Ọgwụ "Leykostim": ntuziaka maka ojiji, n'ezie na ogbo

Gịnị bụ ọgwụ "Leykostim"? Ntuziaka, ntọhapụ ụdị, na-egosi na contraindications ka a ọgwụ ga-kọwara n'okpuru ebe a. Anyị na-agwa gị banyere ihe analogs dị maka na ngwá ọrụ a gụnyere ya mejupụtara, na na.

The udi, nkwakọ, akụkụ nke ọgwụ

Olee ụdị ka ọgwụ "Leykostim"? Ntuziaka maka ojiji na-akọ na-arụsi ọrụ ike agwọ ọrịa na-arụpụtara dị ka ihe ngwọta maka subcutaneous ma ọ bụ igba ogwu n'akwara ochichi.

N'ọrụ akụrụngwa nke gị n'ụlọnga bụ filgrastim. Ọ bụ a recombinant granulocyte ógbè-akpali akpali na-akpata. 1 ml nke ọgwụ ngwọta nwere ike ịnwe 300 mg (30 nde. IU), 600 mg (60 nde. IU) ma ọ bụ 150 micrograms (15 nde. I.U.) filgrastim.

Ma ihe ndị excipients, mgbe ahụ, ha na-eme dị ka mannitol, sodium acetate trihydrate, dextran, acetic acid, polysorbate, na mmiri ogwu ogbugba.

Na a nkwakọ ngwọta na-ere "Leykostim"? Ntuziaka maka ojiji agbakwunyere na a kaadiboodu igbe na otu ma ọ bụ ise vials nke ọgwụ.

Njirimara nke ọgwụ

Gịnị bụ usoro nke edinam nke ọgwụ na "Leykostim"? Ntuziaka maka ojiji, dọkịta reviews ekwu na ọ bụ a ọgwụ ọjọọ na-immunomodulator. Ọ bụ a ukwuu ọcha na-abụghị glycosylated protein nwere a usoro iwu mmetụta na mmepe na ije (site na ụmị ọkpụkpụ n'ime ọbara) ọtọ neutrophils.

Mgbe iwebata ọgwụ budata enwekwu ọnụ ọgụgụ nke neutrophils n'ime ọbara na ubé - monocytes. Na nke a emee n'ime 24 awa.

The abawanye na ọbara neutrophils bụ dose-ndabere. Ọgbọ nke biologically ifịk protein, i.e. filgrastim, nke apụta ihe ndị proliferation na iche nke mkpụrụ ndụ na-ebu site na-akpata nsogbu nke bacteria Escherichia coli. Na mberede, nke ikpeazụ, n'ihi na ike nke oge a na nkà mgbanwe mkpụrụ ndụ, complemented site n'usoro granulocyte ógbè na-akpali akpali mmadụ na-akpata.

Dị ka ya ụkpụrụ nke mmetụta na-ahụ ọgwụ ọjọọ yiri granulocyte ógbè-akpali akpali ihe na-akpata, nke bụ nke eke si malite. The naanị iche nke bụ eziokwu na "Leykostim" (ngwọta) na-adịghị glycosylated, na nwere N-ọnụ amino acid fọduru nke methionine.

Atụmatụ nke ọgwụ

Olee ihe nwere na nkà mmụta ọgwụ "Leykostim"? Ntuziaka maka Iji na-ekwu na ọ ga-eji na nchoputa nke neutropenia na ndị na-ata na-anara ọgwụ. Ọzọkwa, a ọgwụ dị irè maka ala ala neutropenia. Nke a bụ n'ihi na eziokwu na ọ bụ ike iji weghachi ezigbo ọnụ ọgụgụ nke neutrophils na ahụ mmadụ.

Iji Nwa maka mgbochi ahụ, onye ọrịa nwere ike budata belata omume nke neutropenia, nakwa dị ka belata mgbagwoju nke eruba na oge oge nke ọrịa. Ndị dị otú ahụ n'ebe na-egbochi na-efe efe nsogbu, belata ọrịa ogologo nke ụlọ ọgwụ na ọnụnọ, na-enye ohere na-anara ọgwụ enweghị si n'ebe bụ okwu ndị na-e guzobere general atụmatụ nke ọgwụgwọ.

