka rhinitis, bronchospasm, urticaria (na aspirin ma ọ bụ ndị ọzọ NSAIDs nnọchiteanya nke otu).

Contraindications na ojiji nke agwọ ọrịa bụ nwere bụla erosive-ulcerous ọnya nke digestive usoro, ọchịchọ ịzụlite ọbara ọgbụgba nke ọ bụla si (t. E. ọdịiche na ịrụ ọrụ nke ọbara clotting).

Medicine "Nimesulide" ntụziaka machibidoro ọrịa na gbasara akụrụ, hepatic, gbasara obi insufficiency. Ọrịa na "aspirin" ụkwara ume ọkụ, mmanya na ọgwụ ọjọọ na nduzi na-adịghị-ọgwụ.

Ekwela idepụta ọgwụ n'ebe ndị ahụ, ma ọ bụrụ na onye ọrịa na-ụba ahu okpomọkụ ma ọ bụ ndị ọzọ flu-dị ka ihe mgbaàmà na-hụrụ. Ke adianade do, ọ bụ adịghị anakwere na-"Nimesulide" ụmụ, ime, lactating inyom.

Ekwe Omume n'akụkụ Jeremaya mere "nimesulide"

Ngwa nke agwọ ọrịa nwere ike ime ka a ọnụ ọgụgụ nke mmetụta si dị iche iche na akụkụ na usoro nke ahụ mmadụ.

The kasị Jeremaya mere na-dere site digestive usoro, ma ha na-egosipụta site ọgbụgbọ, vomiting, afọ ọsịsa, flatulence, na mmepe nke mgbu. Obere mgbe ime eriri afọ agba ọbara, onya ruo mgbe perforation. Mgbe ụfọdụ, i nwere ike na-anụ banyere dyspepsia, stomatitis, abdominal mgbu.

Nwere ike ime ka "nimesulide" n'akụkụ ihe ahụ hepatobiliary usoro, ihe ka ọtụtụ gosi na ụba imeju enzyme etoju, ọ dịkarịa ala - na mmepe nke ịba ọcha n'anya (gụnyere fulminant ..), Cholestatic jaundice.

On mmeghachi omume nke obi usoro nwere ike ikwu, ma ọ bụrụ na e nwere otu ebe ọbara mgbali elu, ọrịa adịkarịghị nchegbu banyere obi palpitations, hemorrhage, flushing, ọbara mgbali jumps.

Urinary usoro nwere ike ikwu na onye ahụ nke edema (bụghị mgbe), adịkarịghị - urinary njigide, hematuria, dysuria. Nnọọ adịkarịghị ọ pụrụ ịzụlite gbasara akụrụ odida, interstitial nephritis, oliguria.

Ekwe Omume Jeremaya mere nke CNS esiwak gosipụtara dizziness, malaise, asthenia. Obere mgbe nwere ike nụrụ banyere isi ọwụwa, somnolence mmepe (myirịta hypnotic ụra), Reye si syndrome (encephalopathy), hypothermia (ahu okpomọkụ ọnụ n'okpuru larịị chọrọ ịnọgide na-enwe kwesịrị metabolism). Mgbe ụfọdụ, i nwere ike na-anụ banyere ndị dị otú ahụ Jeremaya mere "Nimesulide", dị ka ịma jijiji, nchekasị, na-arọ nrọ.

Banyere lymphatic usoro na hematopoietic usoro, "Nimesulide" (Ntụziaka, enyemaka n'ọrụ reviews gosi na nke a ọmụma) nwere ike adịkarịghị akpasu anaemia, eosinophilia, ma obere yiri ka ịzụlite thrombocytopenia purpura pantsitopenicheskaya.

Ufodu, ma i nwere ike ịnụ banyere metabolic disturbances (hyperkalemia), dịghịzi usoro (hypersensitivity, anaphylaxis), akụkụ nke ọhụụ (bịara ikiri ọhụụ, clouding nke ubi), akụkụ okuku ume na, mediastinum (dyspnea, bronchospasm, ụkwara ume ọkụ ọgụ). E nwere ndị Jeremaya mere, nke na akpụkpọ subcutaneous anụ ahụ (sweating, itching, dermatitis, urticaria, erythema, nnọọ adịkarịghị - egbu egbu epidermal necrolysis, Stevens-Johnson syndrome).

dosing na ngwa circuit mode

Okenye ọrịa mbadamba "nimesulide" dụrụ ọdụ na-otu otu (100 mg) ugboro abụọ kwa ụbọchị. Ọ ka mma ime otú ahụ mgbe a nri na-aṅụ ọtụtụ mmiri maka a na-agwọ ya. Ọ bụrụ na ọ bụ a powder maka nkwusioru, mgbe ọdịnaya nke otu sachet E jiriwo na 100 ml mmiri. -Eto eto afọ 12 nke afọ ọ dịghị mkpa ịgbanwe dose, na ụmụaka a ọgwụ na-enweta ihe amachibidoro. N'ihe banyere ọgwụgwọ nke agadi ọrịa a dose ukpụhọde na-adịghị rụrụ.

