Ọgwụ "valparin": ntuziaka maka ojiji, mejupụtara, synonyms, kachasị yitebe. Nyocha nkwadebe

Gịnị mere m mkpa ọgwụ "valparin"? Ntuziaka maka ojiji, synonyms na-egosi nke a ọgwụ na-kọwara n'isiokwu a.

Na udi ma na mejupụtara nke

Olee ụdị bụ pụta ụwa ọgwụ "valparin"? Tablet - ọ na-na ụdị ọgwụ na ajụjụ ike zụrụ na ahịa ọgwụ. Ha na-egosipụta a ruo ogologo oge eme ihe, a gburugburu biconvex udi, na a na-acha ọcha na agba mkpuchi.

Na akụkụ nke ọgwụ "valparin"? Guide na-enye na ngwá ọrụ nwere valproic acid na sodium valproate. Ọ na-agụnye ndị na-esonụ excipients: glycerol, colloidal sịlịkọn dioxide, evdragit E-100, hydroxypropylmethylcellulose, polyethylene glycol 1500, ethylcellulose, sodium saccharin, sịlịkọn dioxide hydrate, evdragit BỤGHỊ-30D, titanium dioxide na talc.

Zụrụ mbadamba nwere ike anya na ibe 10 mbak na a katọn ùkwù karị.

The ọgwụ

Olee otú ọgwụ "valparin"? Ntuziaka maka ojiji (mejupụtara pụtara kọwawo n'elu) na-ekwu na ọ bụ ihe anticonvulsant ọgwụ. O nwere a sodium valproate ọdịnaya nke ime Geba na ụbụrụ, nke na-eme ka ya na-abawanye na postsynaptic akwara ozi.

Anyị ga na-ekwukwa na akụrụngwa na ajụjụ ekpebi iga nke potassium ion gafee neuronal membranes. Nke a usoro suppresses mmepe na mgbasa nke akwụkwụ excitation na akwara ozi.

Ọ kwesịkwara kwuru na sodium valproate nwere anticonvulsant mmetụta dị iche iche na iche nke Akwụkwụ na-adọ.

Drug "valparin" adịghị enweta ogwuura na hypnotic mmetụta, na-adịghị mwute etiti nke ume. Ke adianade do, ya n'ọrụ mgwa nwere dịghị oghom mmetụta na obi ọnụego, ahu okpomọkụ nke ọrịa, ya ọbara mgbali na akụrụ ọrụ.

The kinetic Njirimara nke ọgwụ

Gịnị bụ pharmacokinetic e ji mara nke ọgwụ nwere "valparin"? Guide na-azọrọ na mgbe na-ewere ọgwụ n'ime a na-achịkwa ntọhapụ nke nọ n'ọrụ umi-amalite ozugbo, mgbe 2-8 awa, esịmde a kacha plasma larịị.

Bioavailability n'aka atụle 100%.

The ọgwụgwọ mmetụta nke ọgwụ na-egosi na mgbe na-eru valproic acid ịta na ọbara, hà 45-100 mg / l. Ọ ga-ekele na ọgwụgwọ na pharmacological omume nke n'aka achịkwa ntọhapụ isi akụrụngwa ọ bụghị mgbe nile na-adabere na plasma kasịnụ.

Communication atụle ọgwụ na plasma-edozi bụ mkpokọta 85-90%. Ọ na-metabolized na umeji bụ mmepụta ọnụ na mmamịrị. Na nke mbụ a-ngafe metabolism a hụrụ.

Ọkara ndụ-nke ahụ gị n'ụlọnga bụ banyere 9-20 awa. Na ụmụ, na oge a na-ebelata.

Egosi maka mbanye

N'okpuru ihe ọnọdụ ndị kasị dị irè iji ọgwụ na-akpa àgwà "valparin"? Ntuziaka maka ojiji, n'ezie na ahụmahụ ọkachamara akụkọ na kwuru agwọ ọrịa na-emepụta kpọmkwem maka ọgwụgwọ nke generalized Akwụkwụ na-adọ, gụnyere ndị na-esonụ iche nke ọgụ:

• myoclonic;
• abịaghị;
• atonic;
• tonic-clonic.