Dị ka ahụ mmadụ na-eme "Leykostim"? Ntuziaka maka ojiji na-egosi na ojiji nke ọgwụ na-eme ka direction na elu mkpụrụ ndụ ọbara tupu hematopoiesis, nke e anakọtara site cytapheresis (i.e., nke kewara ọbara n'ime cellular akụrụngwa na nhọrọ mwepụ) na ndinọ onye ọrịa mgbe a N'ezie nke elu-dose ọgwụ.

N'aka nke ya, na-agbara sel (azuokokoosisi) inwe hematopoietic ọrụ, belata dịghịzi na hematopoietic usoro, nakwa dị ka belata ihe ize ndụ na ogo nke na-efe efe na hemorrhagic nsogbu.

ọgwụ nchekwa

Ọ bụ nchebe nke ụmụ mmadụ na ọgwụ ọjọọ, "Leykostim"? Manual na-ekwu na a ọgwụ ike ga-eji n'ihi na ma ụmụaka na ndị okenye. Ọ bụkwa mma maka mmadụ nile na-anata cytotoxic ọgwụ.

Ọrịa na immunodeficiency virus ngwa ngwọta na-enye kacha larịị nke neutrophils na-enye ohere na-eso niile na-atụ aro Dosages alụso nje virus ọgụ ma ọ bụ myelosuppressive ọgwụ.

Mgbe na-eji ngwaahịa a nke nje HIV nọ na-hụrụ.

Pharmacokinetics

Gịnị pharmacokinetic ọgwụ nwere "Leykostim"? Ntụziaka na-egosi na ịta nke nọ n'ọrụ mgwa nke a gị n'ụlọnga bụ kpọmkwem dabere na ndinọ dose.

Mgbe subcutaneous ochichi, onye kasị ukwuu ego nke ọgwụ na ọbara hụrụ mgbe ihe dị ka 8-15 awa.

The ọkara ndụ "Leykostima" ifịk ifịk ihe onwunwe bụ atọ ka awa anọ. Filgrastim metabolized ka peptides. About 1% nke nọ n'ọrụ akụrụngwa na-egosi na-agbanweghi agbanwe na mmamịrị.

Filgrastim ìgwè ke ahụ mmadụ adịghị ime ọbụna mgbe ogologo oge eji ọgwụ ọjọọ (mgbe ọgwụ karịa ọnwa). Na oge a nke ya ọkara ndụ bụ otu ihe.

egosi

"Leykostim" ọgwụ nke na-kenyere ndị na-esonụ na nzube:

• maka mbenata oge nke neutropenia eruba emee 2-4, na-iji belata omume nke febrile neutropenia na ụmụ mmadụ na etuto ahụ nemieloproliferativnymi mgbe ọgwụ na cytostatic mmadụ;
• iji belata ngosipụta nke nsogbu na-ebilite mgbe neutropenia, nakwa dị ka mbenata oge N'ezie nke ọrịa na ụmụ mmadụ n'ịnwụ myeloablative ọgwụ na ụmị ọkpụkpụ transplantation mkpa;
• cell ebe bu ụzọ hematopoiesis na elu ọbara n'ihi nzube nke kewara na transplanting ha mgbe myelosuppressive ọgwụ;
• maka ọgwụgwọ nke neutropenia na ndị mmadụ na HIV ọrịa (gụnyere ndị na elu ogbo) iji belata ihe ize ndụ nke na-efe efe nke nje si;
• maka ọgwụgwọ nke ala ala neutropenia;
• cell ebe tupu hematopoiesis, na elu ọbara ike donors ka dọgharịala kewapụkwanụ ha na-arịa ọrịa.

contraindications

Gịnị bụ contraindications ọgwụ nwere "Leykostim"? Nyocha ọkachamara kọrọ ndị na-esonụ ukpan:

• ụba onye uche nke onye ọrịa na-arụsi ọrụ ike na ndị ọzọ na Efrata ke mejupụtara nke ọgwụ;
• congenital neutropenia, oké mmiri na-asọ na ya na cytogenetic ọrịa (Kostmann syndrome);
• neonatal oge (karịsịa ọnwa mbụ nke ndụ).