N'ihi na ndị mmadụ na-ata ahụhụ site na hepatic insufficiency, creatine nwechapụ na nso nke 30-80 ml / min., The onunu ogwu bụghị ziri ezi. Ọ bụrụ na ndị na-egosi na-lowered (30 ml / min ma ọ bụ obere.) - machibidoro iwu na-enweta agwọ ọrịa.

Ndị a bụ ndị isi na-atụ aro maka n'ikuku nke ọgwụ "Nimesulide". The onunu ogwu a họọrọ minimally irè, na n'ihi nke kasị nso-ekwe omume oge, nke ga-ebelata ihe ize ndụ nke oghom mmetụta. Oke N'ezie nke ọgwụ na iji "Nimesulide" ga gafere 15 ụbọchị.

Oké onunu ogwu: Mgbaàmà, Ọgwụgwọ

Na-ewere ọgwụ "Nimesulide", ọ dị mkpa iji rube isi na doses na-atụ aro na ntụziaka ma ọ bụ họrọ ịga dibịa. Self-ochichi nke agwọ ọrịa na (ma ọ bụ) ya na-achịkwaghị achịkwa ojiji nwere ike ịkpata ovadozu. The ọtụtụ ugboro ugboro hụrụ ndị na-esonụ mgbaàmà: ọgbụgbọ, vomiting, na-agba ọbara, eriri afọ tract, iro ụra, lethargy, ọbara mgbali (ọbara mgbali elu), mgbochi nke akụkụ okuku ume ọrụ, nnukwu gbasara akụrụ odida.

Ọgwụgwọ bụrụ na nke ovadozu symptomatic, na-na-akwado agwa. Ngwọta nimesulide a ugbu a na-efu. Ọ bụrụ na ebe ọ bụ na overdosing ma ọ bụ na-ewere a elu dose of agwọ ọrịa na-adịghị gafere karịa 4 awa ahụ, onye ọrịa bụ a ọgwụ gastric lavage atụ aro n'ikuku absorbent (e.g., rụọ ọrụ carbon na ego nke 60-100 mg maka na onye toro eto) na ụfọdụ ụdị nke osmotic laxative ọgwụ.

N'oge nile nke ọgwụgwọ a ga-ọma-ekwu site ọkachamara ahụ ike na-arụ ọrụ umeji akụrụ. Ozi banyere ekwe omume nke mwepụ nke nimesulide si ahụ site hemodialysis adịghị. N'ihi na elu ogo ọgwụ nkịtị ka ndi na-edozi na-amanye diuresis bụghị irè.

Special ntuziaka

"Nimesulide" iji nweta a ọgwụ si pharmacies nke na-achọrọ, Otú ọ dị, kwesịrị iwere na ịkpachara anya. Zere yiri ngwa nke agwọ ọrịa ma ọ bụla ọzọ na-abụghị steroidal mgbochi mkpali mmadụ, analgesics ozi. Na mmepe nke ihe mgbaàmà nke ọrịa, imeju mmebi e ji mara (ọgbụgbọ, vomiting, anorexia, ọchịchịrị mmamịrị) ma ọ bụ dịkwuo larịị nke hepatic transaminases ngwa "nimesulide" ga-hapụrụ. Ọ bụrụ na e a fever ma ọ bụ flu-dị ka ihe mgbaàmà, ọgwụ a ga-kwụsịrị ozugbo.

Echebara ya ọrịa kwesịrị na ihe yiri na "Nimesulide" na-ewere ọgwụ na-amụba ihe ize ndụ nke eriri afọ ọnyá na ọbara ọgbụgba. Anya kenyere ọgwụ maka ndị na-ata ahụhụ site na ọnyá afọ ma ọ bụ Crohn ọrịa, ọnyá na-enwe a akụkọ ihe mere eme nke ndị agadi ndị ọrịa.

Persons onye mkpa iji "Nimesulide" tinyere aspirin na gbasara obi doses ga-kenyere Nchikota ọgwụ na gastroprotectives.

The iji "Nimesulide" (ma ọ bụ ihe ọ bụla ọzọ NSAID) na nnukwu quantities na a ogologo oge nke oge na-eduga ná a obere na-abawanye na ihe ize ndụ nke thromboembolic mberede (ọrịa strok, myocardial infarction, na na. N.).