Ọzọkwa, a ọgwụ na-kenyere ele mmadụ anya n'ihu Akwụkwụ na-adọ, na ndị ọzọ kpọmkwem, na:

• sekọndrị generalized ọdịdọ;
• jikọtara ma ọ bụ dị mfe ọdịdọ.

Ke adianade do, mbadamba na-ewerekarị eji mgbe a kpọmkwem ọrịamkpokọta (Lennox-Gastaut syndrome, West).

Bans ojiji nke mbadamba

Ọ nwere ihe ọ bụla contraindications ọgwụ "valparin"? Dị ka ntụziaka site na ngwá ọrụ, e nwere ọtụtụ mgbochi iji ihe:

• n'oge ime;
• oké ọrịa na pancreas;
• thrombocytopenia;
• ịba ọcha n'anya nnukwu ma ọ bụ ala ala;
• porphyria;
• ifịk ịba ọcha n'anya ikpe (ọgwụ Jenesis);
• ara;
• afọ nke ụmụaka afọ atọ;
• hypersensitivity ọgwụ, gụnyere valproic acid.

Anticonvulsant "valparin": ntuziaka maka ojiji

The onunu ogwu nke ọgwụ a họọrọ n'otu n'otu, na-adabere arọ ahụ na afọ nke onye ọrịa.

A, maka okenye amalite dose bụ 600 mg nke ọgwụ kwa ụbọchị. Na ndị na-esonụ nọmba a mụbara site na 200 mg (ọ bụla ụbọchị atọ nweta chọrọ N'ihi).

Multiplicity ndibọbọ pụtara n'okpuru echiche bụ 1-2 ugboro kwa ụbọchị. The kacha na-atụ aro usoro onunu ogwu bụ 1-2 g nke ọgwụ kwa ụbọchị.

Mbadamba "valparin", ntuziaka maka ojiji nke na-atụle a akwụkwọ ga-elo dị ka a dum, na-aṅụ a obere ego nke mmiri ọkụ.

Na ndị agadi ndị na-dosing Usoro nke ngwá ọrụ a yiri ihe dosing Usoro na okenye ọrịa, ma họrọ na n'otu n'otu.

Maka ụmụ ọhụrụ erikpu 20 n'arọ mbụ dose of agwọ ọrịa bụ 400mg kwa ụbọchị. Ọ dị mkpa ka dịkwuo ego iji nwayọọ nwayọọ nweta chọrọ N'ihi (banyere 20-30 mg / n'arọ kwa ụbọchị, na 1-2 doses).

Child erikpu elu 20 n'arọ ekenye anticonvulsant ọgwụ ajuru aju.

Omume by-agwa

Gịnị bụ mmetụta na-akpata "valparin" mbadamba? Ntuziaka maka ojiji notifies na oriri nke a ọgwụ mmadụ ọrịa nwere ike na-enwe ekwesighi mmetụta:

• Nfụkasị Jeremaya: Stevens-Johnson syndrome, anụ ọkụ ọkụ, erythema multiforme, pruritus, anụ ahụ, photosensitivity.
• Digestive usoro: ọgbụgbọ, ịba ọcha n'anya, vomiting, afọ ntachi, afọ ọsịsa, pancreatitis.
• Omumu usoro: amenorrhea sekọndrị, oge ufodu nanso.
• CNS: Coma, mara jijiji, ataxia, mkpọchị nsụhọ.
• hemopoietic usoro: anaemia, platelet aggregation mgbochi, thrombocytopenia, leukopenia, neutropenia, ebelata fibrinogen.
• Ndị ọzọ: ibu ibu, ntutu isi ọnwụ, ọbara creatinine, hyperammonemia.

ovadozu anticonvulsant

Gịnị mgbaàmà nwere ike ime mgbe na-ewere elu doses nke ọgwụ "valparin"? Ntuziaka maka ojiji (mbadamba ike zụrụ na bụla ahịa ọgwụ na ndenye ọgwụ) rụrụ ụka na ka ụbọchị nke kpachaara anya ma ọ bụ na mberede ovadozu nke ọgwụ n'okpuru echiche kọrọ adịkarịghị. Dị ka a na-achị, ndị mebiri nke dosing nke ọgwụ na-eme ka ọdịdị nke ọgbụgbọ, dizziness, vomiting, afọ ọsịsa, akụkụ okuku ume na ịda mbà n'obi, Coma, na hyporeflexia.