Drug "Leykostim": ntụziaka na ngwa

E lee ya anya ọgwụ ike ga-ndinọ na ụzọ abụọ:

• intravenously;
• subcutaneously.

Ọnụọgụ ọgwụ na usoro nke ochichi "Leykostima" kwesịrị ikpebisi ike site ọkachamara, dabere na-adakarị ọnọdụ ahụ, onye e ji mara onye ọrịa ahụ na ọrịa. Otú ọ dị, ọ ga-ahụ kwuru na ọgwụ na ahụ ike na-eme ya na-họọrọ subcutaneous ochichi nke ọgwụ.

Maka igba ogwu n'akwara ifịk agwọ ọrịa na-napụrụ vial site ntụtụ, na mgbe ahụ, ọ e kwukwara ka a mkpọ 5% dextrose. Ihe ngwọta na-ndinọ ka a ndidi maka ọkara otu awa.

Esi etinye "Leykostim"? Ntuziaka (analogues nke a na nkà mmụta ọgwụ a ga-atụle n'okpuru) kwuru na ọgwụ ga-eji mba mbụ karịa ụbọchị mgbe ọgwụgwụ nke na-anara ọgwụ.

The ọgwụ ngwọta e ndinọ dabere na ọrịa arọ. The dose àmà nke 5-12 mg kwa 1 n'arọ arọ. Ọgwụ na-rụrụ ụbọchị ọ bụla na a ugboro ole nke otu ugboro n'ụbọchị.

Agwọ a na-ewere ọgwụ ga-rụrụ dị ka ogologo dị ka ọnụ ọgụgụ nke neutrophils n'ime ọbara adịghị eru nkịtị etoju. A, na ọgwụgwọ oge bụ izu abụọ.

N'oge ochichi ọkachamara na-chọrọ mgbe nile chọpụta na ọnụ ọgụgụ nke leukocytes ke iyịp. Ọ bụrụ na ọnụ ọgụgụ dị ukwuu karịa 50,000 / microliter, ọgwụ agbanwe.

N'oge ọrịa, ọrịa nwere ike ịzụlite thrombocytopenia. N'ihe na ugboro ugboro assays na platelet ọnụ uru na-nọ n'okpuru 100,000 / microliter, mgbe ahụ, na-enyocha ruo nwa oge kagbuo nke ọgwụ ma ọ bụ na-ebelata ya onunu ogwu.

mmetụta

Dị ka ọnụ ọgụgụ, ọgwụ "Leykostim" adịkarịghị akpata oghom Jeremaya mere. Otú ọ dị, ọ ka nwere ike na-eme ka ntoputa nke ndị dị otú ahụ na mmetụta ndị dị ka:

• dysuria;
• mgbu na ọkpụkpụ ma ọ bụ uru;
• alopecia;
• hepatomegaly, splenomegaly;
• hypotension (-akwụsị akwụsị);
• ụba etoju nke uric acid na alkaline phosphatase;
• adịghị ike, isi ọwụwa na ike ọgwụgwụ;
• nfụkasị Jeremaya na mmalite nke ọgwụgwọ, nke na-erukwa mgbe igba ogwu n'akwara ochichi nke ọgwụ.

Ọ kwesịkwara kwuru na mgbe na-ekwesịghị ịdị injection nwere ike ịkpaghasị ndidi erughị ala na-agbanye na saịtị.

ọgwụ interactions

Tupu iji a ọgwụ, ị ga-chepụta otú na-emekọ ihe ndị ọzọ ọgwụ "Leykostim". Ntuziaka (njem nke ọgwụ na-ada ka "filgrastim") nwere zuru ezu ozi site na:

• Agwọ ọrịa "5-Fu" ewusi neutropenia.
• N'ihi na-eto eto myeloid mkpụrụ ndụ bụ oké mwute ka cytotoxic mmadụ, họpụta "Leykostim" kwesịrị a ụbọchị tupu ma ọ bụ mgbe ihe ndị a ọgwụ ọjọọ.
• E lee ya anya agwọ ọrịa ọ na-emegide sodium chloride.
• Mgbe na-eji ihe ngwọta na ntụziaka nke progenitor mkpụrụ ndụ na-esonụ na-anara ọgwụ a ga-atụle na arụmọrụ mbelata mgbe oru nchikota ndi mmadu di ngwa "carmustine" "Melphalan" na "carboplatin".

kpọmkwem na-atụ aro

Ọ na-adịghị atụ aro na-ekenye "Leykostim" ndị mmadụ na isi imeju ọrụ na akụrụ, dị ka filgrastim nchekwa na nrụpụta na ndị ọrịa a na a na-amụ.

