Ọgwụ "Letrozole": ntụziaka ntuziaka, reviews na analogues

N'ihi nzube dị aṅaa onye ọrịa ọgwụ 'Letrozole' nwere ike họpụtara? Ntuziaka maka ojiji nke ọgwụ na-kọwara n'ụzọ zuru ezu nke isiokwu a. Ọzọkwa, o nwere ihe ọmụma banyere otú ọ bụ uru banyere ọgwụ, ma ọ bụrụ na o nwere ọ bụla analogues, oghom Jeremaya mere na contraindications na-ekwu banyere ya, ndị ọrịa na na na. D.

The udi, nkọwa, mejupụtara, nkwakọ

Ihe e lere 'Letrozole' nkwadebe? Medicine, atụle site anyị, e dere ihe n'ọrụ mgwa nke otu aha. Ọ na-agụnye inyeaka mmiri ka cellulose, lactose monohydrate, starch, sodium carboxymethyl starch, colloidal anhydrous silica na magnesium stearate.

A ọgwụ na-ahịa dị ka a gbara ọchịchịrị na-acha odo odo film-ntekwasa mbadamba. Ha na-okirikiri na lenticular ụdị.

Drug "Letrozole ', ego nke nke na-egosi n'okpuru, na-ere na nchịkọta nke ngwe, na-enịm ke a ikpo nke kaadiboodu.

Ọ kwesịkwara kwuru na dabere na emeputa na-ewere ọgwụ nwere ike a dị iche iche udi, nkwakọ ngwaahịa na mbukota.

pharmacodynamics nke ọgwụ

Olee ihe nwere ọgwụ 'Letrozole'? Ntuziaka maka ojiji na-ekwu na ọ bụ ihe antineoplastic gị n'ụlọnga na-egbochi njikọ nke estrogen.

A ọgwụ bibiri egbochi aromatase, nke na-anọchi anya a dị nnọọ mkpa ndu enzyme estrogen njikọ. Na nke a emee ruru ka a ukwuu kpọmkwem nkịtị ka ihe nke si enzyme.

Dị ka ọmụmụ, "Letrozole" ike nke na inhibiting na biosynthesis nke oestrogens na etuto ahụ na ahụ ike elu arọ.

Mgbe fairer mmekọahụ postmenopausal estrogens na-emepụta na kpọmkwem òkè nke aromatase. Ọ agbanwe androgens ka estrone na estradiol, na-ebilite na adrenal glands.

Proper n'ikuku nke a agwọ ọrịa (0.1-5 mg a ụbọchị) na-eduga ná a ọnụ ke ọbara ịta nke estrone sulfate, estradiol na estrone na 95% nke mbụ ọdịnaya. Na nke a, njikọ nke estrogen a ga-ewute ya nile ọgwụ.

Mgbochi nke njikọ nke estrogen enwekwu ịta nke androgens, nke bụ, n'eziokwu, na-anọchi anya ndị chemical precursors nke estrogens.

Olee ihe ndị ọzọ atụmatụ nwere ọgwụ "Letrozole?" The emeputa na-ekwu na n'oge ọgwụgwọ na a gị n'ụlọnga ke a obere ogo ụba ugboro ole nke osteoporosis.

Adjuvant ọgwụgwọ n'oge ara ọrịa cancer budata ebelata ihe ize ndụ nke nlọghachite na-amụba lanarị 5 afọ enweghị ihe ọ bụla anya ihe ịrịba ama nke na-enwe ọganihu. Ọzọkwa, a ọgwụ na-ebelata ohere nke metastasis na nke sekọndrị, etuto ahụ.

Na-aga n'ihu adjuvant ọgwụ na nke a pụtara na-ebelata ihe ize ndụ nke nlọghachite site banyere 42%.

Pharmacokinetics

Ebe absorption ewe ebe "Letrozole 'nkwadebe? Ntuziaka maka ojiji na-agwa anyị na mgbe onu ochichi nke ọgwụ kama ngwa ngwa etinye obi gị dum na gootu. Ya nkezi bioavailability nke 99.9%. Na nke a na-eri ihe nke ukwu-ebelata absorption ọnụego.

