Phospholipid syndrome: akpatara na Diagnosis

Phospholipid syndrome - a dịtụ nkịtị daa ọrịa nke autoimmune malite. Against ndabere nke ọrịa na-emekarị hụrụ vaskụla, akụrụ, ọkpụkpụ na ndị ọzọ na akụkụ. Na enweghị ọgwụ ọrịa nwere ike ime ka ize ndụ nsogbu ruo ọnwụ nke onye ọrịa. Ọzọkwa, ọrịa a na-ahụrụ na ndị inyom n'oge ime, emerụ ahụ ike nke nne na nwa.

N'ezie, ọtụtụ ndị mmadụ na-achọ ozi ndị ọzọ, ịjụ ajụjụ banyere ndị na-akpata ọrịa. Gịnị mgbaàmà ga m anya n'ihi na? Ọ bụ n'ebe a phospholipid syndrome analysis? Nwere ike na nkà mmụta ọgwụ na-enye ụzọ dị irè nke ọgwụgwọ?

Phospholipid syndrome: ihe ọ bụ?

N'ihi na oge mbụ na ọrịa a kọwara na nso nso. Official ọmụma banyere ya na-ebipụta na 1980s. Ebe ọ bụ na-arụ ọrụ na-amụ English rheumatologist Grem Hyuz, ọrịa a na-ezo dị ka Hughes syndrome. E nwekwara ndị ọzọ na aha - antiphospholipid syndrome, antiphospholipid antibody syndrome.

Phospholipid ọrịa - autoimmune ọria nke na dịghịzi usoro amalite amị-alụso ọrịa ọgụ nke ọgụ ahụ nwere phospholipids. Ebe ọ bụ na a umi esịne ke akpụkpọ ahụ nke ọtụtụ cell mgbidi, na lesion n'okpuru ndị dị otú ahụ dị ịrịba ama ọrịa:

• The-alụso ọrịa ọgụ na-awakpo ike endothelial mkpụrụ ndụ, na-ebelata ibu ihe na njikọ nke prostacyclin, nke bụ maka mmụba nke arịa mgbidi. Against ndabere nke ọrịa na e nwere a mebiri platelet aggregation.
• Phospholipids na-dị na mgbidi nke platelet onwe ha, nke na-eduga ụba aggregation na ngwa ngwa mbibi.
• Na ọnụnọ nke-alụso ọrịa ọgụ a hụrụ abawanye na ọbara clotting na-agwụ ike nke heparin ọrụ.
• The usoro mbibi na-adịghị emebiwo na akwara mkpụrụ ndụ.

Ọbara-amalite clot na ọbara arịa, akpụ egbochi mkpụkọ na-akpaghasị ọbara, na ya mere ndị ọrụ nke dị iche iche na akụkụ - ya mere na-emepe emepe a phospholipid syndrome. Akpata na mgbaàmà nke ọrịa nke na-adọrọ mmasị ọtụtụ ndị. Mgbe niile, na mee elu mee ọrịa na-ahụrụ, na obere nsogbu ga ịzụlite na ndidi.

The isi na-akpata ọrịa

Gịnị mere ndị mmadụ ịzụlite phospholipid syndrome? Ihe mere nwere ike dị iche iche. Ọ maara na nke ukwuu mgbe onye ọrịa nwere mkpụrụ ndụ ihe nketa pụrụ ịrịa. Ọrịa na-amalite ma ọ bụrụ na a malfunction nke dịghịzi usoro, nke na n'ihi ihe ụfọdụ na-amalite na-emepụta-alụso ọrịa ọgụ na-ahụ onwe mkpụrụ ndụ. Na nke ọ bụla, ọrịa ga-ihe triggered. Ka ụbọchị, ndị ọkà mmụta sayensị nwee ike ịchọpụta ọtụtụ ihe ize ndụ ihe:

• Phospholipid ọrịa mgbe amalite na ọnụnọ nke microangiopathy, karịsịa trobotsitopenii, hemolytic-uremic syndrome.
• Ihe ize ndụ ihe na-agụnye ndị ọzọ autoimmune ọrịa ndị dị ka lupus erythematosus, vasculitis, scleroderma.
• Ọrịa na-amalite na ọnụnọ nke cancer na ndidi.
• Ihe ize ndụ ihe na-agụnye na-efe efe. A ihe ize ndụ bụ na-efe efe mononucleosis na AIDS.
• -Alụso ọrịa ọgụ pụrụ iyi na DIC.
• Ọ maara na ọrịa nwere ike ịzụlite na ọrịa na-anata ụfọdụ ọgwụ, gụnyere mmiri ọgwụ gbochie afọ, psychotropics, "novokainamid" na t. D.

Kwesịrị ịdị, ọ dị mkpa iji chọpụta ihe mere ọrịa azụlitewo a phospholipid syndrome. Nchoputa na ọgwụgwọ a ga-amata na ọ bụrụ na o kwere omume kpochapụ ihe kpatara ọrịa ahụ.

The mmeri nke obi usoro mgbe phospholipid syndrome

Ọbara na ọbara arịa - a mbụ "lekwasịrị" na-emetụta phospholipid syndrome. Mgbaàmà nke ọ na-adabere na ogbo nke ọrịa. Egbochi mkpụkọ nke ọbara na-emekarị na-etolite ke akpa N'ịdị nke obere arịa. Ha agbaji ọbara iyi, nke na-esonyere anụ ahụ ischemia. Otụk N'ịdị bụ mgbe jụụ na aka, ikpa amama ọtọ na uru nke nta nke nta atrophy. Ruo ogologo oge n'erighị anụ ahụ na-eduga ná necrosis na ure anụ ahụ na-esokwa.

Chance na miri akwara thrombosis N'ịdị, nke na-esonyere ọzịza, ihe mgbu, mkpọchị agagharị. The phospholipid syndrome pụrụ ịdị mgbagwoju anya site thrombophlebitis (mbufụt nke vaskụla mgbidi), na na-esonyere fever, akpata oyi, anụ nācha ọbara-ọbara na lesion na-egbusi, edisọp mgbu.

guzobe egbochi mkpụkọ nke ọbara na isi ọbara arịa nwere ike na-eduga mmepe nke na-esonụ pathologies:

• aortic syndrome (esonyere a nkọ na-abawanye na mgbali arịa nke elu ahu);
• syndrome, nke ka vena cava (n'ihi na a nyere ọnọdụ ji edema, cyanosis nke anụ ahụ, na-agba ọbara si imi, oghere eji ekunye ume na nkọlọ);
• syndrome nke usụhọde vena cava (esonyere a nsogbu nke ọbara na-ala akụkụ nke ahụ ahụ, N'ịdị ọzịza, ihe mgbu na ụkwụ, ike, afo na ukwu).

Thrombosis emetụta ịrụ ọrụ nke obi. Ọtụtụ mgbe, ndị ọrịa na-esonyere mmepe nke rịaworo, persistent ọbara mgbali elu, myocardial infarction.

mmebi nke akụrụ na isi mgbaàmà

Thrombus guzobere na-eduga ná ogbenye mgbasa, ọ bụghị nanị na aka na ụkwụ - na-ata ahụhụ esịtidem akụkụ, karịsịa na akụrụ ya. Na ogologo oge mmepe nke phospholipid syndrome ọ bụ omume na-akpọ gbasara akụrụ infarction. Nke a ọnọdụ na-esonyere ihe mgbu na ala azụ, na-ebelata ego nke mmamịrị na ọnụnọ nke ọbara dị na ya nke adịghị.