Iji kpochapụ ọnọdụ ndị dị otú ọrịa na-kenyere gastric lavage na-arụ ọrụ unyi. Ọ bụrụ na ọ dị mkpa, na-enwe ndidi ọgwụgwọ a rụrụ n'ụdị symptomatic ọgwụ na hemodialysis.

Mmekọrịta ndị ọzọ ọgwụ ọjọọ eme ihe

Ma-abanye mmekọrịta na ndị ọzọ ọgwụ ọjọọ eme ihe na nkà mmụta ọgwụ "valparin"? Ntuziaka maka ojiji na-agwa onye ọrịa na sodium valproate ka ikowa mmetụta nke antipsychotics, antidepressants na antiepileptic ọgwụ ọjọọ.

N'adịghị ka ndị ọzọ anticonvulsants , atụle bụghị ọgwụ akwalite hepatic enzyme itinye n'ọkwa, ya mere ọ na-adịghị belata irè nke ọnụ na gbochie afọ.

Ke ukem n'ikuku nke "warfarin" na sodium valproate ebelata pasent nke nkịtị na plasma-edozi mbụ.

N'ọrụ ọgwụ umi a na-ewere ike ịgbanwe plasma kasịnụ nke lamotrigine, na phenytoin. Mgbe ọ na-achọkwa na-na nkwekọrịta nke acetylsalicylic acid anticoagulant na antiplatelet mmetụta enwekwukwa.

Na n'otu oge eji "valparin" si ethanol na ndị ọzọ ọgwụ ọjọọ eme ihe ndị ga-akụda CNS emechi (e.g., Mao inhibitors bụ tricyclic antidepressants, antipsychotic ọgwụ ọjọọ) nwere ike enwekwukwa CNS ịda mbà n'obi.

Mmanya na ndị ọzọ hepatotoxic ọgwụ ọjọọ na-amụba ihe ize ndụ nke imeju mebiri.

E lee ya anya Nwa enwekwu ọkara ndụ "lamotrigine" na slows ala ya metabolism na suppresses hepatic enzymes. Na njikọ na a ọkara ndụ nke ọgwụ nwere ike ụba ruo awa 70 na okenye ọrịa na ruo 45 awa - ụmụaka.

"Valparin" bụ ike belata nwechapụ "zidovudine" site banyere 40%. Ọzọkwa, ya ọkara ndụ adịghị agbanwe.

Mao inhibitors antidepressants, tricyclic na antipsychotic ọgwụ (neuroleptics), nakwa dị ka ndị ọzọ ọgwụ ọjọọ eme ihe na ala ọdịdọ fọrọ, nke ukwu belata irè nke na-atụle agwọ ọrịa.

Ara na ime

Dị ka ndị ọkachamara, na ojiji nke ọgwụ ọjọọ, "valparin" n'oge gestation bụ nanị kwe omume ma ọ bụrụ na ndị chọrọ uru n'ọdịnihu nne budata karịa ndị nwere ihe ize ndụ ka nwa.

Mgbe anata ọgwụ n'oge ime, jide n'aka na-eduzi a pụrụ iche prenatal nlekota nke nwa ebu n'afọ.

Iji ọgwụ n'oge lactation adịghị atụ aro.

Specific ọmụma

Tupu ị malite ọgwụgwọ nke ego, ijide n'aka na-ịkpọ dọkịta gị.

Na usoro nke na-anata anticonvulsant ọgwụ na-achọ mgbe nile nlekota nke bilirubin na ọbara, amylases na platelet, nakwa dị ka imeju transaminases (ọ bụla ọnwa 3).

Dị ka ndị ọkachamara, valproic acid bụ ike nke na inhibiting platelet aggregation. Nke a na-eme nnọọ ihe ize ndụ nke ụba ọbara coagulation oge na-agba ọbara. Ọ dị mkpa n'ime akaụntụ likelihood nke nsogbu na na-metụtara ọbara ọgbụgba na postoperative oge, na ndị mmadụ na-anata sodium valproate.