Time of omume nke kasị elu ịta na ọbara bụ 60 nkeji mgbe na-ewere ọgwụ na ihe efu afo 120 nkeji na n'ikuku ọnụ na nri.

Communication na plasma protein esịmde banyere 60%. The ìgwè nke nọ n'ọrụ umi na ruo ogologo oge iji ọgwụ na-adịghị akara.

Drug metabolism emee na guzobere na-adịghị ejekwa metabolite. Ya mkpochapu a rụrụ na mmamịrị, nakwa dị ka site na eriri afọ. The ọkara ndụ nke ọgwụ bụ ụbọchị 2.

egosi

Maka ọgwụgwọ nke ọ bụla ọrịa eji a ọgwụ dị ka "Letrozole?" Ọbịa ọkachamara na-ekwu na-egosi maka ojiji nke ngwá ọrụ a na-na-esonụ ọrịa:

• Ịza aza neoplasms nke ara ná mmalite nkebi nke postmenopausal ọgwụ mgbe ẹkụre ọkọlọtọ "tamoxifen" (mee ka ihe ndị ọzọ ruo ogologo oge ọgwụgwọ).
• Ịza aza neoplasms nke ara na n'oge ogbo (akpụ uto a kpaliri site estrogens) na fairer mmekọahụ postmenopausal (eji dị ka onye ọzọ ọgwụgwọ).
• Common malignancy ara cancer na postmenopausal si ndị mmadụ ndị ugbua natara ọgwụgwọ na antiestrogens.
• Common iche nke hormone-ndabere ara malignancies na postmenopausal (mbụ akara ọgwụ).

contraindications

N'okpuru ihe ọnọdụ ike iwere "Letrozole?" Analogs nke a ọgwụ na ọgwụ onwe ya na-adịghị akwadoro maka ọrịa na:

• mmiri ọgwụ ọnọdụ, e ji mara ndị na-eme nri oge ;
• ara;
• uche na isi na ndị ọzọ ọgwụ bekee;
• ime;
• na nwata.

Ọ kwesịkwara kwuru na ihe ókè ịkpachara anya nyere ọgwụ na-eji maka lactase erughi, lactose ekweghị ibe nọrọ, nakwa dị ka glucose-galactose malabsorption.

The ọgwụ 'Letrozole': ntuziaka maka ojiji

Na ihe onunu ogwu ọgwụ ọgwụ na ajụjụ? Ịnọgide na-enwe n'ikuku nke ndị dị otú ahụ a ọgwụ kwesịrị na kenyere onye dọkịta. Na dọkịta, dabeere na data analysis na ọgwụ na nnyocha dị ka a dum, ga-ekpebi na onunu ogwu nke ọgwụ na ugboro ole nke ha were.

"Letrozole" ọgwụgwọ gbatịrị ruo ogologo oge. Ọgwụ e ji ọnụ na, n'agbanyeghị nri oriri. Dị ka ntụziaka, na-atụ aro usoro onunu ogwu nke ọgwụ bụ 2,5 mg otu ugboro n'ụbọchị.

Ọgwụ ga-a kwa ụbọchị n'ihi na 5 afọ ma ọ bụ ruo mgbe ọzọ.

Ọ bụrụ na ọgwụ na-eji na adjuvant ọnọdụ, mbadamba oriri ga-ruo 4 afọ. Na progression nke cancer agwọ ọrịa na-agbanwe.

Na mmadụ nke na-adịghị ike na mmekọahụ na cancer ke akpatre ogbo, ma ọ bụ na-egosi na metastatic ọgwụ a chọrọ ka ọ dịgide ruo akpụ progression akpọ.

ikpe nke ovadozu

Ugbu a na ị maara otú ime ka 'Letrozole'. Otú ọ dị, nke a ga-eme nanị mgbe oge na dọkịta gị. Na elu doses nke ọgwụ a ndidi nwere ike ịzụlite ekwesighi mmetụta. Ugbu a, e nwere ndị a ọnụ ọgụgụ nke kọrọ ikpe nke na-ewere ọgwụ ovadozu.

Dị ka ọgwụgwọ nke ọnọdụ ndị dị otú na-eji na-akwado na symptomatic ọgwụ. Specific ụzọ iji kpochapụ ihe ịrịba ama nke ovadozu na e mepụtara. Ndọrọ ego nke ọgwụ n'ebe ọbara site hemodialysis.