The clot nwere ike igbochi ndị gbasara akụrụ akwara, nke na-esonyere nkọ mgbu, ọgbụgbọ na vomiting. Nke a bụ a dị ize ndụ ọnọdụ - ma ọ bụrụ na ekpe untreated, nwere ike ịzụlite necrotic usoro. Ize Ndụ pụta phospholipid syndrome gụnyere akụrụ microangiopathy na nke obere egbochi mkpụkọ nke ọbara na-guzobere ozugbo na gbasara akụrụ glomeruli. Ndị dị otú ahụ a ọnọdụ na-akpatakarị na mmepe nke-adịghị ala ala gbasara akụrụ odida.

Mgbe ụfọdụ, e nwere ogbenye mgbasa ke adrenal glands, nke na-eduga ná emeghasịkwa nke mmiri ọgwụ na-etoju.

Gịnị ọzọ na akụkụ nwere ike na-emetụta?

Phospholipid syndrome - a ọrịa na-emetụta ọtụtụ akụkụ. Dị ka e kwuru, na-alụso ọrịa ọgụ na-emetụta neuronal cell membranes, nke nwere ike ime na-enweghị nsogbu. Ọtụtụ ndị ọrịa mkpesa nke mgbe nile na-ike isi ọwụwa na-esokarị site na dizziness, ọgbụgbọ na vomiting. E nwere a-ekwe omume nke mmepe nke dị iche iche na ọrịa uche.

Ụfọdụ ọrịa egbochi mkpụkọ na ọbara arịa na-enye ọbara na optic analyzer. Ruo ogologo oge enweghị oxygen na nri na-eduga ná atrophy nke optic akwara. Ekwe Omume thrombosis nke retinal arịa na ụdi hemorrhage. Ụfọdụ n'ime ocular pathologies, dị mwute ikwu, irreversible: visual impairment ịnọgide na-enwe ndidi n'ihi na ndụ.

Na-enweghị nchịkwa na usoro nwere ike aka na ọkpụkpụ. Ndị mmadụ na-chọpụtara reversible osteoporosis, nke na-esonyere deformation nke ọkpụkpụ na Ugboro fractures. Ihe ize ndụ bụ aseptic necrosis nke ọkpụkpụ.

N'ihi na ọrịa na e ji anụ ọnya. Ọtụtụ mgbe, ndị akpụkpọ nke elu na nke ala na nsọtụ na-guzobere ududo veins. Mgbe ụfọdụ, ị ga-achọpụta na a nnọọ ihe e ji mara ihe ọkụ ọkụ, nke yiri a obere, pinpoint hemorrhages. Ụfọdụ ọrịa ịzụlite erythema na ọbụ ụkwụ na ọbụ aka ya. E nwere a ugboro ugboro subcutaneous hematoma guzobere (dịghị o kpatara) na-agba ọbara n'okpuru ntu efere. Ruo ogologo oge nsogbu nke trophic anụ ahụ gụnyere ọnyá na ogologo-agwọ ma na-esi ike na-emeso.

Anyị chọpụtara na bụ a phospholipid syndrome. Akpata na mgbaàmà nke ọrịa - pụrụ iche okwu. Mgbe ihe a nile na ga-adabere na họọrọ dibịa ọgwụgwọ Usoro.

Phospholipid syndrome: nchoputa

N'ezie, nke a dị oké mkpa oge iji chọpụta ọnụnọ nke ọrịa. Na-enyo enyo phospholipid syndrome, dọkịta gị nwere ike ọbụna n'oge anamnesis. Push na a echiche ma ọ bụrụ na onye ọrịa bụ ike nke na thrombosis na venous ọnyá, Ugboro ime ọpụpụ, ihe ịrịba ama nke anaemia. N'ezie, ihe ọzọ ọzọ ule.