Ọrịa dị iche iche obi nsogbu "Nimesulide" usoro nwere ike họpụtara naanị ma ọ bụrụ na a tụrụ anya na uru karịa ihe ize ndụ nke mmetụta.

The agwọ ọrịa nwere mmetụta ogo platelet ọrụ. Nke a na ozi dị mkpa ka ndị ọrịa na-ata ahụhụ site na hemorrhagic diathesis. Siri ike ọnya nke anụ Ọtụtụ ịzụlite n'oge ogologo oge "nimesulide". Ozugbo akpụkpọ rashes apụta, na-aghọ appreciable mmebi mucous membranes ma ọ bụ ihe ọ bụla ọzọ ofu ngosipụta nke ekweghị ibe nọrọ, ọgwụ ọgwụ ga-kwụsịrị.

The iji "Nimesulide" ụmụ nwaanyị dị ime nwere ike ịkpalite emechi ọbara duct tupu ọ dị mkpa, na-ebelata ibu nke mmiri ọmụmụ. Ekwe Omume ibute intrauterine agba ọbara, anam idem emem nke oru, ọdịdị nke edema. N'ihi nke a, abụ nne n'oge mbụ na nke abụọ trimesters nke afọ ime n'ikuku "Nimesulide" adịghị atụ aro.

Ọ ga-abụ azịza nke ajụjụ bụ ma anyị nwere ike na-"Nimesulide" n'out oge na-aba n'anya, ọ bụ doro anya: ndị dị otú ahụ a Nchikota na ekwegh!

analogs

N'okpuru analogs "nimesulide" na-ezo aka ọgwụ ọjọọ si NSAID iche iche nwere dị ka a Isi nọ n'ọrụ mgwa nimesulide (price ha ga oscillate na ihe dị otu nso ma ubé n'okpuru ya). The kasị mara na ọtụtụ ndị na-kenyere ọgwụ mkpara analogs gụnyere ọgwụ ọjọọ "Naiz" (jel, mbadamba, nkwusioru), "Nimesil" (ntụ) "Niemiec" (mbadamba) 'nimulid "(jel, mbadamba, nkwusioru mbadamba maka aṅụ) .

All analogs nwere zuru ezu arụmọrụ na kenyere obibi dị iche iche nke ọrịa, mkpali yi agwa.

price nso

Ahịa maka onwe ya "Nimesulide" na ya analogs bụ mkpokọta otu, ọ bụ ezie na anyị na-atụle ọgwụ na-eri ihe inweta a dịgasị iche iche nke ndị na-azụ. Mbadamba "Nimesulide" (20 PC. Na a mkpọ) ga-eri 85-90 rubles kwa mkpọ. Otu nọmba nke mbadamba "Naiza" ga-eri 110-140 rubles, "Niemiec" (nwekwara 20 PC.) - na 115-134 rubles. Packaging "nimulid" nke 30 ọgwụ na-efu 180-220 rubles. The olu ọdịnaya nke Isi nọ n'ọrụ mgwa (Nimesulide) niile analogs otu - 100 mg.

Kama mbadamba "Nimesulide" (kasị ala na-eri) pụrụ inweta, n'ihi na ihe atụ, a slurry "Naiz" akwụ ụgwọ 200-300 rubles 60 ml ma ọ bụ "nimulid" - 75-105 rubles maka otu ego nke ọgwụ. Ọzọkwa dị ka a dịgasị iche iche nke na-eji ọkụ lozenges "nimulid": 20 mbak na a price 130-155 rubles kwa mkpọ.

Ikekwe, ihe kasị oké ọnụ ụdị ntọhapụ nke ọgwụ na nimesulide dị ka a isi akụrụngwa - a powder 'Nimesil ". 30 akpa (ngwugwu) ga-eri ihe ndị ahịa na ego nke si 560 na 645 rubles.

N'ihi Nde ngwa ndị dị irè gels na nimesulide. N'ihi ya, "Naiz" ga-eri 120-145 rubles maka a tube nke 20 g ma ọ bụ 215-275 rubles (50 g). Jel "nimulid" a obere bit dị ọnụ ala karịa: 115-150 rubles kwa tube olu nke '30

Ná mmechi ga-amasị m na-ekwu na-esonụ. The mkpebi na-eji "nimesulide", ọ bụla analogue ma ọ bụ ihe ọ bụla ọzọ NSAIDs kwesịrị iwere site ịga dibịa. Naanị ike ọkachamara nwere ike n'ụzọ kwesịrị ekwesị na-amata ịdị njọ nke ike nke ndị ha na-agwọ, na-atụle ihe niile yiri ọrịa, họrọ ọgwụ onunu ogwu họrọ na ịzụlite a ọgwụgwọ plan iji iwelata likelihood nke mmetụta na-enweta ndị kasị mma na-arụpụta.