The agwọ ọrịa "Letrozole": oghom Jeremaya mere

Ọ bụla oghom Jeremaya mere ime mgbe ochichi nke ọgwụ 'Letrozole'? Anticancer ọgwụ mgbe mgbe ka achọghị mmetụta. Tụlee a ndepụta ha ugbu a:

• Digestive usoro: abdominal mgbu, stomatitis, afọ ọsịsa, dyspepsia, ebighị nke hepatic enzymes, ọgbụgbọ, akọrọ ọnụ, afọ ntachi, vomiting.
• Ụjọ usoro: somnolence, dizziness, paresthesia, ịda mbà n'obi, ebe nchekwa na ọnwụ, nchegbu, ehighị ụra nke ọma, ahụ mgbakasị, hypoesthesia, nervousness agafe na-enwe nsogbu ọrịa ụbụrụ mgbasa, dysesthesia.
• Akụkụ okuku ume na usoro: ụkwara, mkpụmkpụ nke ume.
• hemopoietic usoro: leukopenia.
• Skin Jeremaya mere: alopecia, sweating, urticaria, anaphylactic Jeremaya mere, ihe ọkụ ọkụ, angioedema, akọrọ anụ ahụ, itching.
• ọbara usoro (obi) ịrịa ọrịa obi, tachycardia, thrombosis, palpitations, ọbara thrombosis, akpa ume embolism, thrombophlebitis, elu elu na nke miri emi akwara thrombosis, ọrịa strok, na-amụba nsogbu.
• Nweekwa usoro: osteoporosis, arthralgia, ogbu na nkwonkwo, myalgia, fractures, ọkpụkpụ mgbu.
• Urogenital: iche iche na-efe efe, Ugboro urination, mmamiri ihapu, ọbara ọgbụgba, ihe mgbu na obi.
• Uche ziri ezi: a rụrụ arụ na-uto, cataracts, bịara ikiri ọhụụ.
• Mmeghachi omume ndị ọzọ: akọrọ mucous membranes, generalized edema, na-ekpo ọkụ mgbukepụ paroxysmal, malaise, ike ọgwụgwụ, pyrexia, asthenia, ihe mgbu na akpụ ọnya na elu edema.
• Metabolism: ibu ibu, na arọ ọnwụ, hypercholesterolaemia, anorexia, mụbara agụụ, mgbe nile akpịrị ịkpọ nkụ.

Drug interactions na kpọmkwem na-atụ aro

Clinical ọnwụnwa maka inweta akuko nke ọgwụ na Nchikota na ndị ọzọ anticancer ọgwụ ọjọọ na e duziri.

Iji 'Letrozole', nke reviews na-agwakọta, o nwere ike imetụta mmadụ ike ụgbọala, nakwa dị ka ọrụ na mgbagwoju usoro.

Ikweta na ọgwụ na egwuregwu

Agwọ ọrịa 'Letrozole' bodybuilding na-eji ezi mgbe. Ọtụtụ na-eme egwuregwu na-ekwu na-ewere ndị dị otú ahụ ọgwụ ọjọọ eme ihe na-eduga ná igbochi njikọ nke estrogen, na-enwekwu ndị na mmepụta nke androgens. Otú ọ dị, ahụmahụ ndị ọkachamara na-ekwu na nke ikpeazụ bụ ezi mmetụta na a pụtara ndị ọkà mmụta sayensị. Banyere nke a, ndị dọkịta na-ọ na-adịghị atụ aro iji na 'Letrozole' na bodybuilding. Firstly, ọ nwere ọtụtụ kpọmkwem contraindications, na abuo, na-arụsi ọrụ ike agwọ ọrịa nwere ọnụ ọgụgụ dị ukwuu nke mmetụta.

N'ihi ya, mgbe ochichi nke a isiokwu maka ọgwụ ọgwụ na-adịghị na-eme egwuregwu na-egosi ike budata njọ.

nchekwa na ire ọnọdụ, adị ndụ

Ebe m nwere ike ịzụta ọgwụ 'Letrozole'? Analogues nke ngwá ọrụ a na nkwadebe onwe ya a na-eresị na fọrọ nke nta niile drugstores. Otú ọ dị, ọ hapụrụ nditịm na ndenye ọgwụ.