Ọ bụrụ na ogologo oge ọgwụgwọ a ọgwụ na ọrịa nwere ike ịzụlite n'amaghi ọbara ọgbụgba na hematoma kpụrụ. Na nke a, ọgwụ ga-akwụsị ozugbo.

Dị ka e kwuru n'elu, sodium valproate, a ọgwụ na-akpatakarị pancreatitis, na-akwalite-emeghasịkwa nke imeju ọrụ (na-emekarị ke akpa 6 ọnwa nke ọgwụgwọ). Na nke a, na mmalite nke usoro ọgwụgwọ dị mkpa inyocha na ịchọpụtakwa ọnọdụ nke pancreatic cancer ọrịa, nakwa dị ka mgbe nile nyochaa imeju ọrụ ule, na larịị nke prothrombin.

Ọrịa nke na imeju na-hepatic ọdịda ọrịa na-anata sodium valproate pụrụ hụrụ na ụmụ Akwụkwụ na-adọ na metabolic na degenerative ọrịa,-eme iberibe na organic ụbụrụ anụ ahụ daa ọrịa.

Na chọpụtara nke ndị dị otú ahụ ihe ịrịba ama dị ka lethargy, akara adịghị ike, ọzịza, na vomiting, jaundice, kwesịrị ozugbo kwụsị ojiji nke agwọ ọrịa.

Na ọgwụgwọ nke "valparin" onye ọrịa ga-abụ nnọọ anya mgbe na-arụ ọrụ dị ize ndụ ígwè. Nke a bụ n'ihi na eziokwu na-arụsi ọrụ ike agwọ ọrịa bụ ike nke na mbenata ịta.

Usoro na ọnọdụ nke nchekwa

Anticonvulsant mkpụrụ ọgwụ "valparin" akụzi na pharmacies na na ndenye ọgwụ nke dọkịta. Ha ga-echekwara na-apụghị iru nke ụmụaka na-echebe site na mmiri ma na okpomọkụ nke bụghị ihe karịrị 30 degrees.

Adị ndụ nke ọgwụ n'okpuru echiche bụ afọ atọ (site na ụbọchị nke rụpụta).

Agwọ ọrịa "valparin": analogues, synonyms

The ọgwụ na ajụjụ nwere ike dochie anya ya? Synonyms na analogues na ngwá ọrụ a, na e nwere ọtụtụ. Ndị a gụnyere ndị na-esonụ ọgwụ: "Apilepsin" "Depakine," "Atsediprol" "Depakine Enterik" "Depakine Chronosphere" "Depakine Chrono", "Dipromal", "Konvulsofin", "Konvuleks", "Orphir" "Enkorat", "Everiden", "Enkorat Chrono".

Dị ka ọ dị na "valparin", ndị a ego kwesịrị iwere na na dọkịta iwu, na-atụ aro Dosages nditịm.

Echiche nke na-eji ọkụ na ndị ọkachamara

Gịnị dọkịta na-ekwu banyere nke a ọgwụ, ndị dị ka "valparin"? Ọbịa ọkachamara na-egosi na ọgwụ dị irè na oru oma, karịsịa na generalized na ele mmadụ anya n'ihu Akwụkwụ na-adọ.

Ma na ọkụ eletrik, ọtụtụ n'ime ha kweere na uche nke onye dibịa. Ọrịa na-ekwu na nke a ndibọbọ pụtara mmemmem ngwa mmepe na-agbasa n'igbochi excitation (akwụkwụ) site akwara ozi. Otú ọ dị, ọ ga-ahụ kwuru na nke a ọgwụ bụ mgbe na-akpata mmetụta. Dị ka nzaghachi ndị ahịa, ndị akacha aa oghom Jeremaya mere bụ: akpụkpọ anataghi, ọgbụgbọ, anaemia, na ibu ibu. Ọ bụrụ na ị na-enwe ndị a mgbaàmà kwesịrị ozugbo kpọtụrụ a dọkịta.