Ọrịa na osteoporosis na ndị ọzọ na ọkpụkpụ ọrịa, onye na-eji ọgwụ ọjọọ nọgidere n'ihi na ọnwa isii, ị ga na-eduzi ndị na-achịkwa nke ọkpụkpụ njupụta.

Irè nke ọgwụ na ndị mmadụ na a obere ego nke myeloid progenitor mkpụrụ ndụ na a na-amụ. Otú ọ dị, ndị ọkachamara na-arụ ụka na ndị dị otú ahụ ọrịa ogo mmụba nke ọnụ ọgụgụ nke neutrophils nwere ike budata ala.

Nrụpụta na nchekwa nke "Leykostima" na ndị mmadụ na -adịghị ala ala myeloid leukemia na myelodysplastic syndrome adịghị ike. Banyere nke a, ndị dị otú ahụ ọrịa na-adịghị gosiri.

Monotherapy atụle bụghị ọgwụ na-egbochi anaemia na thrombocytopenia, nke na-kpatara myelosuppressive ọgwụ. Ọ na-achọrọ iji chọpụta na ọnụ ọgụgụ nke platelet na hematocrit. Akpan akpan ịkpachara anya ga-gosipụtara mgbe eji a otu-mpaghara ma ọ bụ Nchikota chemotherapeutic regimens, mara na ha nwere ikike na-eme ka oké thrombocytopenia.

Tupu ịmalite ọgwụgwọ, "Leykostimom" mkpa iji mee a zuru ezu analysis nke ọbara na a ụfọdụ ego nke platelet na leukocyte adabere, na ịchọpụta karyotype na ụmị ọkpụkpụ picture.

Mgbe oge nke ọgwụgwọ a chọrọ mgbe nile nyochaa mmamịrị na size nke splin.

Drug "Leykostim": analogs na price

Analogues ọgwụ ọjọọ na-atụle ndị na-esonụ ọgwụ ọjọọ: "Filergim", "Grasalva", "Granogen", "Neupogen," "leucite", "Neypomaks", "Mielastra", "Neyrostim".

Ma ihe ndị price, mgbe ahụ, "Leykostima" dị nnọọ elu. Zụrụ a ọgwụ na pharmacies na Moscow na ndị ọzọ na Russian obodo nwere ike ịbụ nke 2500-4500 rubles. The price nke a ọgwụ na-adabere na size na ọnụ ọgụgụ nke ampoules kwa mkpọ.

ọgwụ Nyocha

N'ụzọ dị mwute, reviews nke ọrịa ndị na-ewe nke a ọgwụ, dị nnọọ nta. Dị ka eziokwu na e nwere, ọgwụ Ọtụtụ kenyere dịghịzi usoro, nakwa dị ka cyclic neutropenia na ụmụ. Mmetụta nke ọgwụ ndị dị otú ahụ oké njọ nke ọrịa dị mkpụmkpụ.

Ọ kwesịkwara kwuru na e nwere ndidi testimonials na-adakarị iji "Leykostima" na ụmụaka na ndị okenye na neutropenia jikọtara cancer na-anara ọgwụ. Nkwadebe kenyere ụmụ ọhụrụ a onunu ogwu nke 5 mg / n'arọ kwa ụbọchị, kama ọma anabata.

Ụfọdụ ọrịa nwere mmasị na ajụjụ banyere ụdị ihe ngwọta dị mma: "Leykostim" ma ọ bụ "Neupogen". Dị ka a N'ihi nke na-adakarị ọnwụnwa ndị na e rụrụ ịmata tolerability na nrụpụta ọrụ nke ndị a elekọta mmadụ, ndị na-esonụ Nkwubi okwu ruru: deadlines maka mgbazi nke neutropenia mgbe iji ọgwụ kwuru na-adịghị akwanyere ùgwù. Ọzọkwa, ha nwere kpọmkwem otu egosi nke nrụpụta na tolerability.