Buru a na-achọsi ike agwọ ọrịa na a akọrọ, ebe gbara ọchịchịrị na okpomọkụ ruo 25 degrees, ebe e nweghị ohere obere ụmụaka. Adị ndụ nke ọgwụ bụ 24 ọnwa. Mgbe oge a na ọgwụ ọjọọ nwere ike iji.

Akwụ ụgwọ na ụtụ isi nke ọgwụ

Ị maara otú ọ na-efu ọgwụ 'Letrozole'? The price nke a ọgwụ nwere ike ịdị iche ubé dabere na mpaghara, na-emeputa n'akụkụ peeji na ahịa ọgwụ na netwọk. The nkezi na-eri nke ndị dị otú anticancer ọgwụ ọjọọ bụ 1500 rubles (30 mbadamba). Otú ọ dị, nke a price na-emetụta nanị nkwadebe nke ụlọ mmepụta. The agwọ ọrịa nke Spanish ụlọ ọrụ "Kent Pharma" bụ ihe dị oké ọnụ (banyere 2600 rubles).

Nyere na mkpụrụ ọgwụ "Letrozole" (mmetụta e kwuru banyere ha n'elu) na-adia a ọtụtụ afọ, ọgwụgwọ nke malignancies ndidi na-akwụ ụgwọ ndị dị oke ọnụ.

Ụfọdụ ndị ọrịa bụ ndị na-enweghị ike ịzụta ọgwụ atụle, dochie ya site n'ụzọ ndị ọzọ (naanị mgbe oge na dọkịta gị). Site analogues nke ndị dị otú ahụ ọgwụ ọjọọ eme ihe na-agụnye ndị na-esonụ ọgwụ: "Aralet", "Etruzil", "Lerzy", "Femara," "Letrozole Teva", "Letrotera", "Letromara".

Ọ ga-kwuru na ndị na-eri ndị a ọgwụ ọjọọ nwere ike ịbụ elu mbụ na n'okpuru. Ka ihe atụ, 30 mbadamba nkume nke ọgwụ ọjọọ, "Femara" na-eri ihe 7700 rubles. Otú ọ dị, ha arụmọrụ bụ bụghị ọtụtụ elu karịa nke "letrozole".

Ọrịa 'Ọgwụ

Chọta reviews nke ọrịa na-ewere nkwadebe bụ siri ike. Ndị na-cancer na-ala azụ na-ekerịta ihe ọgwụ. Ọtụtụ n'ime ha na-jikwaa iji nweta mgbaghara. Ọ bụ ezie na ụfọdụ ndị ọrịa na-ekwu na ọgwụ 'Letrozole' ka nyere ha olileanya maka a ogologo ndụ.

Dị ka ndị ọkachamara, ha reviews bụ naanị mma. Dabere na ala nabatara ma pụtara ọkà mmụta sayensị nti data, ha na-ekwu na n'etiti ndi nile antineoplastic ọgwụ ọjọọ "Letrozole" agwọ ọrịa bụ ihe kasị irè n'aka maka ọgwụgwọ nke ịza ara etuto ahụ.

Ọ kwesịkwara kwuru na ọtụtụ ndị ọrịa iwe iwe price nke a ọgwụ. Ọtụtụ n'ime ha nwere ike imeli ịzụta a na nkà mmụta ọgwụ na njọ ha na otú ejighị n'aka obi ala. Otú ọ dị, pharmacists-arụ ụka na ihe pụrụ iche technology maka mmepụta nke dị mbadamba anaghị ekwe ka ha mee a ala price.

Ma mmetụta, dị ka uche nke ndị ọrịa, ha adịghị egosi otú akpọ, dị ka e gosiri ntuziaka (karịsịa megide ndabere nke ẹdude mgbu). Ọtụtụ mgbe, a ọgwụ nwere ike ime ka ọgbụgbọ, tachycardia, urticaria, ogwe na afọ ọsịsa. Ma, ọtụtụ ndị na-ewere ndị a mbadamba, dị njikere idi niile mmetụta, ma ọ bụrụ na naanị ogologo okwu ọgwụgwọ so mee ka mmepe nke ngbaghara.