Immunoglobulin E na ya n'ahụ uru

Immunoglobulin E na ya n'ahụ mkpa - mbipụta nke na-achọ ihe echiche. Ugbu a, e nwere ọtụtụ ụdị nke immunoglobulins (-alụso ọrịa ọgụ). E nwere ọtụtụ ụdị nke-alụso ọrịa ọgụ na dị iche na odidi nke edinam na usoro nke mgbochi infective ọgụ. -Alụso ọrịa ọgụ akpasu ọdịda na flocculation nke etisasịwo nje na ngwaahịa, agglomeration na agglutination corpuscular abụkwara (spirochetes, nje, mmadụ nje na bacteria). Mgbe cell akpụkpọ ahụ vibrios trypanosomes na ofu spirochetes immunoglobulins kpọmkwem okụre na zuo ezu, na-eme platelet adsorption. A, ndị a na-efe efe mmadụ na-edebe na lymphoid anụ ahụ. The immunoglobulins nke ọmụmụ G na M na ezu ike hydrolyze spirochetes, trypanosomes, bacteria na nje virus.

Mmetụta nke-alụso ọrịa ọgụ na nje na-kwụsịtụrụ mgbe ọ na-abatakwa cell, na bụghị na-egosi antigen na cell n'elu. Immunoglobulins nwere ike ma ọ bụ ghara ịdị na-alụso ọrịa ọgụ na-eguzogide nke organism. Antigen-antibody mgbagwoju nke nwere antigen ngafe, anamde a na-akpali akpali mmetụta, na mgbagwoju na ngafe nke-alụso ọrịa ọgụ na-akpata na-abụghị mmetụta. Ọtụtụ mgbe, ndị immunoglobulins bụ kpatara autoimmune na anabata nsogbu.

IgE na-synthesized tumadi na mkpụrụ ndụ nke mucous membranes nke akụkụ okuku ume, gastro-nsia tract, nakwa dị ka na mpaghara Lymph. N'ihi na oge mbụ, dị ka a iche iche klas nke immunoglobulin E matara na 1966, na 1968, ndị WHO ka ghọtara dị ka onwe ha IgE klas nke immunoglobulins.

a na klas nke na-edozi hụrụ na ụmụ mmadụ, primates na ụfọdụ laabu ụmụ anụmanụ. Ọtụtụ n'ime ndị E immunoglobulin ụmụ irighiri jikọrọ akpụkpọ poolu sel basophils. Ebe ọ bụ na n'okpuru nkịtị ọnọdụ immunoglobulin E kasịnụ n'ime ọbara ọbara nke a ole na ole nanograms kwa milliliter, na echiche bụ isi nke ihe owuwu nke a molekul a nwetara naanị na ndabere nke na-amụ ọtụtụ myeloid edozi. Nnọọ ala etoju nke immunoglobulin E na ọbara doro anya na-ebilite si eziokwu na ọ bụ ike nke na "dọtara" na elu nke mkpụrụ ndụ na ike eke agbụ na osisi ọkọlọtọ sel basophils.

Ọ na-kweere na Іg E bụ isi na klas nke immunoglobulins nke na-emepụta poolu sel basophils isonye na nfụkasị Jeremaya. Larịị nke a protein na ọbara nke ọrịa na anataghi na-abawanye na-emekarị karịa 350-800 U / mg. Total IgE ya norm na ụmụaka na-erubeghị afọ 12 ọnwa ruo 15 U / ml. IgE ekere òkè dị mkpa na Jeremaya mere, nke ozugbo hypersensitivity. Immunoglobulin E norm okenye mbio 0 120 U / ml.

Dị ka oge a echiche, isi ọrụ nke immunoglobulin E bụ iji chebe ahụ mucous membranes ruru ka ebighị nke obodo ihe ọbara plasma na effector mkpụrụ ndụ. Nje na-enwe ike imebi site nchedo akara na mejupụtara immunoglobulins nke klas A. Mgbe na nje ma ọ bụ nje bacteria na-elu nke poolu mkpụrụ ndụ kee kpọmkwem immunoglobulin E klas, dị ka a n'ihi nke ndị dị otú ahụ na mmekọrịta poolu mkpụrụ ndụ na-enweta a mgbaàmà nyak nke vasoactive amines na chemotactic ihe, nke n'aka nke na-akpata inflow nke ekesa IG klas ndị G, zuo ezu, eosinophils na neutrophils. Eosinophilic chemotactic akpata, nke a na-ẹkesiode poolu mkpụrụ ndụ, na-akwalite ìgwè eosinophils na mbibi nke ikpuru. Ọ na-kweere na IgE adsorbed n'elu nke nje, na-adọta macrophages ekele FC-anabata.