Analysis nke phospholipid syndrome mejupụtara na-ekpebi na ọkwa nke-alụso ọrịa ọgụ na phospholipids n'ime ọbara nke ọrịa. Ke ofụri ofụri, analysis of ọbara nwere ike na-achọpụta a gụnyere ya ná platelet ọnụ, mụbara erythrocyte sedimentation ọnụego, ọnụ ọgụgụ ka elu nke leukocytes. Ọtụtụ mgbe, ndị syndrome na-esonyere hemolytic anaemia, nke nwekwara ike ike hụrụ na laabu ọmụmụ.

Ọzọkwa rụrụ ọbara onwu. Onye ọrịa nwere ibu gamma globulins. Ọ bụrụ na ndabere daa ọrịa e mebiri imeju, enwekwu ego nke bilirubin na ọbara, na alkaline phosphatase. Na ọnụnọ nke gbasara akụrụ ọrịa pụrụ hụrụ abawanye na ọbara creatinine na urea.

Ụfọdụ ọrịa na ike ikwu na kpọmkwem immunological ọbara ule. Ka ihe atụ, laabu ọmụmụ nwere ike na-akpa àgwà na-ekpebi ọrịa ogbu-akpata na-lupus coagulant. Mgbe phospholipid syndrome ọbara nwere ike ịchọpụta ọnụnọ nke-alụso ọrịa ọgụ na mkpụrụ ndụ ọbara uhie, mụbara lymphocytes. Ọ bụrụ na e enyo nke oké njọ mmebi nke imeju, akụrụ, ọkpụkpụ, e nwere ga-abụ instrumental ule, gụnyere X-ray, ultrasound Onyonyo.

Gịnị na-na nsogbu nke ọrịa a na-ejikọta?

Ọ bụrụ na untreated, na phospholipid syndrome pụrụ iduga nnọọ ize ndụ nsogbu. Against ndabere nke ọrịa na ọbara arịa kpụrụ-egbochi mkpụkọ, nke ya onwe ya bụ ize ndụ. Egbochi mkpụkọ nke ọbara-egbochi ọbara arịa, na-akpaghasị nkịtị ọbara mgbasa - anụ ahụ na akụkụ na-adịghị enweta ezuru nri na oxygen.

Ọtụtụ mgbe megide ndabere nke ọrịa, ọrịa ịzụlite ọrịa strok, na myocardial infarction. N'ịdị embolism pụrụ iduga ure anụ ahụ. Dị ka e kwuru n'elu, ọrịa na-hụrụ malfunction nke akụrụ na adrenal glands. The kasị dị ize ndụ n'ihi a akpa ume embolism - a daa ọrịa amalite acutely, na bụghị mgbe nile, a ndidi ada ada na-anapụta na oge ụlọ ọgwụ.

Pregnancy na ọrịa na phospholipid syndrome

Dị ka ekwuola, na phospholipid syndrome na-chọpụtara n'oge ime. Olee otú ize ndụ ọrịa na ihe na-eme n'ọnọdụ dị otú ahụ?

N'ihi phospholipid syndrome na arịa kpụrụ egbochi mkpụkọ na clog akwara ebu ọbara Plasenta. Nwa adịghị anata ezu oxygen na nri, na 95% nke ikpe a na-eduga ná ime ọpụpụ. Ọbụna ma ọ bụrụ na ime na-adịghị etre, e nwere ihe ize ndụ nke placental abruption n'oge na mbubreyo mmepe nke preeclampsia, nke dị nnọọ ize ndụ n'ihi na ma nne na nwa.

N'eziokwu, a nwaanyị a ga-anwale na atụmatụ ogbo. Otú o sina phospholipid syndrome na-chọpụtara n'oge ime. N'ọnọdụ dị otú ahụ, ọ dị ezigbo mkpa na-achọpụta na ọnụnọ nke ọrịa na na-na ọ dị mkpa jikoro. N'ihi mgbochi nke ga-eme n'ọdịnihu nne thrombosis nwere ike kenyere anticoagulation na obere doses. Ke adianade do, ndị inyom a ga-ahụ mgbe nile na ekwu nke na dọkịta nwere ike na-amalite na-achọpụta placental abruption. Ọ bụla ọnwa ole na ole, abụ nne na-emeso ya na-ewusi ike ọgwụ, na-ewere preparations nwere vitamin, minerals na antioxidants. Na na nri obibia, afọ ime mgbe agwụ n'enweghị nsogbu.

Gịnị bụ ọgwụgwọ?

Gịnị ma ọ bụrụ na a onye na-hụrụ phospholipid syndrome? Ọgwụgwọ na nke a mgbagwoju, na ọ na-adabere ọnụnọ ke a ndidi ụfọdụ nsogbu. Dị ka ndabere nke ọrịa n'ụdị egbochi mkpụkọ, na ọgwụ na-isi iji na-thinning ọbara. The ọgwụgwọ Usoro-emekarị na-agụnye iji ọtụtụ dị iche iche nke ọgwụ ọjọọ eme ihe:

• First họpụtara anticoagulants nke anọ edinam, antiplatelet elekọta mmadụ ( "aspirin", "Warfarin").
• Agwọ na-agụnyekarị nhọrọ ndị na-abụghị steroidal mgbochi mkpali ọgwụ ọjọọ nke si na ya, karịsịa "Nimesulide" ma ọ bụ "Celecoxib".
• Ọ bụrụ na ọrịa na-ejikọta ya na systemic lupus erythematosus na ụfọdụ ndị ọzọ autoimmune ọrịa, dọkịta nwere ike nye iwu ka steroid omume (mmiri ọgwụ mgbochi mkpali ọgwụ ọjọọ). Yana a mee ihe, immunosuppressive ọgwụ ndị na-ebelata ọrụ nke dịghịzi usoro ma mbenata mmepụta nke ize ndụ-alụso ọrịa ọgụ.
• Ụmụ nwaanyị dị ime na mgbe ụfọdụ intravenously ndinọ immunoglobulin.
• Ọrịa na-oge na-ewere preparations nwere vitamin nke otu B.
• N'ihi na izugbe ahụ ike, na-echebe cellular membranes na arịa na-eji ọgwụ ọjọọ eme ihe, antioxidants, na-preparations nke nwere a mgbagwoju nke polyunsaturated ọdụdụ asịd ( "Omacor", "Mexicor").

Aka na ọrịa na-arịa na-emetụta electrophoresis usoro. Mgbe ọ na-abịa nke abụọ phospholipid syndrome, ọ dị mkpa ịchịkwa bụ isi ọrịa. Ka ihe atụ, ọrịa na vasculitis na lupus ga-enweta ezigbo ọgwụgwọ ndị a pathologies. Ọ dịkwa mkpa oge iji chọpụta ọrịa na-ebu ndị kwesịrị ekwesị ọgwụ ruo mgbe zuru ezu na mgbake (ma ọ bụrụ na o kwere omume).

The prognosis maka ọrịa

Ọ bụrụ na phospholipid syndrome a chọpụtara na oge na-enwe ndidi natara ndị dị mkpa na-elekọta, na-prognosis bụ nnọọ mma. Iji tufuo ọrịa bụ mwute ikwu na o kwere omume, ma na ọgwụ nwere ike ịchịkwa ya nkpasu-iwe na preventative ọgwụgwọ nke thrombosis. Weere nsogbu nke ọrịa na-ejikọta ya na thrombocytopenia na ọbara mgbali elu.

Na nke ọ bụla, n'okpuru nlekọta nke a rheumatologist kwesịrị niile ọrịa na a nchoputa nke "phospholipid syndrome." Site ugboro ugboro analysis dị ka otú mgbe ị chọrọ ịgafe ule na ndị ọzọ dọkịta ihe ọgwụ kwesịrị iwere dị ka nyochaa ala nke ahụ ahụ nke ya - niile a ga-agwa ndị na ịga dibịa.